Postn
Gene Detail

Symbol Name ID

Postn periostin, osteoblast specific factor MGI:1926321

Synonyms

A630052E07Rik, Osf2, OSF-2, peri, Periostin

Feature Type

protein coding gene

Genetic Map

Chromosome 3

25.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:54361109-54391034 bp, + strand From VEGA annotation of GRCm38   29926 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Gene Tree: Postn

Human homologs

Human Homolog		POSTN, periostin, osteoblast specific factor
NCBI Gene ID		10631
neXtProt AC		NX_Q15063
Human Synonyms		OSF2, OSF-2, PDLPOSTN, periostin, PN, RP11-412K4.1
Human Chr (Location)		13q13.3; chr13:38136719-38172981 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous null mice display abnormalities of the enamel, periodontal ligament, ameloblasts, and incisors. For one allele changing the hardness of the food alters the severity of the abnormalities.

 
Human Diseases Modeled Using Mouse Postn (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cell adhesion, extracellular matrix organization, ...
Component	extracellular matrix, extracellular region, ...
Function	heparin binding

External Resources: FuncBase

Expression

Literature Summary: (53 records)
Data Summary: Results (97)    Tissues (75)    Images (22)
Theiler Stages: 10, 14, 15, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	11
RNA in situ	76
RT-PCR	10

cDNA source data(263)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(268) cDNA(264) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029043 (Evidence)
Ensembl Gene Model	ENSMUSG00000027750 (Evidence)
Entrez Gene	50706 (Evidence)
UniGene	236067
DFCI	TC1573347, TC1588489, TC1593236, TC1635960
DoTS	DT.101125134, DT.101291106, DT.101333039, DT.534163
NIA Mouse Gene Index	U003236
Consensus CDS Project	CCDS17351.1, CCDS57211.1, CCDS57212.1
International Mouse Knockout Project Status	Postn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029043	VEGA Gene Model | MGI Sequence Detail	29926	C57BL/6J
transcript	OTTMUST00000072064	VEGA | MGI Sequence Detail	2670	Not Applicable
polypeptide	OTTMUSP00000037010	VEGA | MGI Sequence Detail	838	Not Applicable

All sequences(65) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(224 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011489	EMI domain
InterPro	IPR000782	FAS1 domain
InterPro	IPR016666	TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Protein Ontology	PR:000013031	periostin

References

(Earliest) J:61606 Takeshita S, et al., Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993 Aug 15;294(Pt 1):271-8
(Latest) J:192176 Casanova JC, et al., Epithelial-to-mesenchymal transition in epicardium is independent of snail1. Genesis. 2013 Jan;51(1):32-40
All references(110)

Other accession IDs

MGI:2139789, MGI:2444610