Clcnkb
Gene Detail

Symbol Name ID

Clcnkb chloride channel Kb MGI:1930643

Synonyms

Clck2, Clcnk1l

Feature Type

protein coding gene

Genetic Map

Chromosome 4

74.02 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:141404353-141416014 bp, - strand From VEGA annotation of GRCm38   11662 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:107317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: chloride channel protein ClC-K
Gene Tree: Clcnkb

Human homologs

Human Homolog		CLCNKA, chloride channel, voltage-sensitive Ka
NCBI Gene ID		1187
neXtProt AC		NX_P51800
Human Synonyms		ClC-K1, CLCK1, hClC-Ka
Human Chr (Location)		1p36; chr1:16348486-16360545 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CLCNKA

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	chloride transport, ion transport, ...
Component	chloride channel complex, integral to membrane, ...
Function	chloride channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000010299 (Evidence)
Ensembl Gene Model	ENSMUSG00000006216 (Evidence)
Entrez Gene	56365 (Evidence)
DFCI	TC1587394, TC1643243, TC1666182, TC1676990
DoTS	DT.101208271, DT.487923, DT.60104123, DT.91338723, DT.94133008, DT.97396721
NIA Mouse Gene Index	U025724, U242046
Consensus CDS Project	CCDS18872.1
International Mouse Knockout Project Status	Clcnkb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010299	VEGA Gene Model | MGI Sequence Detail	11662	C57BL/6J
transcript	OTTMUST00000023973	VEGA | MGI Sequence Detail	2370	Not Applicable
polypeptide	OTTMUSP00000010991	VEGA | MGI Sequence Detail	687	Not Applicable

All sequences(43) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002250	Chloride channel ClC-K
InterPro	IPR014743	Chloride channel, core
InterPro	IPR001807	Chloride channel, voltage gated
InterPro	IPR000644	Cystathionine beta-synthase, core
Protein Ontology	PR:000005536	chloride channel protein ClC-Kb

References

(Earliest) J:114790 Estevez R, et al., Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion. Nature. 2001 Nov 29;414(6863):558-61
(Latest) J:173125 Pietila I, et al., Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol. 2011 May 1;353(1):50-60
All references(29)