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Akap12 Gene Detail
Summary
  • Symbol
    Akap12
  • Name
    A kinase (PRKA) anchor protein (gravin) 12
  • Synonyms
    Srcs5, SSeCKS, Tsga12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932576
    NCBI Gene: 83397
  • Gene Overview
    MyGene.info: AKAP12
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:4266380-4359470 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      93091 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.06 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AKAP12, A-kinase anchoring protein 12
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AKAP12, A-kinase anchoring protein 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AKAP250, SSeCKS
  • Links
    NCBI Gene ID: 9590
    neXtProt AC: NX_Q02952
    UniProt: Q02952

  • Chr Location
    6q25.1; chr6:151239815-151358559 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    66
  • Tissues
    44
  • cDNA Data
    258
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038587 Ensembl Gene Model | MGI Sequence Detail 93091 C57BL/6J ±  kb
    transcript ENSMUST00000045730 Ensembl | MGI Sequence Detail 6195 Not Applicable  
    polypeptide ENSMUSP00000035829 Ensembl | MGI Sequence Detail 1684 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      656 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 259
      cDNA 259

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26034, MGI:104598, MGI:1194895, MGI:2143574
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:22534 Frankfort BJ, et al., Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995 Jan 26;206(3):916-26
    • Latest
      J:253421 Li Z, et al., Force development and intracellular Ca(2+) in intact cardiac muscles from gravin mutant mice. Eur J Pharmacol. 2017 Jul 15;807:117-126
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory