Acox2 Gene Detail

Summary

• Symbol
  Acox2
• Name
  acyl-Coenzyme A oxidase 2, branched chain

• Feature Type
  protein coding gene
• IDs
  MGI:1934852
  NCBI Gene: 93732
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr14:8225511-8259353 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    33843 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 4.77 cM, cytoband A1
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  ACOX2, acyl-CoA oxidase 2

• Vertebrate Orthologs
  9

• Human Ortholog
  ACOX2, acyl-CoA oxidase 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  BCOX, BRCACOX, BRCOX, CBAS6, THCCox
• Links
  HGNC:120

  NCBI Gene ID: 8309

  neXtProt AC: NX_Q99424

  UniProt: Q99424

  
  
• Chr Location
  3p14.3; chr3:58505136-58537202 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 74473
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: ACOX2
• Protein SuperFamily
  acyl-CoA oxidase
• Gene Tree
  Acox2
  

Human Diseases

• Diseases
  1 with human ACOX2 associations

				Human Disease	Mouse Models
				congenital bile acid synthesis defect 6 IDs congenital bile acid synthesis defect 6       DOID:0111067 OMIM:617308

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  5 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  1
• Targeted
  3
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  24 strains or lines available

Mice heterozygous for an endonuclease-mediated deletion exhibit no detectable phenotypic abnormalities.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  25
• GO References
  5

• External Resources
  FuncBase

Expression

• Assay Results
  68
• Tissues
  55
• cDNA Data
  43
• Literature Summary
  4

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase acox2

Interactions

• Acox2 interacts with 57 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

Sequences &
Gene Models

• All Sequences
  38
• RefSeq
  6
• UniProt
  3
• CCDS
  CCDS36801.1
• UniGene
  28700

• VEGA
  OTTMUSG00000035513 (Evidence)
• Ensembl
  ENSMUSG00000021751 (Evidence)
• NCBI Gene
  93732

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000035513	VEGA Gene Model | MGI Sequence Detail	33843	C57BL/6J
transcript	OTTMUST00000090946	VEGA | MGI Sequence Detail	2441	Not Applicable
polypeptide	OTTMUSP00000050024	VEGA | MGI Sequence Detail	681	Not Applicable

Polymorphisms

• SNPs within 2kb
  214 from dbSNP Build 142

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000003643 peroxisomal acyl-coenzyme A oxidase 2
  (term hierarchy)
• EC
  1.17.99.3
• InterPro Domains
  IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
  IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
  IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
  IPR012258 Acyl-CoA oxidase
  IPR002655 Acyl-CoA oxidase, C-terminal
  IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
  IPR029320 Acyl-coenzyme A oxidase, N-terminal
  IPR034171 Peroxisomal acyl-coenzyme A oxidase

Molecular
Reagents

• All nucleic 44

  cDNA 43

  Primer pair 1

  
  

  Microarray probesets 2

References

• Summaries
  All 30

  Developmental Gene Expression 4

  Gene Ontology 5

  Phenotypes 5
• Earliest
  J:67589 Huyghe S, et al., Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001 Feb 1;353(Pt 3):673-80
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42