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March7 Gene Detail
Summary
  • Symbol
    March7
  • Name
    membrane-associated ring finger (C3HC4) 7
  • Synonyms
    Axot, Gtrgeo17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931053
    NCBI Gene: 57438
  • Gene Overview
    MyGene.info: MARCH7
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:60209936-60248385 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 34.46 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931053
protein coding gene Chr2:60209887-60250676 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025759
protein coding gene Chr2:59790662-59832123 (+)
A/J MGP_AJ_G0025735
protein coding gene Chr2:57484832-57525986 (+)
AKR/J MGP_AKRJ_G0025705
protein coding gene Chr2:59053374-59097063 (+)
BALB/cJ MGP_BALBcJ_G0025730
protein coding gene Chr2:57588741-57629877 (+)
C3H/HeJ MGP_C3HHeJ_G0025491
protein coding gene Chr2:59168683-59209477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026177
protein coding gene Chr2:61553076-61595277 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023581
protein coding gene Chr2:55088585-55110243 (+)
CAST/EiJ MGP_CASTEiJ_G0024955
protein coding gene Chr2:59207664-59249784 (+)
CBA/J MGP_CBAJ_G0025471
protein coding gene Chr2:63896368-63937092 (+)
DBA/2J MGP_DBA2J_G0025602
protein coding gene Chr2:57087485-57129099 (+)
FVB/NJ MGP_FVBNJ_G0025564
protein coding gene Chr2:56636794-56677781 (+)
LP/J MGP_LPJ_G0025690
protein coding gene Chr2:59642737-59683458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025595
protein coding gene Chr2:65508783-65551227 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026234
protein coding gene Chr2:59090111-59132239 (+)
PWK/PhJ MGP_PWKPhJ_G0024696
protein coding gene Chr2:56938230-56982929 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024503
protein coding gene Chr2:59161356-59200047 (+)
WSB/EiJ MGP_WSBEiJ_G0025023
protein coding gene Chr2:59385799-59427418 (+)



Homology
more
  • Human Ortholog
    MARCH7, membrane associated ring-CH-type finger 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MARCH7, membrane associated ring-CH-type finger 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AXO, AXOT, MARCH-VII, RNF177
  • Links
    NCBI Gene ID: 64844
    neXtProt AC: NX_Q9H992
    UniProt: Q9H992

  • Chr Location
    2q24.2; chr2:159712457-159768583 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10753
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MARCH7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show premature neural degeneration and defective development of the corpus callosum. Both T cell proliferation and T cell-derived leukaemia inhibitory factor are increased.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57438 NCBI Gene Model | MGI Sequence Detail 38450 C57BL/6J ±  kb
    transcript NM_020575 RefSeq | MGI Sequence Detail 2719 C57BL/6  
    polypeptide Q9WV66 UniProt | EBI | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 216
      cDNA 215
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:894656
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory