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Pum1
Gene Detail
Symbol

Name
ID
Pum1
pumilio RNA-binding family member 1
MGI:1931749
Synonyms
mKIAA0099, Pumm
Feature Type
protein coding gene
Genetic Map
Chromosome 4
63.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:130663321-130781564 bp, + strand
From VEGA annotation of GRCm38

  118244 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PUM1
Gene Tree: Pum1

Human
homologs
PUM1, pumilio RNA-binding family member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9698
neXtProt AC: NX_Q14671

Human Synonyms: HSPUM, PUMH, PUMH1, PUML1

Human Chr (Location): 1p35.2; chr1:30931506-31065717 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(316) : Gene trapped(310) Targeted(6)
Genomic Mutations involving Pum1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased testes weight and size, decreased body weight, oligozoospermia, reduced male fertility, increased male germ cell apoptosis and small seminiferous tubules.
 
Interactions
Pum1 interacts with 307 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adult locomotory behavior, cell differentiation, ...
Component cytoplasm, cytoplasmic mRNA processing body, ...
Function mRNA 3'-UTR binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (54)    Tissues (44)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
RT-PCR 19
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pum1    NEW 
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009596 (Evidence)
Ensembl Gene Model ENSMUSG00000028580 (Evidence)
Entrez Gene 80912 (Evidence)
DFCI TC1587643, TC1572028, TC1622633
DoTS DT.91568231, DT.490697, DT.101124898, DT.91414918, DT.102536860
NIA Mouse Gene Index U004886
Consensus CDS Project CCDS18710.1, CCDS51311.1, CCDS51312.1, CCDS51313.1, CCDS51314.1
International Mouse Phenotyping Consortium Status Pum1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009596 VEGA Gene Model | MGI Sequence Detail 118244 C57BL/6J ±  kb
transcript OTTMUST00000022038 VEGA | MGI Sequence Detail 5389 Not Applicable 
polypeptide OTTMUSP00000010040 VEGA | MGI Sequence Detail 1189 Not Applicable 

For the selected sequences
All sequences(171) RefSeq(110) UniProt(9)
Polymorphisms
SNPs within 2kb(404 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR001313 Pumilio RNA-binding repeat
Protein Ontology PR:000013492 pumilio homolog 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:221497 Gennarino VA, et al., Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell. 2015 Mar 12;160(6):1087-98
All references(47)
Other
accession IDs
MGI:2140159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory