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Ltn1 Gene Detail
Summary
  • Symbol
    Ltn1
  • Name
    listerin E3 ubiquitin protein ligase 1
  • Synonyms
    4930528H02Rik, Listerin, Rnf160, Zfp294
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926163
    NCBI Gene: 78913
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87376651-87432612 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 49.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926163
protein coding gene Chr16:87376651-87432620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022976
protein coding gene Chr16:88086008-88148256 (-)
A/J MGP_AJ_G0022944
protein coding gene Chr16:84028843-84084976 (-)
AKR/J MGP_AKRJ_G0022914
protein coding gene Chr16:86574049-86639311 (-)
BALB/cJ MGP_BALBcJ_G0022946
protein coding gene Chr16:84554645-84611448 (-)
C3H/HeJ MGP_C3HHeJ_G0022708
protein coding gene Chr16:87137594-87201959 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023393
protein coding gene Chr16:90948569-91015823 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020897
protein coding gene Chr16:81882272-81937536 (-)
CAST/EiJ MGP_CASTEiJ_G0022230
protein coding gene Chr16:87521087-87578435 (-)
CBA/J MGP_CBAJ_G0022677
protein coding gene Chr16:94851899-94916425 (-)
DBA/2J MGP_DBA2J_G0022811
protein coding gene Chr16:83951424-84008041 (-)
FVB/NJ MGP_FVBNJ_G0022786
protein coding gene Chr16:83053135-83115437 (-)
LP/J MGP_LPJ_G0022880
protein coding gene Chr16:87779226-87836910 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022805
protein coding gene Chr16:99405993-99470428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023411
protein coding gene Chr16:87041079-87106374 (-)
PWK/PhJ MGP_PWKPhJ_G0021973
protein coding gene Chr16:84069480-84117810 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021803
protein coding gene Chr16:86573457-86636531 (-)
WSB/EiJ MGP_WSBEiJ_G0022278
protein coding gene Chr16:87281301-87349086 (-)



Homology
more
  • Human Ortholog
    LTN1, listerin E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LTN1, listerin E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21orf10, C21orf98, RNF160, ZNF294
  • Links
    NCBI Gene ID: 26046
    neXtProt AC: NX_O94822
    UniProt: O94822

  • Chr Location
    21q21.3; chr21:28928144-28992959 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32272
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LTN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    4 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display embryonic lethality. Mice homozygous for a point mutation display progressive neuron degeneration and age dependent motor deficits.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052299 Ensembl Gene Model | MGI Sequence Detail 55962 C57BL/6J ±  kb
    transcript ENSMUST00000039449 Ensembl | MGI Sequence Detail 7743 Not Applicable  
    polypeptide ENSMUSP00000038775 Ensembl | MGI Sequence Detail 1767 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 131
      Primer pair 1
      Other 1

      Microarray probesets 27
    Other
    Accession IDs
    less
    MGI:2146604, MGI:2146728
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory