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Ascl3 Gene Detail
Summary
  • Symbol
    Ascl3
  • Name
    achaete-scute family bHLH transcription factor 3
  • Synonyms
    bHLHa42, ICRFP703B1614Q5.4, ICRFP703N2430Q5.4, Sgn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928820
    NCBI Gene: 56787
Location & Maps
more
  • Sequence Map
    Chr7:109727465-109731726 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4262 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.46 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ASCL3, achaete-scute family bHLH transcription factor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ASCL3, achaete-scute family bHLH transcription factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHa42, HASH3, SGN1
  • Links
    NCBI Gene ID: 56676
    neXtProt AC: NX_Q9NQ33

  • Chr Location
    11p15.3; chr11:8937572-8943033 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    14 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ascl3
  • Incidental Mutations
    APF
Mice heterozygous for a null allele are born at the expected frequency and exhibit normal growth, fertility, survival and salivary gland function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060127 VEGA Gene Model | MGI Sequence Detail 4262 C57BL/6J ±  kb
transcript OTTMUST00000147179 VEGA | MGI Sequence Detail 700 Not Applicable  
polypeptide OTTMUSP00000076606 VEGA | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    49 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004364 achaete-scute homolog 3
  • InterPro Domains
    IPR015660 Achaete-scute transcription factor-related
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 10
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:71643 Cichutek A, et al., Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). Cytogenet Cell Genet. 2001;93(3-4):277-83
  • Latest
    J:173845 Arany S, et al., Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration. Dev Biol. 2011 May 15;353(2):186-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory