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Ascl3 Gene Detail
Summary
  • Symbol
    Ascl3
  • Name
    achaete-scute family bHLH transcription factor 3
  • Synonyms
    bHLHa42, ICRFP703B1614Q5.4, ICRFP703N2430Q5.4, Sgn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928820
    NCBI Gene: 56787
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109727465-109731726 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928820
protein coding gene Chr7:109727465-109731732 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032846
protein coding gene Chr7:113170601-113174820 (-)
A/J MGP_AJ_G0032830
protein coding gene Chr7:110371942-110376232 (-)
AKR/J MGP_AKRJ_G0032761
protein coding gene Chr7:113146481-113150755 (-)
BALB/cJ MGP_BALBcJ_G0032834
protein coding gene Chr7:110071538-110075650 (-)
C3H/HeJ MGP_C3HHeJ_G0032544
protein coding gene Chr7:113175691-113179902 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033340
protein coding gene Chr7:117861210-117865316 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030313
protein coding gene Chr7:111941184-111945363 (-)
CAST/EiJ MGP_CASTEiJ_G0031872
protein coding gene Chr7:104702866-104706848 (-)
CBA/J MGP_CBAJ_G0032517
protein coding gene Chr7:121732241-121739085 (-)
DBA/2J MGP_DBA2J_G0032669
protein coding gene Chr7:108483068-108487536 (-)
FVB/NJ MGP_FVBNJ_G0032622
protein coding gene Chr7:108332731-108336914 (-)
LP/J MGP_LPJ_G0032763
protein coding gene Chr7:114698708-114706679 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032654
protein coding gene Chr7:123383705-123384363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033361
protein coding gene Chr7:112155963-112160073 (-)
PWK/PhJ MGP_PWKPhJ_G0031579
protein coding gene Chr7:101283214-101287585 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031427
protein coding gene Chr7:98842532-98846947 (-)
WSB/EiJ MGP_WSBEiJ_G0031985
protein coding gene Chr7:112993365-112998175 (-)



Homology
more
  • Human Ortholog
    ASCL3, achaete-scute family bHLH transcription factor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ASCL3, achaete-scute family bHLH transcription factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHa42, HASH3, SGN1
  • Links
    NCBI Gene ID: 56676
    neXtProt AC: NX_Q9NQ33
    UniProt: Q9NQ33

  • Chr Location
    11p15.4; chr11:8937572-8943033 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    16 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ascl3
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
  • Recombinase Activity
Mice heterozygous for a null allele are born at the expected frequency and exhibit normal growth, fertility, survival and salivary gland function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035951 Ensembl Gene Model | MGI Sequence Detail 4262 C57BL/6J ±  kb
transcript ENSMUST00000035372 Ensembl | MGI Sequence Detail 700 Not Applicable  
polypeptide ENSMUSP00000037702 Ensembl | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 11
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:265300 Montoro DT, et al., A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018 Aug;560(7718):319-324

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory