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Pip4k2b
Gene Detail
 Symbol
Name
ID
Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
MGI:1934234
Synonyms c11, PI5P4Kbeta, Pip5k2b
Feature Type protein coding gene
Genetic Map
Chromosome 11
61.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:97715157-97744704 bp, - strand
From VEGA annotation of GRCm38

  29548 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2634  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip4k2b

Human
homologs
Human Homolog PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase, type II, beta
NCBI Gene ID 8396
neXtProt AC  NX_P78356
Human Synonyms  PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta
Human Chr (Location)  17q12; chr17:38765689-38799905 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are smaller than normal with less body fat and an increased sensitivity to insulin.
 
Interactions
Pip4k2b interacts with 345 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process phosphatidylinositol metabolic process, phosphatidylinositol phosphorylation, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (228)    Tissues (145)    Images (32)
Theiler Stages: 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 227
Northern blot 1
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) cDNA(79) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000002742 (Evidence)
Ensembl Gene ModelENSMUSG00000018547 (Evidence)
Entrez Gene108083 (Evidence)
UniGene39700
DFCITC1603119, TC1628493, TC1629915, TC1681269
DoTSDT.101318691, DT.101377090, DT.526451
NIA Mouse Gene IndexU033347
EC2.7.1.149
Consensus CDS ProjectCCDS25329.1
International Mouse Knockout Project StatusPip4k2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002742 VEGA Gene Model | MGI Sequence Detail 29548 C57BL/6J ±  kb
transcript OTTMUST00000005447 VEGA | MGI Sequence Detail 5053 Not Applicable 
polypeptide OTTMUSP00000002594 VEGA | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology PR:000012742 phosphatidylinositol 5-phosphate 4-kinase type-2 beta
References (Earliest) J:38804 Castellino AM, et al., A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1997 Feb 28;272(9):5861-70
(Latest) J:205288 Emerling BM, et al., Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7;155(4):844-57
All references(42)
Other
accession IDs
MGI:2144293

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory