Tg(Pcp2-cre)2Mpin
Transgene Detail

Summary

• Symbol: Tg(Pcp2-cre)2Mpin
• Name: transgene insertion 2, Max-Planck-Institute of Neurobiology
• MGI ID: MGI:2137515
• Synonyms: L7-cre, L7Cre-2, pcp2^Cre-2
• Transgene: Tg(Pcp2-cre)2Mpin Location: unknown
• Alliance: Tg(Pcp2-cre)2Mpin page

Purkinje cell degeneration in Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0 mice

Show the 7 phenotype image(s) involving this allele.

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:66884
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pcp2-cre)2Mpin expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pcp2

• Mutation details: These transgenic mice express Cre recombinase under the direction of the Purkinje cell-specific L7/Pcp2 promoter. Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons. Small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue. Recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth. (J:66884)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pcp2 (species not specified) Summary of all recombinase alleles driven by Pcp2. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:66884 Barski JJ, et al., Cre recombinase expression in cerebellar purkinje cells. Genesis. 2000 Nov-Dec;28(3-4):93-8
• All: 189 reference(s)