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Acox2 Gene Detail
Summary
  • Symbol
    Acox2
  • Name
    acyl-Coenzyme A oxidase 2, branched chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934852
    NCBI Gene: 93732
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:8225511-8259019 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 4.77 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934852
 protein coding gene Chr14:8225511-8259353 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020991
 protein coding gene Chr14:567470-602342 (-)
A/J MGP_AJ_G0020939
 protein coding gene Chr14:540058-574051 (-)
AKR/J MGP_AKRJ_G0020916
 protein coding gene Chr14:546644-580487 (-)
BALB/cJ MGP_BALBcJ_G0020941
 protein coding gene Chr14:535460-569687 (-)
C3H/HeJ MGP_C3HHeJ_G0020726
 protein coding gene Chr14:555957-589574 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021375
 protein coding gene Chr14:576571-610276 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018944
 protein coding gene Chr14:1455416-1489744 (-)
CAST/EiJ MGP_CASTEiJ_G0020248
 protein coding gene Chr14:552305-592006 (-)
CBA/J MGP_CBAJ_G0020692
 protein coding gene Chr14:598752-632446 (-)
DBA/2J MGP_DBA2J_G0020815
 protein coding gene Chr14:522319-556215 (-)
FVB/NJ MGP_FVBNJ_G0020797
 protein coding gene Chr14:520466-555429 (-)
LP/J MGP_LPJ_G0020892
 protein coding gene Chr14:546947-584156 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020823
 protein coding gene Chr14:578541-613616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021408
 protein coding gene Chr14:549768-584712 (-)
PWK/PhJ MGP_PWKPhJ_G0020000
 protein coding gene Chr14:549569-584291 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019821
 protein coding gene Chr14:558677-594510 (-)
WSB/EiJ MGP_WSBEiJ_G0020306
 protein coding gene Chr14:541965-576197 (-)



Homology
more
  • Human Ortholog
    ACOX2, acyl-CoA oxidase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACOX2, acyl-CoA oxidase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCOX, BRCACOX, BRCOX, CBAS6, THCCox
  • Links
    NCBI Gene ID: 8309
    neXtProt AC: NX_Q99424
    UniProt: Q99424

  • Chr Location
    3p14.3; chr3:58505136-58537202 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human ACOX2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice heterozygous for an endonuclease-mediated deletion exhibit no detectable phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    68
  • Tissues
    55
  • cDNA Data
    44
  • Literature Summary
    4
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 93732 NCBI Gene Model | MGI Sequence Detail 33509 C57BL/6J ±  kb
transcript NM_053115 RefSeq | MGI Sequence Detail 2573 C57BL/6  
polypeptide Q9QXD1 UniProt | EBI | MGI Sequence Detail 681 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003643 peroxisomal acyl-coenzyme A oxidase 2
    (term hierarchy)
  • EC
    1.17.99.3
  • InterPro Domains
    IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
    IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
    IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
    IPR012258 Acyl-CoA oxidase
    IPR002655 Acyl-CoA oxidase, C-terminal
    IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
    IPR029320 Acyl-coenzyme A oxidase, N-terminal
    IPR034171 Peroxisomal acyl-coenzyme A oxidase
Molecular
Reagents
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  • All nucleic 45
    cDNA 44
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:67589 Huyghe S, et al., Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001 Feb 1;353(Pt 3):673-80
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/06/2018
MGI 6.13 		The Jackson Laboratory