Tmem40 MGI Mouse Gene Detail - MGI:2137870

Symbol

Tmem40
Name

transmembrane protein 40
Synonyms

9030407H20Rik

Feature Type

protein coding gene
IDs

MGI:2137870
NCBI Gene: 94346
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:115706092-115739371 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 53.68 cM
Mapping Data

2 experiments

SNPs within 2kb

1557 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137870	protein coding gene	Chr6:115706092-115739427 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031153	protein coding gene	Chr6:118371086-118408831 (-)
A/J	MGP_AJ_G0031123	protein coding gene	Chr6:113823280-113858526 (-)
AKR/J	MGP_AKRJ_G0031053	protein coding gene	Chr6:116888228-116921044 (-)
BALB/cJ	MGP_BALBcJ_G0031133	protein coding gene	Chr6:113634132-113669557 (-)
C3H/HeJ	MGP_C3HHeJ_G0030575	protein coding gene	Chr6:67381494-67416025 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031592	protein coding gene	Chr6:121390842-121421050 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028756	protein coding gene	Chr6:110832084-110874503 (-)
CAST/EiJ	MGP_CASTEiJ_G0030240	protein coding gene	Chr6:117249621-117288293 (-)
CBA/J	MGP_CBAJ_G0030819	protein coding gene	Chr6:126157769-126194613 (-)
DBA/2J	MGP_DBA2J_G0030973	protein coding gene	Chr6:112750804-112786816 (-)
FVB/NJ	MGP_FVBNJ_G0030926	protein coding gene	Chr6:111928983-111964314 (-)
LP/J	MGP_LPJ_G0031052	protein coding gene	Chr6:118383414-118415525 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030961	protein coding gene	Chr6:130335316-130379676 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031620	protein coding gene	Chr6:116906065-116938046 (-)
PWK/PhJ	MGP_PWKPhJ_G0029956	protein coding gene	Chr6:111764734-111800629 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029784	protein coding gene	Chr6:115616469-115649059 (-)
WSB/EiJ	MGP_WSBEiJ_G0030324	protein coding gene	Chr6:117166492-117203539 (-)

Human Ortholog

TMEM40, transmembrane protein 40

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM40, transmembrane protein 40
Links

HGNC:25620

NCBI Gene ID: 55287

UniProt: Q8WWA1
Chr Location

3p25.2; chr3:12733528-12769457 (-) GRCh38

MGI Vertebrate Homology

Tmem40 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TMEM40
Gene Tree

Tmem40

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

34
Endonuclease-mediated

1
Gene trapped

30
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Tmem40
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available

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All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

7
cDNA Data

25
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem40

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All Sequences

65
RefSeq

20
UniProt

3
CCDS

CCDS39601.1, CCDS51878.1, CCDS51879.1

Ensembl

ENSMUSG00000059900 (Evidence)
NCBI Gene

94346

			Length	Strain/Species	Flank
genomic	ENSMUSG00000059900	Ensembl Gene Model \| MGI Sequence Detail	33280	C57BL/6J	± kb
transcript	ENSMUST00000112946	Ensembl \| MGI Sequence Detail	1554	Not Applicable
polypeptide	ENSMUSP00000108568	Ensembl \| MGI Sequence Detail	266	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029814 transmembrane protein 40

(term hierarchy)
InterPro Domains

IPR026181 Transmembrane protein 40

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All nucleic 25

cDNA 25

Microarray probesets 4

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MGI:2141619

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 11
Earliest

J:67747 Thut CJ, et al., A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Tmem40:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62533	Chr6:115739307-115739341 (-)	47 bp
Tssr62532	Chr6:115739283-115739305 (-)	77 bp
Tssr62531	Chr6:115735982-115735997 (-)	3,381 bp
Tssr62530	Chr6:115735965-115735981 (-)	3,398 bp
Tssr62529	Chr6:115735935-115735961 (-)	3,423 bp
Tssr62528	Chr6:115708059-115708076 (-)	31,303 bp
Tssr62527	Chr6:115708038-115708051 (-)	31,326 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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