Akap12
Gene Detail

Symbol

Name
ID

Akap12
A kinase (PRKA) anchor protein (gravin) 12
MGI:1932576

Synonyms

Srcs5, SSeCKS, Tsga12

Feature Type

protein coding gene

Genetic Map

Chromosome 10
2.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:4266329-4359468 bp, + strand From Ensembl annotation of GRCm38   93140 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:3740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Akap12

Human
homologs

Human Homolog		AKAP12, A kinase (PRKA) anchor protein 12
NCBI Gene ID		9590
neXtProt AC		NX_Q02952
Human Synonyms		AKAP250, SSeCKS
Human Chr (Location)		6q24-q25; chr6:151239999-151358559 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(314) : Gene trapped(311) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function.

 

Interactions

Akap12 interacts with 285 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (13 annotations)

Process	positive regulation of cAMP biosynthetic process, positive regulation of protein kinase A signaling, ...
Component	cytoplasm, cytoskeleton, ...
Function	adenylate cyclase binding, protein kinase A binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (66)    Tissues (44)    Images (17)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	66

cDNA source data(257)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(258) cDNA(258)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000038587 (Evidence)
Entrez Gene	83397 (Evidence)
UniGene	27481
DFCI	TC1572749
DoTS	DT.101393237, DT.489689, DT.99851174
NIA Mouse Gene Index	U078142
Consensus CDS Project	CCDS56673.1
International Mouse Knockout Project Status	Akap12

Sequences

Length	Strain/Species
genomic	ENSMUSG00000038587	Ensembl Gene Model | MGI Sequence Detail	93140	C57BL/6J
transcript	ENSMUST00000045730	Ensembl | MGI Sequence Detail	6244	Not Applicable
polypeptide	ENSMUSP00000035829	Ensembl | MGI Sequence Detail	1684	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs within 2kb(664 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001573	Protein kinase A anchoring, WSK motif
InterPro	IPR018459	RII binding domain
Protein Ontology	PR:000003886	A-kinase anchor protein 12

References

(Earliest) J:22534 Frankfort BJ, et al., Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995 Jan 26;206(3):916-26
(Latest) J:215163 Cha JH, et al., AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 2014;9(4):e94695
All references(55)

Other
accession IDs

MGD-MRK-26034, MGI:104598, MGI:1194895, MGI:2143574