Bicc1
Gene Detail

Symbol Name ID

Bicc1 bicaudal C homolog 1 (Drosophila) MGI:1933388

Synonyms

Bic-C, jcpk

Feature Type

protein coding gene

Genetic Map

Chromosome 10

36.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr10:70922832-71159700 bp, - strand From VEGA annotation of GRCm38   236869 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bicc1

Human homologs

Human Homolog		BICC1, bicaudal C homolog 1 (Drosophila)
NCBI Gene ID		80114
neXtProt AC		NX_Q9H694
Human Synonyms		BICC, CYSRD
Human Chr (Location)		10q21.1; chr10:60272904-60588845 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human BICC1

Alleles and phenotypes

All alleles(8) : Targeted(2) Spontaneous(1) Chemically induced(5)
 

Homozygous mutant mice display polycystic kidneys with distended abdomens, abnormal bile duct morphology, and die either postnatally or shortly after weaning.

 
Human Diseases Modeled Using Mouse Bicc1 (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(15)

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	multicellular organismal development, negative regulation of canonical Wnt receptor signaling pathway
Function	RNA binding

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (133)    Tissues (85)    Images (44)
Theiler Stages: 9, 10, 11, 12, 14, 16, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	97
Northern blot	30
RT-PCR	6

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000024769 (Evidence)
Ensembl Gene Model	ENSMUSG00000014329 (Evidence)
Entrez Gene	83675 (Evidence)
Consensus CDS Project	CCDS23915.1
International Mouse Knockout Project Status	Bicc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024769	VEGA Gene Model | MGI Sequence Detail	236869	C57BL/6J
transcript	OTTMUST00000060990	VEGA | MGI Sequence Detail	5431	Not Applicable
polypeptide	OTTMUSP00000029836	VEGA | MGI Sequence Detail	977	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1269 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004087	K Homology domain
InterPro	IPR004088	K Homology domain, type 1
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
Protein Ontology	PR:000004744	protein bicaudal C 1

References

(Earliest) J:27506 Flaherty L, et al., Chlorambucil-induced mutations in mice recovered in homozygotes. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2859-63
(Latest) J:179895 Weiss J, et al., ENU mutagenesis in mice identifies candidate genes for hypogonadism. Mamm Genome. 2012 Jan 19;
All references(50)

Other accession IDs

MGD-MRK-11521, MGD-MRK-18744, MGI:101915, MGI:96633