Jam2
Gene Detail

Symbol Name ID

Jam2 junction adhesion molecule 2 MGI:1933820

Synonyms

2410030G21Rik, 2410167M24Rik, JAM-2, Jcam2, VE-JAM

Feature Type

protein coding gene

Genetic Map

Chromosome 16

46.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:84774123-84825928 bp, + strand From VEGA annotation of GRCm38   51806 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Jam2

Human homologs

Human Homolog		JAM2, junctional adhesion molecule 2
NCBI Gene ID		58494
neXtProt AC		NX_P57087
Human Synonyms		C21orf43, CD322, JAMB, JAM-B, PRO245, VEJAM, VE-JAM
Human Chr (Location)		21q21.2; chr21:27011594-27089874 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(340) : Targeted(3) Gene trapped(337)
 

Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no detectable spermatogenesis abnormalities or defects in embryonic, neural and hematopoietic stem cell properties.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	negative regulation of cell adhesion
Component	cell junction, integral to membrane, ...
Function	protein heterodimerization activity

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (246)    Tissues (136)    Images (13)
Theiler Stages: 2, 3, 13, 15, 17, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	186
RT-PCR	60

cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) cDNA(45) Primer pair(5)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000025168 (Evidence)
Ensembl Gene Model	ENSMUSG00000053062 (Evidence)
Entrez Gene	67374 (Evidence)
UniGene	41758
DFCI	TC1581441, TC1594484, TC1643621, TC1666213
DoTS	DT.101313000, DT.40151007, DT.55261686, DT.87025888
NIA Mouse Gene Index	U108508
Consensus CDS Project	CCDS37381.1
International Mouse Knockout Project Status	Jam2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025168	VEGA Gene Model | MGI Sequence Detail	51806	C57BL/6J
transcript	OTTMUST00000061926	VEGA | MGI Sequence Detail	4370	Not Applicable
polypeptide	OTTMUSP00000030469	VEGA | MGI Sequence Detail	298	Not Applicable

All sequences(43) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(248 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001872	junctional adhesion molecule B

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:190703 Arcangeli ML, et al., The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis. FEBS Lett. 2012 Nov 16;586(22):4046-51
All references(53)

Other accession IDs

MGI:1914168, MGI:1924075, MGI:2146545