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Impa1
Gene Detail
Symbol

Name
ID
Impa1
inositol (myo)-1(or 4)-monophosphatase 1
MGI:1933158
Synonyms
2610002K09Rik, 2900059K10Rik, lithium-sensitive myo-inositol monophosphatase A1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:10313540-10331439 bp, - strand
From VEGA annotation of GRCm38

  17900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4043  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: metal-dependent/Li(+)-inhibited phosphomonoesterase
Gene Tree: Impa1

Human
homologs
Human Homolog IMPA1, inositol(myo)-1(or 4)-monophosphatase 1
NCBI Gene ID 3612
neXtProt AC  NX_P29218
Human Synonyms  IMP, IMPA
Human Chr (Location)  8q21.13-q21.3; chr8:81656916-81686354 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Most mice homozygous for a knock-out allele die between E9.5 and E10.5 with surviving mice exhibiting hyperactivity, increased rearing, and increased susceptibility to pilocarpine-induced seizures.
 
Interactions
Impa1 interacts with 203 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process inositol metabolic process, inositol phosphate dephosphorylation, ...
Component axon, cytoplasm, ...
Function hydrolase activity, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (97)    Tissues (97)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 3
cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(123) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027767 (Evidence)
Ensembl Gene ModelENSMUSG00000027531 (Evidence)
Entrez Gene55980 (Evidence)
UniGene183042
DFCITC1572524, TC1592889, TC1720622
DoTSDT.495054, DT.55170253, DT.94290852, DT.97348981
NIA Mouse Gene IndexU023831
EC3.1.3.25
PDB4AS5
Consensus CDS ProjectCCDS17240.1
International Mouse Knockout Project StatusImpa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027767 VEGA Gene Model | MGI Sequence Detail 17900 C57BL/6J ±  kb
transcript OTTMUST00000068723 VEGA | MGI Sequence Detail 2601 Not Applicable 
polypeptide OTTMUSP00000034806 VEGA | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000760 Inositol monophosphatase
InterPro IPR020550 Inositol monophosphatase, conserved site
InterPro IPR020552 Inositol monophosphatase, Lithium-sensitive
InterPro IPR020583 Inositol monophosphatase, metal-binding site
Protein Ontology PR:000009017 inositol monophosphatase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193924 Ohnishi T, et al., Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. 2013 Mar;124(5):685-94
All references(44)
Other
accession IDs
MGI:1914387, MGI:1920227, MGI:2139682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory