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Nrgn
Gene Detail
Symbol

Name
ID
Nrgn
neurogranin
MGI:1927184
Synonyms
0710001B06Rik, NG, NG/RC3, protein kinase C substrate, Pss1, RC3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
20.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:37544492-37552904 bp, - strand
From VEGA annotation of GRCm38

  8413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136026  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle

HCOP human homology predictions: NRGN
Gene Tree: Nrgn

Human
homologs
NRGN, neurogranin (protein kinase C substrate, RC3)
Orthology source: HGNC

IDs:
NCBI Gene ID: 4900
neXtProt AC: NX_Q92686

Human Synonyms: hng, RC3

Human Chr (Location): 11q24; chr11:124739933-124747206 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 
Homozygotes for a targeted null mutation exhibit impaired spatial learning and altered hippocampal short- and long-term plasticity. Heterozygotes show milder effects.
 
Interactions
Nrgn interacts with 129 markers (Mir20a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process intracellular signal transduction, nervous system development, ...
Component axon, cell junction, ...
Function calmodulin binding, phosphatidic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (81)    Tissues (44)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 44
Northern blot 12
RT-PCR 21
cDNA source data(81)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) cDNA(83) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000043307 (Evidence)
Ensembl Gene Model ENSMUSG00000053310 (Evidence)
Entrez Gene 64011 (Evidence)
UniGene 335065
DFCI TC1575729
DoTS DT.492376, DT.97354017
NIA Mouse Gene Index U030689
PDB 4E50
Consensus CDS Project CCDS40585.1
International Mouse Phenotyping Consortium Status Nrgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043307 VEGA Gene Model | MGI Sequence Detail 8413 C57BL/6J ±  kb
transcript OTTMUST00000113604 VEGA | MGI Sequence Detail 1453 Not Applicable 
polypeptide OTTMUSP00000063504 VEGA | MGI Sequence Detail 78 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
Protein Ontology PR:000011426 neurogranin
References
(Earliest) J:16935 Danielson PE, et al., Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Genomics. 1994 Feb;19(3):454-61
(Latest) J:203255 Huang FL, et al., Methylphenidate improves the behavioral and cognitive deficits of neurogranin knockout mice. Genes Brain Behav. 2012 Oct;11(7):794-805
All references(56)
Other
accession IDs
MGD-MRK-16623, MGI:1915658, MGI:2143128, MGI:2143450, MGI:99834

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory