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Trpm7 Gene Detail
Summary
  • Symbol
    Trpm7
  • Name
    transient receptor potential cation channel, subfamily M, member 7
  • Synonyms
    2310022G15Rik, 4833414K03Rik, 5033407O22Rik, CHAK, CHAK1, Ltpr7, LTRPC7, TRP-PLIK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929996
    NCBI Gene: 58800
  • Gene Overview
    MyGene.info: TRPM7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:126791565-126876230 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84666 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TRPM7, transient receptor potential cation channel subfamily M member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM7, transient receptor potential cation channel subfamily M member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALSPDC, CHAK, CHAK1, LTrpC-7, LTRPC7, TRP-PLIK
  • Links
    NCBI Gene ID: 54822
    neXtProt AC: NX_Q96QT4
    UniProt: Q96QT4

  • Chr Location
    15q21.2; chr15:50557158-50686835 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lehality. Mice with conditional deletion in developing thymocytes display a block in thymopoiesis. Mice homozygous for a kinase deleted allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit altered magnesium homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015961 VEGA Gene Model | MGI Sequence Detail 84666 C57BL/6J ±  kb
    transcript OTTMUST00000037942 VEGA | MGI Sequence Detail 7107 Not Applicable  
    polypeptide OTTMUSP00000017028 VEGA | MGI Sequence Detail 1863 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      323 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1921848, MGI:1923209, MGI:1924250
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:262737 Beesetty P, et al., Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry. Sci Rep. 2018 Feb 14;8(1):3023

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory