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Trpm7
Gene Detail
 Symbol
Name
ID
Trpm7
transient receptor potential cation channel, subfamily M, member 7
MGI:1929996
Synonyms 2310022G15Rik, 4833414K03Rik, 5033407O22Rik, CHAK, CHAK1, Ltpr7, LTRPC7, TRP-PLIK
Feature Type protein coding gene
Genetic Map
Chromosome 2
61.76 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:126791565-126876230 bp, - strand
From VEGA annotation of GRCm38

  84666 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channels TRPM6/TRPM7
Gene Tree: Trpm7

Human
homologs
Human Homolog TRPM7, transient receptor potential cation channel, subfamily M, member 7
NCBI Gene ID 54822
neXtProt AC  NX_Q96QT4
Human Synonyms  ALSPDC, CHAK, CHAK1, LTrpC-7, LTRPC7, TRP-PLIK
Human Chr (Location)  15q21; chr15:50557154-50686815 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRPM7
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(11) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lehality. Mice with conditional deletion in developing thymocytes display a block in thymopoiesis. Mice homozygous for a kinase deleted allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit altered magnesium homeostasis.
 
Interactions
Trpm7 interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process actomyosin structure organization, calcium-dependent cell-matrix adhesion, ...
Component cytoplasm, integral component of membrane, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (34)    Tissues (12)    Images (8)
Theiler Stages: 20, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 6
RT-PCR 28
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015961 (Evidence)
Ensembl Gene ModelENSMUSG00000027365 (Evidence)
Entrez Gene58800 (Evidence)
DFCITC1573029
DoTSDT.101738217, DT.110743233, DT.491501, DT.94348799
NIA Mouse Gene IndexU023309
EC2.7.11.1
PDB1IAH, 1IAJ, 1IA9
Consensus CDS ProjectCCDS16689.1, CCDS50700.1
International Mouse Knockout Project StatusTrpm7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015961 VEGA Gene Model | MGI Sequence Detail 84666 C57BL/6J ±  kb
transcript OTTMUST00000037942 VEGA | MGI Sequence Detail 7107 Not Applicable 
polypeptide OTTMUSP00000017028 VEGA | MGI Sequence Detail 1863 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(328 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR004166 MHCK/EF2 kinase
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000016703 transient receptor potential cation channel subfamily M member 7
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208282 Cai Z, et al., Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol. 2014 Jan;16(1):55-65
All references(56)
Other
accession IDs
MGI:1921848, MGI:1923209, MGI:1924250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory