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P2rx5
Gene Detail
 Symbol
Name
ID
P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
MGI:2137026
Synonyms P2X5
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.25 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:73160421-73172685 bp, + strand
From VEGA annotation of GRCm38

  12265 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1924  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx5

Human
homologs
Human Homolog P2RX5, purinergic receptor P2X, ligand-gated ion channel, 5
NCBI Gene ID 5026
neXtProt AC  NX_Q93086
Human Synonyms  LRH-1, P2X5, P2X5R
Human Chr (Location)  17p13.3; chr17:3673227-3696404 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit decreased peripheral blood CD8+ lymphocytes and elevated NK cells. Impaired learning/memory during trace aversive conditioning and increased exploratory behavior during open field testing is also seen.
 
Interactions
P2rx5 interacts with 146 markers (Mir7-2, Mir7b, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cation transmembrane transport, cation transport, ...
Component integral component of membrane, integral component of nuclear inner membrane, ...
Function ATP binding, drug binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (50)    Tissues (42)   
Theiler Stages: 13, 15, 19, 21, 25
Assay TypeResults
Immunohistochemistry 42
Western blot 4
RT-PCR 4
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006120 (Evidence)
Ensembl Gene ModelENSMUSG00000005950 (Evidence)
Entrez Gene94045 (Evidence)
UniGene156893
DFCITC1587513
DoTSDT.91330893
NIA Mouse Gene IndexU012896
Consensus CDS ProjectCCDS24998.1
International Mouse Knockout Project StatusP2rx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006120 VEGA Gene Model | MGI Sequence Detail 12265 C57BL/6J ±  kb
transcript OTTMUST00000013836 VEGA | MGI Sequence Detail 2395 Not Applicable 
polypeptide OTTMUSP00000006416 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(7)
Polymorphisms SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003048 P2X5 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012192 P2X purinoceptor 5
References (Earliest) J:70144 Cox JA, et al., Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene. 2001 May 30;270(1-2):145-52
(Latest) J:197874 Guo W, et al., Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems. Purinergic Signal. 2013 Jun;9(2):239-48
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory