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Postn Gene Detail
Summary
  • Symbol
    Postn
  • Name
    periostin, osteoblast specific factor
  • Synonyms
    A630052E07Rik, Osf2, OSF-2, peri, Periostin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926321
    NCBI Gene: 50706
Location & Maps
more
  • Sequence Map
    Chr3:54361109-54391037 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29929 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    POSTN, periostin, osteoblast specific factor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    POSTN, periostin, osteoblast specific factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OSF2, OSF-2, PDLPOSTN, PN
  • Links
    NCBI Gene ID: 10631
    neXtProt AC: NX_Q15063

  • Chr Location
    13q13.3; chr13:37562582-37598844 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Postn mouse models

Human Disease Mouse Models
       Periodontitis, Aggressive, 2   OMIM: 608526 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Postn
  • Incidental Mutations
Homozygous null mice display abnormalities of the enamel, periodontal ligament, ameloblasts, and incisors. For one allele changing the hardness of the food alters the severity of the abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029043 VEGA Gene Model | MGI Sequence Detail 29929 C57BL/6J ±  kb
transcript OTTMUST00000072064 VEGA | MGI Sequence Detail 2670 Not Applicable  
polypeptide OTTMUSP00000037010 VEGA | MGI Sequence Detail 838 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    249 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 270
    cDNA 263
    Primer pair 5
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139789, MGI:2444610
References
more
  • Summaries
    All 139
    Developmental Gene Expression 70
    Diseases 2
    Gene Ontology 9
    Phenotypes 49
  • Earliest
    J:61606 Takeshita S, et al., Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993 Aug 15;294(Pt 1):271-8
  • Latest
    J:227080 Taylor SH, et al., Matrix metalloproteinase 14 is required for fibrous tissue expansion. Elife. 2015;4:e09345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory