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Rsad2
Gene Detail
 Symbol
Name
ID
Rsad2
radical S-adenosyl methionine domain containing 2
MGI:1929628
Synonyms 2510004L01Rik, cig5, Vig1, viperin
Feature Type protein coding gene
Genetic Map
Chromosome 12
9.69 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:26442753-26456452 bp, - strand
From VEGA annotation of GRCm38

  13700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rsad2

Human
homologs
Human Homolog RSAD2, radical S-adenosyl methionine domain containing 2
NCBI Gene ID 91543
neXtProt AC  NX_Q8WXG1
Human Synonyms  2510004L01Rik, cig33, cig5, vig1
Human Chr (Location)  2p25.2; chr2:6877665-6898232 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit impaired T-helper 2 differentitation.
 
Interactions
Rsad2 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process CD4-positive, alpha-beta T cell activation, CD4-positive, alpha-beta T cell differentiation, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function 4 iron, 4 sulfur cluster binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(85)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) cDNA(85)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027569 (Evidence)
Ensembl Gene ModelENSMUSG00000020641 (Evidence)
Entrez Gene58185 (Evidence)
DFCITC1573798, TC1644965, TC1692484
DoTSDT.101130489, DT.101406615, DT.101406617, DT.110926396, DT.110926428, DT.487691, DT.99866452
NIA Mouse Gene IndexU033851
Consensus CDS ProjectCCDS25848.1
International Mouse Knockout Project StatusRsad2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027569 VEGA Gene Model | MGI Sequence Detail 13700 C57BL/6J ±  kb
transcript OTTMUST00000068265 VEGA | MGI Sequence Detail 3775 Not Applicable 
polypeptide OTTMUSP00000034468 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(275 from dbSNP Build 137)    SNPs within 2kb including multiple locations(279)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR026372 Antiviral radical SAM protein viperin
InterPro IPR006638 Elongator protein 3/MiaB/NifB
InterPro IPR007197 Radical SAM
Protein Ontology PR:000014318 radical S-adenosyl methionine domain-containing protein 2
References (Earliest) J:66317 Boudinot P, et al., vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family. J Virol. 1999 Mar;73(3):1846-52
(Latest) J:193971 Teng TS, et al., Viperin restricts chikungunya virus replication and pathology. J Clin Invest. 2012 Dec 3;122(12):4447-60
All references(42)
Other
accession IDs
MGI:1919695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory