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Akap12
Gene Detail
 Symbol
Name
ID
Akap12
A kinase (PRKA) anchor protein (gravin) 12
MGI:1932576
Synonyms Srcs5, SSeCKS, Tsga12
Feature Type protein coding gene
Genetic Map
Chromosome 10
2.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:4266329-4359468 bp, + strand
From Ensembl annotation of GRCm38

  93140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Akap12

Human
homologs
Human Homolog AKAP12, A kinase (PRKA) anchor protein 12
NCBI Gene ID 9590
neXtProt AC  NX_Q02952
Human Synonyms  AKAP250, SSeCKS
Human Chr (Location)  6q24-q25; chr6:151239999-151358559 (+)  GRCh38
Alleles
and
phenotypes
All alleles(314) : Gene trapped(311) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process phosphorylation, positive regulation of cAMP biosynthetic process, ...
Component cytoplasm, cytoskeleton
Function adenylate cyclase binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (66)    Tissues (44)    Images (17)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 66
cDNA source data(257)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(258) cDNA(258)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038587 (Evidence)
Entrez Gene83397 (Evidence)
UniGene27481
DFCITC1572749
DoTSDT.101393237, DT.489689, DT.99851174
NIA Mouse Gene IndexU078142
Consensus CDS ProjectCCDS56673.1
International Mouse Knockout Project StatusAkap12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038587 Ensembl Gene Model | MGI Sequence Detail 93140 C57BL/6J ±  kb
transcript ENSMUST00000045730 Ensembl | MGI Sequence Detail 6244 Not Applicable 
polypeptide ENSMUSP00000035829 Ensembl | MGI Sequence Detail 1684 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(664 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001573 Protein kinase A anchoring, WSK motif
InterPro IPR018459 RII binding domain
Protein Ontology PR:000003886 A-kinase anchor protein 12
References (Earliest) J:22534 Frankfort BJ, et al., Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995 Jan 26;206(3):916-26
(Latest) J:209148 Ko HK, et al., A transgenic mouse model for early prostate metastasis to lymph nodes. Cancer Res. 2014 Feb 1;74(3):945-53
All references(53)
Other
accession IDs
MGD-MRK-26034, MGI:104598, MGI:1194895, MGI:2143574

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory