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Mbd5
Gene Detail
Symbol

Name
ID
Mbd5
methyl-CpG binding domain protein 5
MGI:2138934
Synonyms
9430004D19Rik, C030040A15Rik, OTTMUSG00000012483
Feature Type
protein coding gene
Genetic Map
Chromosome 2
28.43 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:48949510-49322284 bp, + strand
From VEGA annotation of GRCm38

  372775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81861  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mbd5

Human
homologs
Human Homolog MBD5, methyl-CpG binding domain protein 5
NCBI Gene ID 55777
neXtProt AC  NX_Q9P267
Human Synonyms  MRD1
Human Chr (Location)  2q23.1; chr2:148021011-148513477 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MBD5
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozgyous for a knock-out allele exhibit severe postnatal growth retardation leading to lethality by P22, decreased body, brain and liver weights, reduced IGF-I and GH levels, and abnormal glucose homeostasis.
 
Phenotype Images(2)
Interactions
Mbd5 interacts with 333 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process glucose homeostasis, nervous system development, ...
Component chromocenter, chromosome, ...
Function chromatin binding, DNA binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(45)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(1) cDNA(45)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000012482 (Evidence)
Ensembl Gene ModelENSMUSG00000036792 (Evidence)
Entrez Gene109241 (Evidence)
UniGene440436
DFCITC1601795, TC1593289, TC1734682, TC1602333
DoTSDT.55215665, DT.55183499, DT.101374051, DT.94124120, DT.91327156, DT.486251
NIA Mouse Gene IndexU001741, U042290
Consensus CDS ProjectCCDS38122.1, CCDS71051.1
International Mouse Knockout Project StatusMbd5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012482 VEGA Gene Model | MGI Sequence Detail 372775 C57BL/6J ±  kb
transcript OTTMUST00000029662 VEGA | MGI Sequence Detail 5922 Not Applicable 
polypeptide OTTMUSP00000013341 VEGA | MGI Sequence Detail 1728 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(13) UniProt(11)
Polymorphisms
SNPs within 2kb(1142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016177 DNA-binding, integrase-type
InterPro IPR001739 Methyl-CpG DNA binding
Protein Ontology PR:000031817 methyl-CpG-binding domain protein 5
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:212073 Camarena V, et al., Disruption of Mbd5 in mice causes neuronal functional deficits and neurobehavioral abnormalities consistent with 2q23.1 microdeletion syndrome. EMBO Mol Med. 2014;6(8):1003-15
All references(41)
Other
accession IDs
MGI:1924532, MGI:1924789, MGI:2138787, MGI:3705319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory