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Rsad2 Gene Detail
Summary
  • Symbol
    Rsad2
  • Name
    radical S-adenosyl methionine domain containing 2
  • Synonyms
    2510004L01Rik, cig5, Vig1, viperin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929628
    NCBI Gene: 58185
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:26442746-26456452 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 9.69 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929628
protein coding gene Chr12:26442743-26456452 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019637
protein coding gene Chr12:24177170-24190854 (-)
A/J MGP_AJ_G0019604
protein coding gene Chr12:23546600-23560317 (-)
AKR/J MGP_AKRJ_G0019575
protein coding gene Chr12:24304194-24317811 (-)
BALB/cJ MGP_BALBcJ_G0019581
protein coding gene Chr12:23781400-23795113 (-)
C3H/HeJ MGP_C3HHeJ_G0019385
protein coding gene Chr12:24195227-24208939 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017609
protein coding gene Chr10:51989113-51998682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017653
protein coding gene Chr12:22978085-22991635 (-)
CAST/EiJ MGP_CASTEiJ_G0018940
protein coding gene Chr12:19174792-19188518 (-)
CBA/J MGP_CBAJ_G0019356
protein coding gene Chr12:25749240-25762950 (-)
DBA/2J MGP_DBA2J_G0019470
protein coding gene Chr12:23360100-23373713 (-)
FVB/NJ MGP_FVBNJ_G0019461
protein coding gene Chr12:23233807-23247516 (-)
LP/J MGP_LPJ_G0019540
protein coding gene Chr12:24244916-24258627 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019496
protein coding gene Chr12:25526183-25539927 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020068
protein coding gene Chr12:23859009-23872722 (-)
PWK/PhJ MGP_PWKPhJ_G0018707
protein coding gene Chr12:18113630-18127841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018495
protein coding gene Chr12:18361377-18375012 (-)
WSB/EiJ MGP_WSBEiJ_G0018991
protein coding gene Chr12:24048750-24062366 (-)



Homology
more
  • Human Ortholog
    RSAD2, radical S-adenosyl methionine domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RSAD2, radical S-adenosyl methionine domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2510004L01Rik, cig33, cig5, vig1
  • Links
    NCBI Gene ID: 91543
    neXtProt AC: NX_Q8WXG1
    UniProt: Q8WXG1

  • Chr Location
    2p25.2; chr2:6865733-6898239 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10969
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RSAD2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired T-helper 2 differentitation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020641 Ensembl Gene Model | MGI Sequence Detail 13707 C57BL/6J ±  kb
transcript ENSMUST00000020970 Ensembl | MGI Sequence Detail 3782 Not Applicable  
polypeptide ENSMUSP00000020970 Ensembl | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    cDNA 86

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919695
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:66317 Boudinot P, et al., vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family. J Virol. 1999 Mar;73(3):1846-52
  • Latest
    J:270961 Van der Hoek KH, et al., Viperin is an important host restriction factor in control of Zika virus infection. Sci Rep. 2017 Jun 30;7(1):4475

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory