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Bicc1
Gene Detail
 Symbol
Name
ID
Bicc1
bicaudal C homolog 1 (Drosophila)
MGI:1933388
Synonyms Bic-C, jcpk
Feature Type protein coding gene
Genetic Map
Chromosome 10
36.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr10:70922832-71159700 bp, - strand
From VEGA annotation of GRCm38

  236869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bicc1

Human
homologs
Human Homolog BICC1, BicC family RNA binding protein 1
NCBI Gene ID 80114
neXtProt AC  NX_Q9H694
Human Synonyms  BICC, CYSRD
Human Chr (Location)  10q21.1; chr10:58513016-58831435 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human BICC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(3) Chemically induced (other)(2) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes heteroxia, impaired nodal flow, ventricular septal defects, partial prenatal lethality and postnatal death due to renal failure. Chemically induced mutants develop kidney cysts and may show bulging abdomens, bile duct anomalies and cardiovascular defects.
 
Human Diseases Modeled Using Mouse Bicc1 (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(15)
Interactions
Bicc1 interacts with 292 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process multicellular organismal development, negative regulation of canonical Wnt signaling pathway
Component cytoplasm
Function poly(A) RNA binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (133)    Tissues (94)    Images (44)
Theiler Stages: 9, 10, 11, 12, 14, 16, 18, 19, 20, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 97
Northern blot 30
RT-PCR 6
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024769 (Evidence)
Ensembl Gene ModelENSMUSG00000014329 (Evidence)
Entrez Gene83675 (Evidence)
Consensus CDS ProjectCCDS23915.1
International Mouse Knockout Project StatusBicc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024769 VEGA Gene Model | MGI Sequence Detail 236869 C57BL/6J ±  kb
transcript OTTMUST00000060990 VEGA | MGI Sequence Detail 5431 Not Applicable 
polypeptide OTTMUSP00000029836 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(1820 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
Protein Ontology PR:000004744 protein bicaudal C homolog 1
References (Earliest) J:27506 Flaherty L, et al., Chlorambucil-induced mutations in mice recovered in homozygotes. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2859-63
(Latest) J:179895 Weiss J, et al., ENU mutagenesis in mice identifies candidate genes for hypogonadism. Mamm Genome. 2012 Jan 19;
All references(50)
Disease annotation references (6)
Other
accession IDs
MGD-MRK-11521, MGD-MRK-18744, MGI:101915, MGI:96633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory