Mbd5
Gene Detail

Symbol Name ID

Mbd5 methyl-CpG binding domain protein 5 MGI:2138934

Synonyms

9430004D19Rik, C030040A15Rik, OTTMUSG00000012483

Feature Type

protein coding gene

Genetic Map

Chromosome 2

28.43 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:48949510-49322284 bp, + strand From VEGA annotation of GRCm38   372775 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Mbd5

Alleles and phenotypes

All alleles(18) : Targeted(5) Gene trapped(13)
 

Mice homozgyous for a knock-out allele exhibit severe postnatal growth retardation leading to lethality by P22, decreased body, brain and liver weights, reduced IGF-I and GH levels, and abnormal glucose homeostasis.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	glucose homeostasis, positive regulation of growth hormone receptor signaling pathway, ...
Component	chromosome, nucleus
Function	DNA binding

External Resources: FuncBase

Expression

cDNA source data(47)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(1) cDNA(47)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000012482 (Evidence)
Ensembl Gene Model	ENSMUSG00000036792 (Evidence)
Entrez Gene	109241 (Evidence)
UniGene	440436
DFCI	TC1593289, TC1601795, TC1602333, TC1734682
DoTS	DT.101374051, DT.486251, DT.55183499, DT.55215665, DT.91327156, DT.94124120
NIA Mouse Gene Index	U001741, U042290
Consensus CDS Project	CCDS38122.1
International Mouse Knockout Project Status	Mbd5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012482	VEGA Gene Model | MGI Sequence Detail	372775	C57BL/6J
transcript	OTTMUST00000029662	VEGA | MGI Sequence Detail	5922	Not Applicable
polypeptide	OTTMUSP00000013341	VEGA | MGI Sequence Detail	1728	Not Applicable

All sequences(72) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(217 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001739	Methyl-CpG DNA binding
Protein Ontology	PR:000031817	methyl-CpG-binding domain protein 5

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:192212 Du Y, et al., The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One. 2012;7(10):e47358
All references(39)

Other accession IDs

MGI:1924532, MGI:1924789, MGI:2138787, MGI:3705319