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Akap12 Gene Detail
Summary
  • Symbol
    Akap12
  • Name
    A kinase anchor protein 12
  • Synonyms
    Srcs5, SSeCKS, Tsga12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932576
    NCBI Gene: 83397
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:4216380-4309470 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2960 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932576
 protein coding gene Chr10:4216329-4309471 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016976
 protein coding gene Chr10:1243582-1347720 (+)
A/J MGP_AJ_G0016954
 protein coding gene Chr10:1184578-1280055 (+)
AKR/J MGP_AKRJ_G0016919
 protein coding gene Chr10:1170036-1269790 (+)
BALB/cJ MGP_BALBcJ_G0016912
 protein coding gene Chr10:1156547-1251512 (+)
C3H/HeJ MGP_C3HHeJ_G0016737
 protein coding gene Chr10:1260007-1363066 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017375
 protein coding gene Chr10:1253807-1367214 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015081
 protein coding gene Chr10:1017301-1107721 (+)
CAST/EiJ MGP_CASTEiJ_G0016319
 protein coding gene Chr10:1294076-1401003 (+)
CBA/J MGP_CBAJ_G0016709
 protein coding gene Chr10:1290645-1396856 (+)
DBA/2J MGP_DBA2J_G0016817
 protein coding gene Chr10:1188129-1283398 (+)
FVB/NJ MGP_FVBNJ_G0016812
 protein coding gene Chr10:1144602-1241901 (+)
LP/J MGP_LPJ_G0016892
 protein coding gene Chr10:1248866-1345213 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016843
 protein coding gene Chr10:1243209-1342515 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017412
 protein coding gene Chr10:1185756-1287742 (+)
PWK/PhJ MGP_PWKPhJ_G0016105
 protein coding gene Chr10:1187524-1280222 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015886
 protein coding gene Chr10:1372626-1460887 (+)
WSB/EiJ MGP_WSBEiJ_G0016380
 protein coding gene Chr10:1226727-1349789 (+)



Homology
more
  • Human Ortholog
    AKAP12, A-kinase anchoring protein 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP12, A-kinase anchoring protein 12
  • Synonyms
    AKAP250, SSeCKS
  • Links
    NCBI Gene ID: 9590
    UniProt: Q02952

  • Chr Location
    6q25.1; chr6:151239967-151358559 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human AKAP12 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    49
  • cDNA Data
    260
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038587 Ensembl Gene Model | MGI Sequence Detail 93091 C57BL/6J ±  kb
    transcript ENSMUST00000045730 Ensembl | MGI Sequence Detail 6195 Not Applicable  
    polypeptide ENSMUSP00000035829 Ensembl | MGI Sequence Detail 1684 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003886 A-kinase anchor protein 12
      (term hierarchy)
    • InterPro Domains
      IPR001573 A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif
      IPR028540 A-kinase anchor protein 12
      IPR018459 RII binding domain
    • GlyGen
      Q9WTQ5 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 264
      cDNA 261
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26034, MGI:104598, MGI:1194895, MGI:2143574
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 17
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:22534 Frankfort BJ, et al., Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995 Jan 26;206(3):916-26
    • Latest
      J:366290 Qasim H, et al., AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12;134(8):1006-1022
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory