Akap12 MGI Mouse Gene Detail - MGI:1932576 - A kinase (PRKA) anchor protein (gravin) 12

Symbol

Akap12
Name

A kinase (PRKA) anchor protein (gravin) 12
Synonyms

Srcs5, SSeCKS, Tsga12

Feature Type

protein coding gene
IDs

MGI:1932576
NCBI Gene: 83397
Gene Overview

MyGene.info: AKAP12
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:4266380-4359470 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 2.06 cM
Mapping Data

3 experiments

SNPs within 2kb

656 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932576	protein coding gene	Chr10:4266329-4359471 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016976	protein coding gene	Chr10:1243582-1347720 (+)
A/J	MGP_AJ_G0016954	protein coding gene	Chr10:1184578-1280055 (+)
AKR/J	MGP_AKRJ_G0016919	protein coding gene	Chr10:1170036-1269790 (+)
BALB/cJ	MGP_BALBcJ_G0016912	protein coding gene	Chr10:1156547-1251512 (+)
C3H/HeJ	MGP_C3HHeJ_G0016737	protein coding gene	Chr10:1260007-1363066 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017375	protein coding gene	Chr10:1253807-1367214 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015081	protein coding gene	Chr10:1017301-1107721 (+)
CAST/EiJ	MGP_CASTEiJ_G0016319	protein coding gene	Chr10:1294076-1401003 (+)
CBA/J	MGP_CBAJ_G0016709	protein coding gene	Chr10:1290645-1396856 (+)
DBA/2J	MGP_DBA2J_G0016817	protein coding gene	Chr10:1188129-1283398 (+)
FVB/NJ	MGP_FVBNJ_G0016812	protein coding gene	Chr10:1144602-1241901 (+)
LP/J	MGP_LPJ_G0016892	protein coding gene	Chr10:1248866-1345213 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016843	protein coding gene	Chr10:1243209-1342515 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017412	protein coding gene	Chr10:1185756-1287742 (+)
PWK/PhJ	MGP_PWKPhJ_G0016105	protein coding gene	Chr10:1187524-1280222 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015886	protein coding gene	Chr10:1372626-1460887 (+)
WSB/EiJ	MGP_WSBEiJ_G0016380	protein coding gene	Chr10:1226727-1349789 (+)

Human Ortholog

AKAP12, A-kinase anchoring protein 12

Vertebrate Orthologs

7

Human Ortholog

AKAP12, A-kinase anchoring protein 12
Orthology source: HomoloGene, HGNC
Synonyms

AKAP250, SSeCKS
Links

HGNC:370

NCBI Gene ID: 9590

neXtProt AC: NX_Q02952

UniProt: Q02952
Chr Location

6q25.1; chr6:151239815-151358559 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3740
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: AKAP12
Gene Tree

Akap12

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Phenotype Summary

25 phenotypes from 3 alleles in 3 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

313
Gene trapped

310
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

156 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function.

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All GO Annotations

29
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

700
Tissues

46
cDNA Data

258
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AKAP12

Xenbase akap12

ZFIN akap12b

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Akap12 interacts with 284 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

56
RefSeq

2
UniProt

6
CCDS

CCDS56673.1
UniGene

27481

Ensembl

ENSMUSG00000038587 (Evidence)
NCBI Gene

83397

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038587	Ensembl Gene Model \| MGI Sequence Detail	93091	C57BL/6J	± kb
transcript	ENSMUST00000045730	Ensembl \| MGI Sequence Detail	6195	Not Applicable
polypeptide	ENSMUSP00000035829	Ensembl \| MGI Sequence Detail	1684	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003886 A-kinase anchor protein 12

(term hierarchy)
InterPro Domains

IPR001573 A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif

IPR028540 A-kinase anchor protein 12

IPR018459 RII binding domain

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All nucleic 260

cDNA 259

Primer pair 1

Microarray probesets 3

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MGD-MRK-26034, MGI:104598, MGI:1194895, MGI:2143574

Summaries

All 65

Developmental Gene Expression 13

Gene Ontology 6

Phenotypes 22
Earliest

J:22534 Frankfort BJ, et al., Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995 Jan 26;206(3):916-26
Latest

J:303551 Seo JH, et al., AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke. Int J Mol Sci. 2020 Nov 28;21(23)

TSS for Akap12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92240	Chr10:4266323-4266341 (+)	-48 bp
Tssr92241	Chr10:4266353-4266374 (+)	-16 bp
Tssr3114	Chr10:4266530-4266531 (+)	151 bp
Tssr92248	Chr10:4346789-4346802 (+)	80,416 bp
Tssr92249	Chr10:4346807-4346873 (+)	80,460 bp
Tssr92250	Chr10:4347762-4347796 (+)	81,399 bp
Tssr92251	Chr10:4347811-4347822 (+)	81,437 bp
Tssr92252	Chr10:4353434-4353455 (+)	87,065 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/13/2021 MGI 6.16