About   Help   FAQ
Impa1 Gene Detail
Summary
  • Symbol
    Impa1
  • Name
    inositol (myo)-1(or 4)-monophosphatase 1
  • Synonyms
    2610002K09Rik, 2900059K10Rik, lithium-sensitive myo-inositol monophosphatase A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933158
    NCBI Gene: 55980
  • Gene Overview
    MyGene.info: IMPA1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:10311956-10331439 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 2.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933158
protein coding gene Chr3:10311956-10331439 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027065
protein coding gene Chr3:7292793-7312483 (-)
A/J MGP_AJ_G0027029
protein coding gene Chr3:7443408-7463183 (-)
AKR/J MGP_AKRJ_G0026999
protein coding gene Chr3:7352493-7371976 (-)
BALB/cJ MGP_BALBcJ_G0027038
protein coding gene Chr3:7139024-7158570 (-)
C3H/HeJ MGP_C3HHeJ_G0026778
protein coding gene Chr3:7649133-7668679 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027482
protein coding gene Chr3:7926003-7945507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024844
protein coding gene Chr3:6322084-6341147 (-)
CAST/EiJ MGP_CASTEiJ_G0026236
protein coding gene Chr3:7677062-7696725 (-)
CBA/J MGP_CBAJ_G0026756
protein coding gene Chr3:7937684-7957230 (-)
DBA/2J MGP_DBA2J_G0026892
protein coding gene Chr3:7002588-7022168 (-)
FVB/NJ MGP_FVBNJ_G0026859
protein coding gene Chr3:6933745-6954416 (-)
LP/J MGP_LPJ_G0027002
protein coding gene Chr3:7809140-7828623 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026880
protein coding gene Chr3:8965264-8984942 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027542
protein coding gene Chr3:7211616-7231395 (-)
PWK/PhJ MGP_PWKPhJ_G0025971
protein coding gene Chr3:7235279-7255325 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025774
protein coding gene Chr3:7348829-7370033 (-)
WSB/EiJ MGP_WSBEiJ_G0026307
protein coding gene Chr3:7239131-7258813 (-)



Homology
more
  • Human Ortholog
    IMPA1, inositol monophosphatase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IMPA1, inositol monophosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMP, IMPA, MRT59
  • Links
    NCBI Gene ID: 3612
    neXtProt AC: NX_P29218
    UniProt: P29218

  • Chr Location
    8q21.13; chr8:81656916-81686354 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele die between E9.5 and E10.5 with surviving mice exhibiting hyperactivity, increased rearing, and increased susceptibility to pilocarpine-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 55980 NCBI Gene Model | MGI Sequence Detail 19484 C57BL/6J ±  kb
transcript NM_018864 RefSeq | MGI Sequence Detail 4185 C57BL/6  
polypeptide O55023 UniProt | EBI | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 127
    cDNA 125
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914387, MGI:1920227, MGI:2139682
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:250420 Ohnishi T, et al., Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. J Biol Chem. 2014 Apr 11;289(15):10785-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory