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Postn
Gene Detail
Symbol

Name
ID
Postn
periostin, osteoblast specific factor
MGI:1926321
Synonyms
A630052E07Rik, Osf2, OSF-2, peri, Periostin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
25.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:54361109-54391034 bp, + strand
From VEGA annotation of GRCm38

  29926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Gene Tree: Postn

Human
homologs
Human Homolog   POSTN, periostin, osteoblast specific factor
NCBI Gene ID 10631
neXtProt AC  NX_Q15063
Human Synonyms  OSF2, OSF-2, PDLPOSTN, periostin, PN
Human Chr (Location)  13q13.3; chr13:37562582-37598844 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display abnormalities of the enamel, periodontal ligament, ameloblasts, and incisors. For one allele changing the hardness of the food alters the severity of the abnormalities.
 
Human Diseases Modeled in Mice Using Postn (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Postn interacts with 167 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, extracellular matrix organization, ...
Component extracellular matrix, extracellular region, ...
Function cell adhesion molecule binding, heparin binding
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (109)    Tissues (83)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 23
RNA in situ 76
RT-PCR 10
cDNA source data(262)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(267) cDNA(263) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029043 (Evidence)
Ensembl Gene ModelENSMUSG00000027750 (Evidence)
Entrez Gene50706 (Evidence)
UniGene236067
DFCITC1635960, TC1593236, TC1588489, TC1573347
DoTSDT.101291106, DT.101125134, DT.101333039, DT.534163
NIA Mouse Gene IndexU003236
Consensus CDS ProjectCCDS17351.1, CCDS57211.1, CCDS57212.1
International Mouse Knockout Project StatusPostn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029043 VEGA Gene Model | MGI Sequence Detail 29926 C57BL/6J ±  kb
transcript OTTMUST00000072064 VEGA | MGI Sequence Detail 2670 Not Applicable 
polypeptide OTTMUSP00000037010 VEGA | MGI Sequence Detail 838 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(12) UniProt(6)
Polymorphisms
SNPs within 2kb(249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011489 EMI domain
InterPro IPR000782 FAS1 domain
InterPro IPR016666 TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Protein Ontology PR:000013031 periostin
References
(Earliest) J:61606 Takeshita S, et al., Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993 Aug 15;294(Pt 1):271-8
(Latest) J:217173 Lockhart MM, et al., Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014 Dec 1;396(1):8-18
All references(133)
Disease annotation references (1)
Other
accession IDs
MGI:2139789, MGI:2444610

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory