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Nrgn Gene Detail
Summary
  • Symbol
    Nrgn
  • Name
    neurogranin
  • Synonyms
    0710001B06Rik, NG, NG/RC3, protein kinase C substrate, Pss1, RC3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927184
    NCBI Gene: 64011
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37455789-37464041 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.78 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927184
 protein coding gene Chr9:37455788-37464200 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034568
 protein coding gene Chr9:35543310-35551680 (-)
A/J MGP_AJ_G0034547
 protein coding gene Chr9:34589060-34597515 (-)
AKR/J MGP_AKRJ_G0034474
 protein coding gene Chr9:35347467-35355831 (-)
BALB/cJ MGP_BALBcJ_G0034538
 protein coding gene Chr9:34426695-34435078 (-)
C3H/HeJ MGP_C3HHeJ_G0034251
 protein coding gene Chr9:35780478-35788865 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035060
 protein coding gene Chr9:36679161-36687551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031986
 protein coding gene Chr9:33692712-33701344 (-)
CAST/EiJ MGP_CASTEiJ_G0033572
 protein coding gene Chr9:35475393-35485263 (-)
CBA/J MGP_CBAJ_G0034224
 protein coding gene Chr9:37941863-37950224 (-)
DBA/2J MGP_DBA2J_G0034382
 protein coding gene Chr9:34636436-34644944 (-)
FVB/NJ MGP_FVBNJ_G0034323
 protein coding gene Chr9:33888385-33896757 (-)
LP/J MGP_LPJ_G0034467
 protein coding gene Chr9:35719754-35728152 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034369
 protein coding gene Chr9:39540054-39549196 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035079
 protein coding gene Chr9:35286278-35294667 (-)
PWK/PhJ MGP_PWKPhJ_G0033278
 protein coding gene Chr9:34532498-34541072 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033112
 protein coding gene Chr9:35482771-35491132 (-)
WSB/EiJ MGP_WSBEiJ_G0033688
 protein coding gene Chr9:35103565-35111949 (-)



Homology
more
  • Human Ortholog
    NRGN, neurogranin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRGN, neurogranin
  • Synonyms
    hng, RC3
  • Links
    NCBI Gene ID: 4900
    neXtProt AC: NX_Q92686
    UniProt: Q92686

  • Chr Location
    11q24.2; chr11:124739942-124747210 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired spatial learning and altered hippocampal short- and long-term plasticity. Heterozygotes show milder effects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    58
  • cDNA Data
    85
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64011 NCBI Gene Model | MGI Sequence Detail 8253 C57BL/6J ±  kb
    transcript NM_022029 RefSeq | MGI Sequence Detail 1293 ZRU/MplStud  
    polypeptide P60761 UniProt | EBI | MGI Sequence Detail 78 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 91
      cDNA 87
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16623, MGI:1915658, MGI:2143128, MGI:2143450, MGI:99834
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 26
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:16935 Danielson PE, et al., Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Genomics. 1994 Feb;19(3):454-61
    • Latest
      J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory