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Akap12
Gene Detail
Symbol

Name
ID
Akap12
A kinase (PRKA) anchor protein (gravin) 12
MGI:1932576
Synonyms
Srcs5, SSeCKS, Tsga12
Feature Type
protein coding gene
Genetic Map
Chromosome 10
2.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:4266329-4359468 bp, + strand
From Ensembl annotation of GRCm38

  93140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Akap12

Human
homologs
Human Homolog AKAP12, A kinase (PRKA) anchor protein 12
NCBI Gene ID 9590
neXtProt AC  NX_Q02952
Human Synonyms  AKAP250, SSeCKS
Human Chr (Location)  6q24-q25; chr6:151239999-151358559 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(314) : Gene trapped(311) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function.
 
Interactions
Akap12 interacts with 285 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (66)    Tissues (44)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
cDNA source data(257)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(258) cDNA(258)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038587 (Evidence)
Entrez Gene83397 (Evidence)
UniGene27481
DFCITC1572749
DoTSDT.99851174, DT.489689, DT.101393237
NIA Mouse Gene IndexU078142
Consensus CDS ProjectCCDS56673.1
International Mouse Knockout Project StatusAkap12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038587 Ensembl Gene Model | MGI Sequence Detail 93140 C57BL/6J ±  kb
transcript ENSMUST00000045730 Ensembl | MGI Sequence Detail 6244 Not Applicable 
polypeptide ENSMUSP00000035829 Ensembl | MGI Sequence Detail 1684 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(664 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001573 Protein kinase A anchoring, WSK motif
InterPro IPR018459 RII binding domain
Protein Ontology PR:000003886 A-kinase anchor protein 12
References
(Earliest) J:22534 Frankfort BJ, et al., Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995 Jan 26;206(3):916-26
(Latest) J:215163 Cha JH, et al., AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 2014;9(4):e94695
All references(54)
Other
accession IDs
MGD-MRK-26034, MGI:104598, MGI:1194895, MGI:2143574

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory