Acox2
Gene Detail

Symbol

Name
ID

Acox2
acyl-Coenzyme A oxidase 2, branched chain
MGI:1934852

Feature Type

protein coding gene

Genetic Map

Chromosome 14
4.77 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:8225511-8259353 bp, - strand From VEGA annotation of GRCm38   33843 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:74473  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: acyl-CoA oxidase
Gene Tree: Acox2

Human
homologs

Human Homolog		ACOX2, acyl-CoA oxidase 2, branched chain
NCBI Gene ID		8309
neXtProt AC		NX_Q99424
Human Synonyms		BCOX, BRCACOX, BRCOX, THCCox
Human Chr (Location)		3p14.3; chr3:58505136-58537202 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Acox2 interacts with 57 markers (Mir7-2, Mir7b, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (17 annotations)

Process	fatty acid beta-oxidation, fatty acid metabolic process, ...
Component	peroxisome
Function	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity, acyl-CoA dehydrogenase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (68)    Tissues (55)    Images (12)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	53
Northern blot	15

cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000035513 (Evidence)
Ensembl Gene Model	ENSMUSG00000021751 (Evidence)
Entrez Gene	93732 (Evidence)
UniGene	28700
DFCI	TC1581172
DoTS	DT.537949, DT.94351156
NIA Mouse Gene Index	U035228
EC	1.17.99.3
Consensus CDS Project	CCDS36801.1
International Mouse Knockout Project Status	Acox2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035513	VEGA Gene Model | MGI Sequence Detail	33843	C57BL/6J
transcript	OTTMUST00000090947	VEGA | MGI Sequence Detail	2907	Not Applicable
polypeptide	OTTMUSP00000050025	VEGA | MGI Sequence Detail	681	Not Applicable

All sequences(46) RefSeq(8) UniProt(5)

Polymorphisms

SNPs within 2kb(215 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009100	Acyl-CoA dehydrogenase/oxidase
InterPro	IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro	IPR012258	Acyl-CoA oxidase
InterPro	IPR002655	Acyl-CoA oxidase, C-terminal
InterPro	IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology	PR:000003643	peroxisomal acyl-coenzyme A oxidase 2

References

(Earliest) J:67589 Huyghe S, et al., Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001 Feb 1;353(Pt 3):673-80
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)