Trpm7
Gene Detail

Symbol Name ID

Trpm7 transient receptor potential cation channel, subfamily M, member 7 MGI:1929996

Synonyms

2310022G15Rik, 4833414K03Rik, 5033407O22Rik, CHAK, CHAK1, Ltpr7, LTRPC7, TRP-PLIK

Feature Type

protein coding gene

Genetic Map

Chromosome 2

61.76 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:126791565-126876230 bp, - strand From VEGA annotation of GRCm38   84666 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channels TRPM6/TRPM7
Gene Tree: Trpm7

Human homologs

Human Homolog		TRPM7, transient receptor potential cation channel, subfamily M, member 7
NCBI Gene ID		54822
neXtProt AC		NX_Q96QT4
Human Synonyms		ALSPDC, CHAK, CHAK1, LTRPC7, TRP-PLIK
Human Chr (Location)		15q21; chr15:50849351-50979012 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRPM7

Alleles and phenotypes

All alleles(16) : Targeted(5) Gene trapped(11)
 

Mice homozygous for a null allele display embryonic lehality. Mice with conditional deletion in developing thymocytes display a block in thymopoiesis.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	actomyosin structure organization, calcium-dependent cell-matrix adhesion, ...
Component	cytoplasm, integral to membrane, ...
Function	actin binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (34)    Tissues (12)    Images (8)
Theiler Stages: 20, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	6
RT-PCR	28

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015961 (Evidence)
Ensembl Gene Model	ENSMUSG00000027365 (Evidence)
Entrez Gene	58800 (Evidence)
DFCI	TC1573029
DoTS	DT.101738217, DT.110743233, DT.491501, DT.94348799
NIA Mouse Gene Index	U023309
EC	2.7.11.1
PDB	1IAH, 1IAJ, 1IA9
Consensus CDS Project	CCDS16689.1, CCDS50700.1
International Mouse Knockout Project Status	Trpm7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015961	VEGA Gene Model | MGI Sequence Detail	84666	C57BL/6J
transcript	OTTMUST00000037942	VEGA | MGI Sequence Detail	7107	Not Applicable
polypeptide	OTTMUSP00000017028	VEGA | MGI Sequence Detail	1863	Not Applicable

All sequences(63) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(248 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR004166	MHCK/EF2 kinase
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000016703	transient receptor potential cation channel subfamily M member 7

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185090 Guinamard R, et al., A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney. Biochim Biophys Acta. 2012 May;1818(5):1135-41
All references(52)

Other accession IDs

MGI:1921848, MGI:1923209, MGI:1924250