Pum1
Gene Detail

Symbol Name ID

Pum1 pumilio RNA-binding family member 1 MGI:1931749

Synonyms

mKIAA0099, Pumm

Feature Type

protein coding gene

Genetic Map

Chromosome 4

63.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:130663321-130781564 bp, + strand From VEGA annotation of GRCm38   118244 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pum1

Human homologs

Human Homolog		PUM1, pumilio RNA-binding family member 1
NCBI Gene ID		9698
neXtProt AC		NX_Q14671
Human Synonyms		HSPUM, PUMH, PUMH1, PUML1
Human Chr (Location)		1p35.2; chr1:30931506-31065717 (-)  GRCh38

Alleles and phenotypes

All alleles(315) : Gene trapped(310) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit decreased testes weight and size, decreased body weight, oligozoospermia, reduced male fertility, increased male germ cell apoptosis and small seminiferous tubules.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	regulation of translation
Component	cytoplasm
Function	poly(A) RNA binding, RNA binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (54)    Tissues (40)    Images (21)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	35
RT-PCR	19

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000009596 (Evidence)
Ensembl Gene Model	ENSMUSG00000028580 (Evidence)
Entrez Gene	80912 (Evidence)
DFCI	TC1572028, TC1587643, TC1622633
DoTS	DT.101124898, DT.102536860, DT.490697, DT.91414918, DT.91568231
NIA Mouse Gene Index	U004886
Consensus CDS Project	CCDS18710.1, CCDS51311.1, CCDS51312.1, CCDS51313.1, CCDS51314.1
International Mouse Knockout Project Status	Pum1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009596	VEGA Gene Model | MGI Sequence Detail	118244	C57BL/6J
transcript	OTTMUST00000022038	VEGA | MGI Sequence Detail	5389	Not Applicable
polypeptide	OTTMUSP00000010040	VEGA | MGI Sequence Detail	1189	Not Applicable

All sequences(167) RefSeq(106) UniProt(9)

Polymorphisms

SNPs within 2kb(404 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR001313	Pumilio RNA-binding repeat
Protein Ontology	PR:000013492	pumilio homolog 1

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:201814 Kotani T, et al., Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules. J Cell Biol. 2013 Sep 30;202(7):1041-55
All references(47)

Other accession IDs

MGI:2140159