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Pip4k2b Gene Detail
Summary
  • Symbol
    Pip4k2b
  • Name
    phosphatidylinositol-5-phosphate 4-kinase, type II, beta
  • Synonyms
    c11, PI5P4Kbeta, Pip5k2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934234
    NCBI Gene: 108083
  • Gene Overview
    MyGene.info: PIP4K2B
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97715157-97744704 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934234
protein coding gene Chr11:97715157-97744704 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019038
protein coding gene Chr11:100173309-100208167 (-)
A/J MGP_AJ_G0019006
protein coding gene Chr11:96038436-96067833 (-)
AKR/J MGP_AKRJ_G0018976
protein coding gene Chr11:99022757-99051893 (-)
BALB/cJ MGP_BALBcJ_G0018979
protein coding gene Chr11:96539204-96569012 (-)
C3H/HeJ MGP_C3HHeJ_G0018793
protein coding gene Chr11:99140183-99176204 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019432
protein coding gene Chr11:103264851-103297672 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017063
protein coding gene Chr11:93494602-93525749 (-)
CAST/EiJ MGP_CASTEiJ_G0018347
protein coding gene Chr11:100005063-100036616 (-)
CBA/J MGP_CBAJ_G0018764
protein coding gene Chr11:107530938-107560134 (-)
DBA/2J MGP_DBA2J_G0018872
protein coding gene Chr11:95588976-95618598 (-)
FVB/NJ MGP_FVBNJ_G0018861
protein coding gene Chr11:95086203-95115464 (-)
LP/J MGP_LPJ_G0018942
protein coding gene Chr11:100680012-100711733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018888
protein coding gene Chr11:107370463-107400519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019472
protein coding gene Chr11:99327491-99358126 (-)
PWK/PhJ MGP_PWKPhJ_G0018119
protein coding gene Chr11:96576118-96605904 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017909
protein coding gene Chr11:99040150-99072588 (-)
WSB/EiJ MGP_WSBEiJ_G0018397
protein coding gene Chr11:99229643-99258695 (-)



Homology
more
  • Human Ortholog
    PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB
  • Links
    NCBI Gene ID: 8396
    neXtProt AC: NX_P78356
    UniProt: P78356

  • Chr Location
    17q12; chr17:38765691-38799965 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are smaller than normal with less body fat and an increased sensitivity to insulin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108083 NCBI Gene Model | MGI Sequence Detail 29548 C57BL/6J ±  kb
    transcript NM_054051 RefSeq | MGI Sequence Detail 5068 Not Specified  
    polypeptide Q80XI4 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012742 phosphatidylinositol 5-phosphate 4-kinase type-2 beta
    • EC
    • InterPro Domains
      IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
      IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
      IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
      IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 80
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144293
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:38804 Castellino AM, et al., A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1997 Feb 28;272(9):5861-70
    • Latest
      J:262397 Lundquist MR, et al., Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell. 2018 May 3;70(3):531-544.e9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory