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Xrcc2 Gene Detail
Summary
  • Symbol
    Xrcc2
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 2
  • Synonyms
    4921524O04Rik, 8030409M04Rik, RecA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927345
    NCBI Gene: 57434
  • Gene Overview
    MyGene.info: XRCC2
Location & Maps
more
  • Sequence Map
    Chr5:25689812-25705825 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16014 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    XRCC2, X-ray repair complementing defective repair in Chinese hamster cells 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    XRCC2, X-ray repair complementing defective repair in Chinese hamster cells 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 7516
    neXtProt AC: NX_O43543

  • Chr Location
    7q36.1; chr7:152646498-152676165 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3964
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: XRCC2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    5 involving Xrcc2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit chromosomal instability, excess neuronal apoptosis, and lethality ranging from midgestation through birth. Neonates die from respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024269 VEGA Gene Model | MGI Sequence Detail 16014 C57BL/6J ±  kb
transcript OTTMUST00000059416 VEGA | MGI Sequence Detail 3247 Not Applicable  
polypeptide OTTMUSP00000028897 VEGA | MGI Sequence Detail 278 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    182 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017505 DNA repair protein XRCC2
  • InterPro Domains
    IPR013632 DNA recombination and repair protein Rad51, C-terminal
    IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    IPR030547 DNA repair protein XRCC2
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 36
    cDNA 35
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1918160, MGI:1925986
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 9
    Phenotypes 27
  • Earliest
    J:48438 Cartwright R, et al., The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/ RAD51 family. Nucleic Acids Res. 1998 Jul 1;26(13):3084-9
  • Latest
    J:211631 Lee Y, et al., Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss. J Neurosci. 2014 Jun 4;34(23):7836-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory