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Bicc1 Gene Detail
Summary
  • Symbol
    Bicc1
  • Name
    BicC family RNA binding protein 1
  • Synonyms
    Bic-C, jcpk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933388
    NCBI Gene: 83675
Location & Maps
more
  • Sequence Map
    Chr10:70922832-71159700 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      236869 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 36.75 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    BICC1, BicC family RNA binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BICC1, BicC family RNA binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BICC, CYSRD
  • Links
    NCBI Gene ID: 80114
    neXtProt AC: NX_Q9H694

  • Chr Location
    10q21.1; chr10:58512916-58831437 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12856
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BICC1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Bicc1 mouse models; 1 with human BICC1 associations

Human Disease Mouse Models
       Heterotaxy, Visceral, 5, Autosomal; HTX5   OMIM: 270100 View 1 model
Polycystic Kidney Disease 1; PKD1   OMIM: 173900 View 1 model
Polycystic Kidney Disease, Autosomal Recessive; ARPKD   OMIM: 263200 View 6 models
       Renal Dysplasia, Cystic, Susceptibility To; CYSRD   OMIM: 601331
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 7 alleles in 11 genetic backgrounds
    15 phenotypes from multigenic genotypes
    15 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    3
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Bicc1
  • Incidental Mutations
Homozygous inactivation of this gene causes heteroxia, impaired nodal flow, ventricular septal defects, partial prenatal lethality and postnatal death due to renal failure. Chemically induced mutants develop kidney cysts and may show bulging abdomens, bile duct anomalies and cardiovascular defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024769 VEGA Gene Model | MGI Sequence Detail 236869 C57BL/6J ±  kb
transcript OTTMUST00000060990 VEGA | MGI Sequence Detail 5431 Not Applicable  
polypeptide OTTMUSP00000029836 VEGA | MGI Sequence Detail 977 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1819 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 13
    Primer pair 3
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-11521, MGD-MRK-18744, MGI:101915, MGI:96633
References
more
  • Summaries
    All 57
    Developmental Gene Expression 11
    Diseases 6
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:27506 Flaherty L, et al., Chlorambucil-induced mutations in mice recovered in homozygotes. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2859-63
  • Latest
    J:228224 Rothe B, et al., Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA. Mol Cell Biol. 2015 Oct;35(19):3339-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory