About   Help   FAQ
Pum1
Gene Detail
 Symbol
Name
ID
Pum1
pumilio RNA-binding family member 1
MGI:1931749
Synonyms mKIAA0099, Pumm
Feature Type protein coding gene
Genetic Map
Chromosome 4
63.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:130663321-130781564 bp, + strand
From VEGA annotation of GRCm38

  118244 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pum1

Human
homologs
Human Homolog PUM1, pumilio RNA-binding family member 1
NCBI Gene ID 9698
neXtProt AC  NX_Q14671
Human Synonyms  HSPUM, PUMH, PUMH1, PUML1
Human Chr (Location)  1p35.2; chr1:30931506-31065717 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(315) : Gene trapped(310) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased testes weight and size, decreased body weight, oligozoospermia, reduced male fertility, increased male germ cell apoptosis and small seminiferous tubules.
 
Interactions
Pum1 interacts with 308 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process regulation of translation
Component cytoplasm
Function poly(A) RNA binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (54)    Tissues (40)    Images (21)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 35
RT-PCR 19
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009596 (Evidence)
Ensembl Gene ModelENSMUSG00000028580 (Evidence)
Entrez Gene80912 (Evidence)
DFCITC1572028, TC1587643, TC1622633
DoTSDT.101124898, DT.102536860, DT.490697, DT.91414918, DT.91568231
NIA Mouse Gene IndexU004886
Consensus CDS ProjectCCDS18710.1, CCDS51311.1, CCDS51312.1, CCDS51313.1, CCDS51314.1
International Mouse Knockout Project StatusPum1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009596 VEGA Gene Model | MGI Sequence Detail 118244 C57BL/6J ±  kb
transcript OTTMUST00000022038 VEGA | MGI Sequence Detail 5389 Not Applicable 
polypeptide OTTMUSP00000010040 VEGA | MGI Sequence Detail 1189 Not Applicable 

For the selected sequences
All sequences(167) RefSeq(106) UniProt(9)
Polymorphisms SNPs within 2kb(404 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR001313 Pumilio RNA-binding repeat
Protein Ontology PR:000013492 pumilio homolog 1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:201814 Kotani T, et al., Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules. J Cell Biol. 2013 Sep 30;202(7):1041-55
All references(47)
Other
accession IDs
MGI:2140159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory