Dpys
Gene Detail

Symbol Name ID

Dpys dihydropyrimidinase MGI:1928679

Synonyms

1200017I10Rik, 1300004I01Rik, DHPase

Feature Type

protein coding gene

Genetic Map

Chromosome 15

15.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:39768485-39857470 bp, - strand From VEGA annotation of GRCm38   88986 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dpys

Human homologs

Human Homolog		DPYS, dihydropyrimidinase
NCBI Gene ID		1807
neXtProt AC		NX_Q14117
Human Synonyms		DHP, DHPase
Human Chr (Location)		8q22; chr8:105391652-105479277 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DPYS

Alleles and phenotypes

All alleles(38) : Targeted(2) Gene trapped(36)

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	beta-alanine metabolic process, metabolic process, ...
Component	cytoplasm, cytosol
Function	amino acid binding, dihydropyrimidinase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033243 (Evidence)
Ensembl Gene Model	ENSMUSG00000022304 (Evidence)
Entrez Gene	64705 (Evidence)
UniGene	275974
DFCI	TC1583458, TC1593243
DoTS	DT.40169049, DT.530774
NIA Mouse Gene Index	U036124
EC	3.5.2.2
Consensus CDS Project	CCDS27445.1
International Mouse Knockout Project Status	Dpys

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033243	VEGA Gene Model | MGI Sequence Detail	88986	C57BL/6J
transcript	OTTMUST00000083312	VEGA | MGI Sequence Detail	2468	Not Applicable
polypeptide	OTTMUSP00000044737	VEGA | MGI Sequence Detail	519	Not Applicable

All sequences(35) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(755 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006680	Amidohydrolase 1
InterPro	IPR011778	Hydantoinase/dihydropyrimidinase
InterPro	IPR011059	Metal-dependent hydrolase, composite domain
Protein Ontology	PR:000006679	dihydropyrimidinase

References

(Earliest) J:172925 Kikugawa M, et al., Purification, characterization and inhibition of dihydropyrimidinase from rat liver. Eur J Biochem. 1994 Jan 15;219(1-2):393-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Other accession IDs

MGI:1921091, MGI:1924152