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Nrgn
Gene Detail
 Symbol
Name
ID
Nrgn
neurogranin
MGI:1927184
Synonyms 0710001B06Rik, NG, NG/RC3, protein kinase C substrate, Pss1, RC3
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:37544492-37552904 bp, - strand
From VEGA annotation of GRCm38

  8413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136026  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle

Gene Tree: Nrgn

Alleles
and
phenotypes
All alleles(3) : Gene trapped(1) Targeted(2)
 
Homozygotes for a targeted null mutation exhibit impaired spatial learning and altered hippocampal short- and long-term plasticity. Heterozygotes show milder effects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process intracellular signal transduction
Component cell junction, cell projection, ...
Function calmodulin binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (17)    Tissues (4)    Images (4)
Theiler Stages: 24, 28
Assay TypeResults
Immunohistochemistry 4
Northern blot 12
RT-PCR 1
cDNA source data(81)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(83) cDNA(82) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043307 (Evidence)
Ensembl Gene ModelENSMUSG00000053310 (Evidence)
Entrez Gene64011 (Evidence)
UniGene335065
DFCITC1575729
DoTSDT.492376, DT.97354017
NIA Mouse Gene IndexU030689
PDB4E50
Consensus CDS ProjectCCDS40585.1
International Mouse Knockout Project StatusNrgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043307 VEGA Gene Model | MGI Sequence Detail 8413 C57BL/6J ±  kb
transcript OTTMUST00000113604 VEGA | MGI Sequence Detail 1453 Not Applicable 
polypeptide OTTMUSP00000063504 VEGA | MGI Sequence Detail 78 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
Protein Ontology PR:000011426 neurogranin
References (Earliest) J:16935 Danielson PE, et al., Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Genomics. 1994 Feb;19(3):454-61
(Latest) J:203255 Huang FL, et al., Methylphenidate improves the behavioral and cognitive deficits of neurogranin knockout mice. Genes Brain Behav. 2012 Oct;11(7):794-805
All references(56)
Other
accession IDs
MGD-MRK-16623, MGI:1915658, MGI:2143128, MGI:2143450, MGI:99834

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory