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Akap12
Gene Detail
Symbol

Name
ID
Akap12
A kinase (PRKA) anchor protein (gravin) 12
MGI:1932576
Synonyms
Srcs5, SSeCKS, Tsga12
Feature Type
protein coding gene
Genetic Map
Chromosome 10
2.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:4266329-4359468 bp, + strand
From Ensembl annotation of GRCm38

  93140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: AKAP12
Gene Tree: Akap12

Human
homologs
AKAP12, A kinase (PRKA) anchor protein 12
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9590
neXtProt AC: NX_Q02952

Human Synonyms: AKAP250, SSeCKS

Human Chr (Location): 6q24-q25; chr6:151239999-151358559 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(314) : Gene trapped(311) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function.
 
Interactions
Akap12 interacts with 284 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (66)    Tissues (44)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
cDNA source data(257)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA AKAP12 ; Xenbase akap12 ; ZFIN akap12b    NEW 
Molecular
reagents
All nucleic(258) cDNA(258)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000038587 (Evidence)
Entrez Gene 83397 (Evidence)
UniGene 27481
DFCI TC1572749
DoTS DT.101393237, DT.489689, DT.99851174
NIA Mouse Gene Index U078142
Consensus CDS Project CCDS56673.1
International Mouse Phenotyping Consortium Status Akap12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038587 Ensembl Gene Model | MGI Sequence Detail 93140 C57BL/6J ±  kb
transcript ENSMUST00000045730 Ensembl | MGI Sequence Detail 6244 Not Applicable 
polypeptide ENSMUSP00000035829 Ensembl | MGI Sequence Detail 1684 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(664 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028540 A-kinase anchor protein 12
InterPro IPR001573 Protein kinase A anchoring, WSK motif
InterPro IPR018459 RII binding domain
Protein Ontology PR:000003886 A-kinase anchor protein 12
References
(Earliest) J:22534 Frankfort BJ, et al., Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995 Jan 26;206(3):916-26
(Latest) J:215163 Cha JH, et al., AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 2014;9(4):e94695
All references(54)
Other
accession IDs
MGD-MRK-26034, MGI:104598, MGI:1194895, MGI:2143574

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory