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Xrcc2
Gene Detail
 Symbol
Name
ID
Xrcc2
X-ray repair complementing defective repair in Chinese hamster cells 2
MGI:1927345
Synonyms 4921524O04Rik, 8030409M04Rik, RecA
Feature Type protein coding gene
Genetic Map
Chromosome 5
12.35 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:25689812-25705825 bp, - strand
From VEGA annotation of GRCm38

  16014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Xrcc2

Human
homologs
Human Homolog XRCC2, X-ray repair complementing defective repair in Chinese hamster cells 2
NCBI Gene ID 7516
neXtProt AC  NX_O43543
Human Chr (Location)  7q36.1; chr7:152646498-152676165 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit chromosomal instability, excess neuronal apoptosis, and lethality ranging from midgestation through birth. Neonates die from respiratory failure.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular response to DNA damage stimulus, centrosome organization, ...
Component centrosome, nucleus, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (1)   
Theiler Stages: 23
Assay TypeResults
RT-PCR 3
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024269 (Evidence)
Ensembl Gene ModelENSMUSG00000028933 (Evidence)
Entrez Gene57434 (Evidence)
UniGene143767
DFCITC1581254, TC1600958
DoTSDT.101365015, DT.91317542, DT.97345208
NIA Mouse Gene IndexU026017
Consensus CDS ProjectCCDS19135.1
International Mouse Knockout Project StatusXrcc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024269 VEGA Gene Model | MGI Sequence Detail 16014 C57BL/6J ±  kb
transcript OTTMUST00000059416 VEGA | MGI Sequence Detail 3247 Not Applicable 
polypeptide OTTMUSP00000028897 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(182 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR020588 DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000017505 DNA repair protein XRCC2
References (Earliest) J:48438 Cartwright R, et al., The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/ RAD51 family. Nucleic Acids Res. 1998 Jul 1;26(13):3084-9
(Latest) J:193481 Barlow JH, et al., Identification of Early Replicating Fragile Sites that Contribute to Genome Instability. Cell. 2013 Jan 31;152(3):620-32
All references(43)
Other
accession IDs
MGI:1918160, MGI:1925986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory