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Pds5b Gene Detail
Summary
  • Symbol
    Pds5b
  • Name
    PDS5 cohesin associated factor B
  • Synonyms
    Aprin, AS3, Her-2 Tg, mKIAA0979, Tg(Wap-ERBB2)229Wzw, WAP-Her-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140945
    NCBI Gene: 100710
  • Gene Overview
    MyGene.info: PDS5B
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:150673744-150810669 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 89.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    495 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140945
protein coding gene Chr5:150673739-150810690 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030413
protein coding gene Chr5:156620749-156766959 (+)
A/J MGP_AJ_G0030386
protein coding gene Chr5:149908357-150059043 (+)
AKR/J MGP_AKRJ_G0030313
protein coding gene Chr5:154540398-154683856 (+)
BALB/cJ MGP_BALBcJ_G0030395
protein coding gene Chr5:151172079-151310308 (+)
C3H/HeJ MGP_C3HHeJ_G0030109
protein coding gene Chr5:155538191-155684184 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030850
protein coding gene Chr5:162330710-162481761 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028063
protein coding gene Chr5:144234452-144369565 (+)
CAST/EiJ MGP_CASTEiJ_G0029511
protein coding gene Chr5:155203015-155349058 (+)
CBA/J MGP_CBAJ_G0030087
protein coding gene Chr5:169173572-169333548 (+)
DBA/2J MGP_DBA2J_G0030231
protein coding gene Chr5:149559326-149695073 (+)
FVB/NJ MGP_FVBNJ_G0030185
protein coding gene Chr5:148804274-148941568 (+)
LP/J MGP_LPJ_G0030318
protein coding gene Chr5:157278752-157419399 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030221
protein coding gene Chr5:171232285-171380360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030880
protein coding gene Chr5:154497374-154641254 (+)
PWK/PhJ MGP_PWKPhJ_G0029225
protein coding gene Chr5:148728626-148867711 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029061
protein coding gene Chr5:151779600-151929212 (+)
WSB/EiJ MGP_WSBEiJ_G0029588
protein coding gene Chr5:155306723-155444563 (+)



Homology
more
  • Human Ortholog
    PDS5B, PDS5 cohesin associated factor B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDS5B, PDS5 cohesin associated factor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APRIN, AS3, CG008
  • Links
    NCBI Gene ID: 23047
    neXtProt AC: NX_Q9NTI5
    UniProt: Q9NTI5

  • Chr Location
    13q13.1; chr13:32586427-32778020 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41001
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PDS5B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic and neonatal lethality with cardiac defects, craniofacial abnormalities, axial skeletal defects, shortening of most of the long bones, abnormal enteric nervous system morphology, and decreased germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100710 NCBI Gene Model | MGI Sequence Detail 136926 C57BL/6J ±  kb
    transcript NM_001346503 RefSeq | MGI Sequence Detail 7314 C57BL/6  
    polypeptide Q4VA53 UniProt | EBI | MGI Sequence Detail 1446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR016024 Armadillo-type fold
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 17
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141177, MGI:3850476
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:235629 Bondurand N, et al., Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players. Dev Biol. 2016 Sep 15;417(2):139-57

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory