About   Help   FAQ
Pds5b
Gene Detail
 Symbol
Name
ID
Pds5b
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
MGI:2140945
Synonyms Aprin, AS3, mKIAA0979
Feature Type protein coding gene
Genetic Map
Chromosome 5
89.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:150673739-150810690 bp, + strand
From VEGA annotation of GRCm38

  136952 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pds5b

Human
homologs
Human Homolog PDS5B, PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
NCBI Gene ID 23047
neXtProt AC  NX_Q9NTI5
Human Synonyms  APRIN, AS3, CG008
Human Chr (Location)  13q12.3; chr13:32586427-32778020 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(45) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic and neonatal lethality with cardiac defects, craniofacial abnormalities, axial skeletal defects, shortening of most of the long bones, abnormal enteric nervous system morphology, and decreased germ cells.
 
Phenotype Images(2)
Interactions
Pds5b interacts with 451 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell cycle, cell division, ...
Component chromatin, nucleus
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (196)    Tissues (102)    Images (13)
Theiler Stages: 2, 3, 4, 5, 22, 28
Assay TypeResults
RNA in situ 188
RT-PCR 8
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(16) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000017116 (Evidence)
Ensembl Gene ModelENSMUSG00000034021 (Evidence)
Entrez Gene100710 (Evidence)
DFCITC1575570, TC1589303, TC1597379, TC1597542, TC1657240
DoTSDT.101180045, DT.101402324, DT.110688349, DT.110688355, DT.94248371
NIA Mouse Gene IndexU006494
Consensus CDS ProjectCCDS39412.1
International Mouse Knockout Project StatusPds5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017116 VEGA Gene Model | MGI Sequence Detail 136952 C57BL/6J ±  kb
transcript OTTMUST00000041450 VEGA | MGI Sequence Detail 7417 Not Applicable 
polypeptide OTTMUSP00000018603 VEGA | MGI Sequence Detail 1446 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(498 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR017956 AT hook, DNA-binding motif
Protein Ontology PR:000012520 sister chromatid cohesion protein PDS5 homolog B
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:205601 Carretero M, et al., Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J. 2013 Nov 13;32(22):2938-49
All references(45)
Other
accession IDs
MGI:2141177

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory