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Pum1 Gene Detail
Summary
  • Symbol
    Pum1
  • Name
    pumilio RNA-binding family member 1
  • Synonyms
    mKIAA0099, Pumm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931749
    NCBI Gene: 80912
  • Gene Overview
    MyGene.info: PUM1
Location & Maps
more
  • Sequence Map
    Chr4:130663321-130781564 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118244 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PUM1, pumilio RNA binding family member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PUM1, pumilio RNA binding family member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPUM, PUMH, PUMH1, PUML1
  • Links
    NCBI Gene ID: 9698
    neXtProt AC: NX_Q14671

  • Chr Location
    1p35.2; chr1:30931506-31065717 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 22830
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PUM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    319
  • Chemically induced (other)
    2
  • Gene trapped
    310
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Pum1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased testes weight and size, decreased body weight, oligozoospermia, reduced male fertility, increased male germ cell apoptosis and small seminiferous tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009596 VEGA Gene Model | MGI Sequence Detail 118244 C57BL/6J ±  kb
transcript OTTMUST00000022038 VEGA | MGI Sequence Detail 5389 Not Applicable  
polypeptide OTTMUSP00000010040 VEGA | MGI Sequence Detail 1189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    404 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 19
    cDNA 16
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140159
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:226959 Zhang C, et al., Loss of preimplantation embryo resulting from a Pum1 gene trap mutation. Biochem Biophys Res Commun. 2015 Jun 19;462(1):8-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory