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Impa1
Gene Detail
Symbol

Name
ID
Impa1
inositol (myo)-1(or 4)-monophosphatase 1
MGI:1933158
Synonyms
2610002K09Rik, 2900059K10Rik, lithium-sensitive myo-inositol monophosphatase A1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:10311956-10331439 bp, - strand
From VEGA annotation of GRCm38

  19484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4043  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IMPA1
Protein SuperFamily: metal-dependent/Li(+)-inhibited phosphomonoesterase
Gene Tree: Impa1

Human
homologs
IMPA1, inositol(myo)-1(or 4)-monophosphatase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3612
neXtProt AC: NX_P29218

Human Synonyms: IMP, IMPA

Human Chr (Location): 8q21.13-q21.3; chr8:81656916-81686354 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Most mice homozygous for a knock-out allele die between E9.5 and E10.5 with surviving mice exhibiting hyperactivity, increased rearing, and increased susceptibility to pilocarpine-induced seizures.
 
Interactions
Impa1 interacts with 202 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process inositol metabolic process, inositol phosphate dephosphorylation, ...
Component axon, cytoplasm, ...
Function hydrolase activity, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (97)    Tissues (97)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 3
cDNA source data(123)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase impa1    NEW 
Molecular
reagents
All nucleic(124) cDNA(123) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027767 (Evidence)
Ensembl Gene Model ENSMUSG00000027531 (Evidence)
Entrez Gene 55980 (Evidence)
UniGene 183042
DFCI TC1572524, TC1592889, TC1720622
DoTS DT.55170253, DT.495054, DT.97348981, DT.94290852
NIA Mouse Gene Index U023831
EC 3.1.3.25, 3.1.3.94
PDB 4AS5
Consensus CDS Project CCDS17240.1
International Mouse Phenotyping Consortium Status Impa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027767 VEGA Gene Model | MGI Sequence Detail 19484 C57BL/6J ±  kb
transcript OTTMUST00000068723 VEGA | MGI Sequence Detail 4185 Not Applicable 
polypeptide OTTMUSP00000034806 VEGA | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(8)
Polymorphisms
SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000760 Inositol monophosphatase
InterPro IPR020550 Inositol monophosphatase, conserved site
InterPro IPR020552 Inositol monophosphatase, Lithium-sensitive
InterPro IPR020583 Inositol monophosphatase, metal-binding site
Protein Ontology PR:000009017 inositol monophosphatase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193924 Ohnishi T, et al., Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. 2013 Mar;124(5):685-94
All references(41)
Other
accession IDs
MGI:1914387, MGI:1920227, MGI:2139682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory