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Stk3
Gene Detail
Symbol

Name
ID
Stk3
serine/threonine kinase 3
MGI:1928487
Synonyms
0610042I06Rik, mess1, MST, Mst2, Ste20
Feature Type
protein coding gene
Genetic Map
Chromosome 15
14.34 cM, cytoband B3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:34875496-35155806 bp, - strand
From VEGA annotation of GRCm38

  280311 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STK3
Gene Tree: Stk3

Human
homologs
STK3, serine/threonine kinase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6788
neXtProt AC: NX_Q13188

Human Synonyms: KRS1, MST2

Human Chr (Location): 8q22.2; chr8:98371355-98942571 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(7) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene generally results in mice that are viable, fertile and developmentally normal. A small subset of mice homozygous for a knock-out allele develop mammary tumors in the absence of immunological defects.
 
Interactions
Stk3 interacts with 247 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process activation of MAPKK activity, apoptotic process, ...
Component cytoplasm, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stk3 ; ZFIN stk3    NEW 
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000032792 (Evidence)
Ensembl Gene Model ENSMUSG00000022329 (Evidence)
Entrez Gene 56274 (Evidence)
UniGene 262330
DFCI TC1586073, TC1580910, TC1695800, TC1590624, TC1708067
DoTS DT.40141788, DT.103588940
NIA Mouse Gene Index U036082
EC 2.7.11.1
Consensus CDS Project CCDS37059.1
International Mouse Phenotyping Consortium Status Stk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032792 VEGA Gene Model | MGI Sequence Detail 280311 C57BL/6J ±  kb
transcript OTTMUST00000081660 VEGA | MGI Sequence Detail 2914 Not Applicable 
polypeptide OTTMUSP00000043714 VEGA | MGI Sequence Detail 497 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(1709 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024205 Mst1 SARAH domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR011524 SARAH domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000015746 serine/threonine-protein kinase 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214531 Du X, et al., Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS One. 2014;9(3):e90701
All references(53)
Other
accession IDs
MGI:1914102

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory