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Postn
Gene Detail
Symbol

Name
ID
Postn
periostin, osteoblast specific factor
MGI:1926321
Synonyms
A630052E07Rik, Osf2, OSF-2, peri, Periostin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
25.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:54361109-54391034 bp, + strand
From VEGA annotation of GRCm38

  29926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: POSTN
Protein SuperFamily: TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Gene Tree: Postn

Human
homologs
POSTN, periostin, osteoblast specific factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10631
neXtProt AC: NX_Q15063

Human Synonyms: OSF2, OSF-2, PDLPOSTN, periostin, PN

Human Chr (Location): 13q13.3; chr13:37562582-37598844 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display abnormalities of the enamel, periodontal ligament, ameloblasts, and incisors. For one allele changing the hardness of the food alters the severity of the abnormalities.
 
Human Diseases Modeled in Mice Using Postn (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Postn interacts with 166 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell adhesion, extracellular matrix organization, ...
Component cytoplasm, extracellular matrix, ...
Function cell adhesion molecule binding, heparin binding
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (192)    Tissues (115)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 35
RNA in situ 104
Northern blot 6
Western blot 22
RT-PCR 25
cDNA source data(262)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA POSTN ; Xenbase postn ; ZFIN postna, postnb    NEW 
Molecular
reagents
All nucleic(270) cDNA(263) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029043 (Evidence)
Ensembl Gene Model ENSMUSG00000027750 (Evidence)
Entrez Gene 50706 (Evidence)
UniGene 236067
DFCI TC1573347, TC1588489, TC1593236, TC1635960
DoTS DT.101125134, DT.101291106, DT.101333039, DT.534163
NIA Mouse Gene Index U003236
Consensus CDS Project CCDS17351.1, CCDS57211.1, CCDS57212.1
International Mouse Phenotyping Consortium Status Postn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029043 VEGA Gene Model | MGI Sequence Detail 29926 C57BL/6J ±  kb
transcript OTTMUST00000072064 VEGA | MGI Sequence Detail 2670 Not Applicable 
polypeptide OTTMUSP00000037010 VEGA | MGI Sequence Detail 838 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(12) UniProt(6)
Polymorphisms
SNPs within 2kb(249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011489 EMI domain
InterPro IPR000782 FAS1 domain
InterPro IPR016666 TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Protein Ontology PR:000013031 periostin
References
(Earliest) J:61606 Takeshita S, et al., Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993 Aug 15;294(Pt 1):271-8
(Latest) J:221511 Smid JK, et al., Periostin induces pancreatic regeneration. Endocrinology. 2015 Mar;156(3):824-36
All references(139)
Disease annotation references (1)
Other
accession IDs
MGI:2139789, MGI:2444610

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory