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P2rx5
Gene Detail
Symbol

Name
ID
P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
MGI:2137026
Synonyms
P2X5
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.25 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:73160421-73172685 bp, + strand
From VEGA annotation of GRCm38

  12265 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1924  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: P2RX5
Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx5

Human
homologs
P2RX5, purinergic receptor P2X, ligand gated ion channel, 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5026
neXtProt AC: NX_Q93086

Human Synonyms: LRH-1, P2X5, P2X5R

Human Chr (Location): 17p13.3; chr17:3673227-3696404 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving P2rx5 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit decreased peripheral blood CD8+ lymphocytes and elevated NK cells. Impaired learning/memory during trace aversive conditioning and increased exploratory behavior during open field testing is also seen.
 
Interactions
P2rx5 interacts with 145 markers (Mir7-2, Mir7b, Mir18b, ...)
Expression
Literature Summary: (1 records)
Data Summary: Results (50)    Tissues (42)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 42
Western blot 4
RT-PCR 4
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase p2rx5 ; ZFIN p2rx5    NEW 
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000006120 (Evidence)
Ensembl Gene Model ENSMUSG00000005950 (Evidence)
Entrez Gene 94045 (Evidence)
UniGene 156893
DFCI TC1587513
DoTS DT.91330893
NIA Mouse Gene Index U012896
Consensus CDS Project CCDS24998.1
International Mouse Phenotyping Consortium Status P2rx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006120 VEGA Gene Model | MGI Sequence Detail 12265 C57BL/6J ±  kb
transcript OTTMUST00000013836 VEGA | MGI Sequence Detail 2395 Not Applicable 
polypeptide OTTMUSP00000006416 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(7)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003048 P2X5 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012192 P2X purinoceptor 5
References
(Earliest) J:70144 Cox JA, et al., Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene. 2001 May 30;270(1-2):145-52
(Latest) J:197874 Guo W, et al., Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems. Purinergic Signal. 2013 Jun;9(2):239-48
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory