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Postn Gene Detail
Summary
  • Symbol
    Postn
  • Name
    periostin, osteoblast specific factor
  • Synonyms
    A630052E07Rik, Osf2, OSF-2, peri, Periostin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926321
    NCBI Gene: 50706
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:54268530-54298458 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 25.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    863 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926321
 protein coding gene Chr3:54266688-54298462 (+)
129S1/SvImJ ENSMUSG00200022729
 protein coding gene Chr3:51120222-51150152 (+)
A/J ENSMUSG00195029841
 protein coding gene Chr3:51056757-51086687 (+)
AKR/J ENSMUSG00220028465
 protein coding gene Chr3:51115592-51145513 (+)
BALB/cJ ENSMUSG00180022500
 protein coding gene Chr3:51136493-51166411 (+)
C3H/HeJ ENSMUSG00175008738
 protein coding gene Chr3:50976269-51006181 (+)
C57BL/6NJ ENSMUSG00215008068
 protein coding gene Chr3:51414802-51444732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024989
 protein coding gene Chr3:47937376-47966416 (+)
CAST/EiJ ENSTCUG00005009325
 protein coding gene Chr3:50783539-50813464 (+)
CBA/J ENSMUSG00210003416
 protein coding gene Chr3:51097663-51127577 (+)
DBA/2J ENSMUSG00185026593
 protein coding gene Chr3:51316261-51346193 (+)
FVB/NJ ENSMUSG00205009191
 protein coding gene Chr3:50295003-50324937 (+)
JF1/MsJ ENSUMUG00000023341
 protein coding gene Chr3:50739753-50769714 (+)
LP/J ENSMUSG00230003204
 protein coding gene Chr3:53274889-53304817 (+)
NOD/ShiLtJ ENSMUSG00190030175
 protein coding gene Chr3:51450842-51480758 (+)
NZO/HlLtJ ENSMUSG00225015703
 protein coding gene Chr3:55887288-55917216 (+)
PWK/PhJ ENSLUMG00010009617
 protein coding gene Chr3:50860965-50890894 (+)
SPRET/EiJ ENSMSPG00010007327
 protein coding gene Chr3:51608552-51638331 (+)
WSB/EiJ ENSIUOG00005008870
 protein coding gene Chr3:51254740-51284686 (+)



Homology
more
  • Human Ortholog
    POSTN, periostin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POSTN, periostin
  • Synonyms
    OSF-2, OSF2, PDLPOSTN, PN
  • Links
    NCBI Gene ID: 10631
    UniProt: Q15063

  • Chr Location
    13q13.3; chr13:37562582-37598855 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Postn mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 5 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    155 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormalities of the enamel, periodontal ligament, ameloblasts, and incisors. For one allele changing the hardness of the food alters the severity of the abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1386
  • Tissues
    421
  • cDNA Data
    267
  • Literature Summary
    129
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027750 Ensembl Gene Model | MGI Sequence Detail 29929 C57BL/6J ±  kb
    transcript ENSMUST00000081564 Ensembl | MGI Sequence Detail 2670 Not Applicable  
    polypeptide ENSMUSP00000080276 Ensembl | MGI Sequence Detail 838 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 297
      cDNA 268
      Primer pair 23
      Other 6
      Antibodies 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139789, MGI:2444610
    References
    more
    • Summaries
      All 368
      Developmental Gene Expression 129
      Diseases 3
      Gene Ontology 19
      Phenotypes 155
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory