Pip4k2b
Gene Detail

Symbol Name ID

Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta MGI:1934234

Synonyms

c11, PI5P4Kbeta, Pip5k2b

Feature Type

protein coding gene

Genetic Map

Chromosome 11

61.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:97715157-97744704 bp, - strand From VEGA annotation of GRCm38   29548 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2634  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip4k2b

Human homologs

Human Homolog		PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase, type II, beta
NCBI Gene ID		8396
neXtProt AC		NX_P78356
Human Synonyms		PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta
Human Chr (Location)		17q12; chr17:36921944-36956158 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(2) Gene trapped(16)
 

Mice homozygous for disruptions in this gene are smaller than normal with less body fat and an increased sensitivity to insulin.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	phosphatidylinositol metabolic process, phosphatidylinositol phosphorylation, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (228)    Tissues (144)    Images (32)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	227
Northern blot	1

cDNA source data(82)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(83) cDNA(82) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000002742 (Evidence)
Ensembl Gene Model	ENSMUSG00000018547 (Evidence)
Entrez Gene	108083 (Evidence)
UniGene	39700
DFCI	TC1603119, TC1628493, TC1629915, TC1681269
DoTS	DT.101318691, DT.101377090, DT.526451
NIA Mouse Gene Index	U033347
EC	2.7.1.149
Consensus CDS Project	CCDS25329.1
International Mouse Knockout Project Status	Pip4k2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002742	VEGA Gene Model | MGI Sequence Detail	29548	C57BL/6J
transcript	OTTMUST00000005447	VEGA | MGI Sequence Detail	5053	Not Applicable
polypeptide	OTTMUSP00000002594	VEGA | MGI Sequence Detail	416	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(84 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023610	Phosphatidylinositol-4-phosphate 5-kinase
InterPro	IPR002498	Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro	IPR016034	Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro	IPR027483	Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro	IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology	PR:000012742	phosphatidylinositol-5-phosphate 4-kinase type-2 beta

References

(Earliest) J:38804 Castellino AM, et al., A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1997 Feb 28;272(9):5861-70
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)

Other accession IDs

MGI:2144293