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Ptges
Gene Detail
Symbol

Name
ID
Ptges
prostaglandin E synthase
MGI:1927593
Synonyms
2410099E23Rik, D2Ertd369e, mPGES, mPGES-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:30889471-30929863 bp, - strand
From VEGA annotation of GRCm38

  40393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3587  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTGES
Protein SuperFamily: glutathione-dependent prostaglandin E synthase
Gene Tree: Ptges

Human
homologs
PTGES, prostaglandin E synthase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9536
neXtProt AC: NX_O14684

Human Synonyms: MGST1L1, MGST1-L1, MGST-IV, MPGES, mPGES-1, PGES, PIG12, PP102, PP1294, TP53I12

Human Chr (Location): 9q34.3; chr9:129738336-129777327 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(17) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are fertile and display a decreased inflammatory response. Mice homozygous for a conditional allele activated in the vascular smooth muscle, endothelial or myeloid cells exhibit altered response to vascular injury.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Ptges interacts with 243 markers (Mir18, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component cytoplasm, integral component of membrane, ...
Function glutathione binding, isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (154)    Tissues (113)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 140
RT-PCR 7
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptges    NEW 
Molecular
reagents
All nucleic(55) cDNA(53) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000011878 (Evidence)
Ensembl Gene Model ENSMUSG00000050737 (Evidence)
Entrez Gene 64292 (Evidence)
UniGene 28768
DFCI TC1704262, TC1577897
DoTS DT.533334, DT.87049607
NIA Mouse Gene Index U022483
EC 5.3.99.3
Consensus CDS Project CCDS15889.1
International Mouse Phenotyping Consortium Status Ptges
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011878 VEGA Gene Model | MGI Sequence Detail 40393 C57BL/6J ±  kb
transcript OTTMUST00000028002 VEGA | MGI Sequence Detail 3647 Not Applicable 
polypeptide OTTMUSP00000012699 VEGA | MGI Sequence Detail 153 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(97 from dbSNP Build 137)    SNPs within 2kb including multiple locations(103)
Protein-related
information
ResourceIDDescription
InterPro IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain
InterPro IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Protein Ontology PR:000013421 prostaglandin E synthase
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:219009 Kovarova M, et al., PGE(2) promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells. PLoS One. 2014;9(7):e102948
All references(103)
Other
accession IDs
MGI:1196242, MGI:1920952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory