Pum1 MGI Mouse Gene Detail - MGI:1931749 - pumilio RNA-binding family member 1

Pum1 Gene Detail

Symbol

Pum1
Name

pumilio RNA-binding family member 1
Synonyms

mKIAA0099, Pumm

Feature Type

protein coding gene
IDs

MGI:1931749
NCBI Gene: 80912
Gene Overview

MyGene.info: PUM1

Sequence Map

Chr4:130663321-130781564 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

118244 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.43 cM
Mapping Data

2 experiments

Human Ortholog

PUM1, pumilio RNA binding family member 1

Vertebrate Orthologs

10

Human Ortholog

PUM1, pumilio RNA binding family member 1
Orthology source: HomoloGene, HGNC
Synonyms

HSPUM, PUMH, PUMH1, PUML1
Links

HGNC:14957

NCBI Gene ID: 9698

neXtProt AC: NX_Q14671

UniProt: Q14671
Chr Location

1p35.2; chr1:30931506-31065717 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 22830
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PUM1
Gene Tree

Pum1

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Phenotype Summary

10 phenotypes from 3 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

319
Chemically induced (other)

2
Gene trapped

310
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Pum1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

162 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased testes weight and size, decreased body weight, oligozoospermia, reduced male fertility, increased male germ cell apoptosis and small seminiferous tubules.

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All GO Annotations

24
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

54
Tissues

44
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pum1

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Pum1 interacts with 307 markers (Mir1b, Mir9-1, Mir9-2, ...) View All

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All Sequences

126
RefSeq

74
UniProt

9
CCDS

CCDS18710.1, CCDS51311.1, CCDS51312.1, CCDS51313.1, CCDS51314.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000009596	VEGA Gene Model \| MGI Sequence Detail	118244	C57BL/6J	± kb
transcript	OTTMUST00000022038	VEGA \| MGI Sequence Detail	5389	Not Applicable
polypeptide	OTTMUSP00000010040	VEGA \| MGI Sequence Detail	1189	Not Applicable

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SNPs within 2kb

404 from dbSNP Build 142

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UniProt

9 Sequences
Protein Ontology

PR:000013492 pumilio homolog 1

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR033133 Pumilio homology domain

IPR033712 Pumilio, RNA binding domain

IPR001313 Pumilio RNA-binding repeat

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All nucleic 19

cDNA 16

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2140159

Summaries

All 51

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 20
Earliest

J:23094 Davisson MT, New chromosome aberrations. Mouse News Lett. 1988;80:166
Latest

J:236329 Mak W, et al., An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biol Reprod. 2016 Jun;94(6):134

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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