Stk3
Gene Detail

Symbol Name ID

Stk3 serine/threonine kinase 3 MGI:1928487

Synonyms

0610042I06Rik, mess1, MST, Mst2, Ste20

Feature Type

protein coding gene

Genetic Map

Chromosome 15

14.34 cM, cytoband B3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:34875496-35155806 bp, - strand From VEGA annotation of GRCm38   280311 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Stk3

Human homologs

Human Homolog		STK3, serine/threonine kinase 3
NCBI Gene ID		6788
neXtProt AC		NX_Q13188
Human Synonyms		KRS1, MST2
Human Chr (Location)		8q22.2; chr8:99466859-99954799 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(7) Gene trapped(7)
 

Homozygous inactivation of this gene generally results in mice that are viable, fertile and developmentally normal. A small subset of mice homozygous for a knock-out allele develop mammary tumors in the absence of immunological defects.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	apoptotic process, cell differentiation involved in embryonic placenta development, ...
Component	cytoplasm, nucleus
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000032792 (Evidence)
Ensembl Gene Model	ENSMUSG00000022329 (Evidence)
Entrez Gene	56274 (Evidence)
UniGene	262330
DFCI	TC1580910, TC1586073, TC1590624, TC1695800, TC1708067
DoTS	DT.103588940, DT.40141788
NIA Mouse Gene Index	U036082
EC	2.7.11.1
Consensus CDS Project	CCDS37059.1
International Mouse Knockout Project Status	Stk3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032792	VEGA Gene Model | MGI Sequence Detail	280311	C57BL/6J
transcript	OTTMUST00000081660	VEGA | MGI Sequence Detail	2914	Not Applicable
polypeptide	OTTMUSP00000043714	VEGA | MGI Sequence Detail	497	Not Applicable

All sequences(43) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1004 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024205	Mst1 SARAH domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR011524	SARAH domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology	PR:000015746	serine/threonine-protein kinase 3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195266 Reginensi A, et al., Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
All references(50)

Other accession IDs

MGI:1914102