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Pip4k2b Gene Detail
Summary
  • Symbol
    Pip4k2b
  • Name
    phosphatidylinositol-5-phosphate 4-kinase, type II, beta
  • Synonyms
    c11, PI5P4Kbeta, Pip5k2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934234
    NCBI Gene: 108083
  • Gene Overview
    MyGene.info: PIP4K2B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:97715157-97744704 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29548 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.07 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB
  • Links
    NCBI Gene ID: 8396
    neXtProt AC: NX_P78356
    UniProt: P78356

  • Chr Location
    17q12; chr17:38765691-38799965 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are smaller than normal with less body fat and an increased sensitivity to insulin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002742 VEGA Gene Model | MGI Sequence Detail 29548 C57BL/6J ±  kb
    transcript OTTMUST00000005447 VEGA | MGI Sequence Detail 5053 Not Applicable  
    polypeptide OTTMUSP00000002594 VEGA | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      122 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012742 phosphatidylinositol 5-phosphate 4-kinase type-2 beta
    • EC
    • InterPro Domains
      IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
      IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
      IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
      IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
    Molecular
    Reagents
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    • All nucleic 81
      cDNA 80
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144293
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:38804 Castellino AM, et al., A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1997 Feb 28;272(9):5861-70
    • Latest
      J:262397 Lundquist MR, et al., Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell. 2018 May 3;70(3):531-544.e9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory