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Dpys
Gene Detail
Symbol

Name
ID
Dpys
dihydropyrimidinase
MGI:1928679
Synonyms
1200017I10Rik, 1300004I01Rik, DHPase
Feature Type
protein coding gene
Genetic Map
Chromosome 15
15.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:39768485-39857470 bp, - strand
From VEGA annotation of GRCm38

  88986 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DPYS
Gene Tree: Dpys

Human
homologs
DPYS, dihydropyrimidinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1807
neXtProt AC: NX_Q14117

Human Synonyms: DHP, DHPase

Human Chr (Location): 8q22; chr8:104379424-104467049 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DPYS

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(36) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Dpys interacts with 168 markers (Mir7-1, Mir17, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process beta-alanine metabolic process, protein homooligomerization, ...
Component cytoplasm, cytosol, ...
Function amino acid binding, dihydropyrimidinase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DPYS ; Xenbase dpys    NEW 
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033243 (Evidence)
Ensembl Gene Model ENSMUSG00000022304 (Evidence)
Entrez Gene 64705 (Evidence)
UniGene 275974
DFCI TC1593243, TC1583458
DoTS DT.40169049, DT.530774
NIA Mouse Gene Index U036124
EC 3.5.2.2
Consensus CDS Project CCDS27445.1
International Mouse Phenotyping Consortium Status Dpys
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033243 VEGA Gene Model | MGI Sequence Detail 88986 C57BL/6J ±  kb
transcript OTTMUST00000083312 VEGA | MGI Sequence Detail 2468 Not Applicable 
polypeptide OTTMUSP00000044737 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1088 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase 1
InterPro IPR011778 Hydantoinase/dihydropyrimidinase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000006679 dihydropyrimidinase
References
(Earliest) J:172925 Kikugawa M, et al., Purification, characterization and inhibition of dihydropyrimidinase from rat liver. Eur J Biochem. 1994 Jan 15;219(1-2):393-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:1921091, MGI:1924152

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory