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Clcnkb
Gene Detail
Symbol

Name
ID
Clcnkb
chloride channel Kb
MGI:1930643
Synonyms
Clck2, Clcnk1l
Feature Type
protein coding gene
Genetic Map
Chromosome 4
74.02 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:141404353-141416014 bp, - strand
From VEGA annotation of GRCm38

  11662 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:107317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: CLCNKA
Protein SuperFamily: chloride channel protein ClC-K
Gene Tree: Clcnkb

Human
homologs
CLCNKA, chloride channel, voltage-sensitive Ka
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1187
neXtProt AC: NX_P51800

Human Synonyms: ClC-K1, CLCK1, hClC-Ka

Human Chr (Location): 1p36; chr1:16021991-16034050 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CLCNKA

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Clcnkb (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Clcnkb interacts with 83 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process chloride transmembrane transport, chloride transport, ...
Component chloride channel complex, integral component of membrane, ...
Function chloride channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (49)    Tissues (49)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487225    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000010299 (Evidence)
Ensembl Gene Model ENSMUSG00000006216 (Evidence)
Entrez Gene 56365 (Evidence)
DFCI TC1676990, TC1666182, TC1643243, TC1587394
DoTS DT.101208271, DT.487923, DT.97396721, DT.94133008, DT.60104123, DT.91338723
NIA Mouse Gene Index U242046, U025724
Consensus CDS Project CCDS18872.1
International Mouse Phenotyping Consortium Status Clcnkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010299 VEGA Gene Model | MGI Sequence Detail 11662 C57BL/6J ±  kb
transcript OTTMUST00000023973 VEGA | MGI Sequence Detail 2370 Not Applicable 
polypeptide OTTMUSP00000010991 VEGA | MGI Sequence Detail 687 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002250 Chloride channel ClC-K
InterPro IPR014743 Chloride channel, core
InterPro IPR001807 Chloride channel, voltage gated
InterPro IPR000644 Cystathionine beta-synthase, core
Protein Ontology PR:000005536 chloride channel protein ClC-Kb
References
(Earliest) J:114790 Estevez R, et al., Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion. Nature. 2001 Nov 29;414(6863):558-61
(Latest) J:195944 Arnaiz I, et al., Changing expression of chloride channels during preimplantation mouse development. Reproduction. 2013 Jan;145(1):73-84
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory