Acox2 MGI Mouse Gene Detail - MGI:1934852 - acyl-Coenzyme A oxidase 2, branched chain

Acox2 Gene Detail

Symbol

Acox2
Name

acyl-Coenzyme A oxidase 2, branched chain

Feature Type

protein coding gene
IDs

MGI:1934852
NCBI Gene: 93732

Sequence Map

Chr14:8225511-8259353 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

33843 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 4.77 cM, cytoband A1
Mapping Data

1 experiment

Human Ortholog

ACOX2, acyl-CoA oxidase 2

Vertebrate Orthologs

9

Human Ortholog

ACOX2, acyl-CoA oxidase 2
Orthology source: HomoloGene, HGNC
Synonyms

BCOX, BRCACOX, BRCOX, CBAS6, THCCox
Links

HGNC:120

NCBI Gene ID: 8309

neXtProt AC: NX_Q99424

UniProt: Q99424
Chr Location

3p14.3; chr3:58505136-58537202 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 74473
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ACOX2
Protein SuperFamily

acyl-CoA oxidase
Gene Tree

Acox2

Diseases

1 with human ACOX2 associations

				Human Disease	Mouse Models
				congenital bile acid synthesis defect 6 IDs congenital bile acid synthesis defect 6 DOID:0111067 OMIM:617308

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available

Mice heterozygous for an endonuclease-mediated deletion exhibit no detectable phenotypic abnormalities.

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All GO Annotations

26
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

68
Tissues

55
cDNA Data

43
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Acox2 interacts with 57 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

38
RefSeq

6
UniProt

3
CCDS

CCDS36801.1
UniGene

28700

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035513	VEGA Gene Model \| MGI Sequence Detail	33843	C57BL/6J	± kb
transcript	OTTMUST00000090946	VEGA \| MGI Sequence Detail	2441	Not Applicable
polypeptide	OTTMUSP00000050024	VEGA \| MGI Sequence Detail	681	Not Applicable

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SNPs within 2kb

214 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000003643 peroxisomal acyl-coenzyme A oxidase 2

(term hierarchy)
EC

1.17.99.3
InterPro Domains

IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal

IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal

IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain

IPR012258 Acyl-CoA oxidase

IPR002655 Acyl-CoA oxidase, C-terminal

IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

IPR029320 Acyl-coenzyme A oxidase, N-terminal

IPR034171 Peroxisomal acyl-coenzyme A oxidase

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All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 5
Earliest

J:67589 Huyghe S, et al., Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001 Feb 1;353(Pt 3):673-80
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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