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Ptges
Gene Detail
Symbol

Name
ID
Ptges
prostaglandin E synthase
MGI:1927593
Synonyms
2410099E23Rik, D2Ertd369e, mPGES, mPGES-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:30889471-30929863 bp, - strand
From VEGA annotation of GRCm38

  40393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3587  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutathione-dependent prostaglandin E synthase
Gene Tree: Ptges

Human
homologs
Human Homolog PTGES, prostaglandin E synthase
NCBI Gene ID 9536
neXtProt AC  NX_O14684
Human Synonyms  MGST1L1, MGST1-L1, MGST-IV, MPGES, mPGES-1, PGES, PIG12, PP102, PP1294, TP53I12
Human Chr (Location)  9q34.3; chr9:129738336-129753065 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(32) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are fertile and display a decreased inflammatory response. Mice homozygous for a conditional allele activated in the vascular smooth muscle, endothelial or myeloid cells exhibit altered response to vascular injury.
 
Interactions
Ptges interacts with 243 markers (Mir18, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component cytoplasm, integral component of membrane, ...
Function glutathione binding, isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (154)    Tissues (113)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 140
RT-PCR 7
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(53) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011878 (Evidence)
Ensembl Gene ModelENSMUSG00000050737 (Evidence)
Entrez Gene64292 (Evidence)
UniGene28768
DFCITC1577897, TC1704262
DoTSDT.87049607, DT.533334
NIA Mouse Gene IndexU022483
EC5.3.99.3
Consensus CDS ProjectCCDS15889.1
International Mouse Knockout Project StatusPtges
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011878 VEGA Gene Model | MGI Sequence Detail 40393 C57BL/6J ±  kb
transcript OTTMUST00000028002 VEGA | MGI Sequence Detail 3647 Not Applicable 
polypeptide OTTMUSP00000012699 VEGA | MGI Sequence Detail 153 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(97 from dbSNP Build 137)    SNPs within 2kb including multiple locations(103)
Protein-related
information
ResourceIDDescription
InterPro IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain
InterPro IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Protein Ontology PR:000013421 prostaglandin E synthase
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:211086 Chen L, et al., Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proc Natl Acad Sci U S A. 2014 May 6;111(18):6828-33
All references(102)
Other
accession IDs
MGI:1196242, MGI:1920952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory