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March7 Gene Detail
Summary
  • Symbol
    March7
  • Name
    membrane-associated ring finger (C3HC4) 7
  • Synonyms
    Axot, Gtrgeo17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931053
    NCBI Gene: 57438
  • Gene Overview
    MyGene.info: MARCH7
Location & Maps
more
  • Sequence Map
    Chr2:60209887-60250676 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40790 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 34.46 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MARCH7, membrane associated ring-CH-type finger 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MARCH7, membrane associated ring-CH-type finger 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AXO, AXOT, MARCH-VII, RNF177
  • Links
    NCBI Gene ID: 64844
    neXtProt AC: NX_Q9H992

  • Chr Location
    2q24.2; chr2:159712457-159768583 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    73
  • Chemically induced (other)
    1
  • Gene trapped
    66
  • Targeted
    6
  • Genomic Mutations
    1 involving March7
  • Incidental Mutations
Homozygous null mice show premature neural degeneration and defective development of the corpus callosum. Both T cell proliferation and T cell-derived leukaemia inhibitory factor are increased.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012814 VEGA Gene Model | MGI Sequence Detail 40790 C57BL/6J ±  kb
transcript OTTMUST00000030731 VEGA | MGI Sequence Detail 3594 Not Applicable  
polypeptide OTTMUSP00000013781 VEGA | MGI Sequence Detail 693 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    128 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010181 E3 ubiquitin-protein ligase MARCH7
  • EC
  • InterPro Domains
    IPR011016 Zinc finger, RING-CH-type
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 215
    cDNA 214
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
less
MGI:894656
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory