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March7
Gene Detail
Symbol

Name
ID
March7
membrane-associated ring finger (C3HC4) 7
MGI:1931053
Synonyms
Axot, Gtrgeo17
Feature Type
protein coding gene
Genetic Map
Chromosome 2
34.46 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:60209887-60250676 bp, + strand
From VEGA annotation of GRCm38

  40790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: March7

Human
homologs
Human Homolog MARCH7, membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
NCBI Gene ID 64844
neXtProt AC  NX_Q9H992
Human Synonyms  AXO, AXOT, MARCH-VII, RNF177
Human Chr (Location)  2q24.2; chr2:159712457-159768583 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(66) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show premature neural degeneration and defective development of the corpus callosum. Both T cell proliferation and T cell-derived leukaemia inhibitory factor are increased.
 
Interactions
March7 interacts with 272 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 2
cDNA source data(214)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(215) cDNA(214) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000012814 (Evidence)
Ensembl Gene ModelENSMUSG00000026977 (Evidence)
Entrez Gene57438 (Evidence)
UniGene260635
DFCITC1574977, TC1602163, TC1609490, TC1662657
DoTSDT.101128883, DT.101388319, DT.40164519, DT.494796, DT.91338336, DT.94276006, DT.94409785
NIA Mouse Gene IndexU001805
EC6.3.2.-
Consensus CDS ProjectCCDS16057.1
International Mouse Knockout Project StatusMarch7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012814 VEGA Gene Model | MGI Sequence Detail 40790 C57BL/6J ±  kb
transcript OTTMUST00000030733 VEGA | MGI Sequence Detail 2271 Not Applicable 
polypeptide OTTMUSP00000013782 VEGA | MGI Sequence Detail 693 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011016 Zinc finger, RING-CH-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000010181 E3 ubiquitin-protein ligase MARCH7
References
(Earliest) J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:894656

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory