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Vps33a Gene Detail
Summary
  • Symbol
    Vps33a
  • Name
    VPS33A CORVET/HOPS core subunit
  • Synonyms
    3830421M04Rik, bf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924823
    NCBI Gene: 77573
  • Gene Overview
    MyGene.info: VPS33A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123528659-123573038 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.03 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924823
protein coding gene Chr5:123527304-123573043 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030075
protein coding gene Chr5:127267569-127312660 (-)
A/J MGP_AJ_G0030040
protein coding gene Chr5:121992512-122028167 (-)
AKR/J MGP_AKRJ_G0029976
protein coding gene Chr5:125932611-125963393 (-)
BALB/cJ MGP_BALBcJ_G0030051
protein coding gene Chr5:123325706-123359293 (-)
C3H/HeJ MGP_C3HHeJ_G0029768
protein coding gene Chr5:126540916-126571401 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030504
protein coding gene Chr5:132203555-132245434 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027730
protein coding gene Chr5:116539681-116565122 (-)
CAST/EiJ MGP_CASTEiJ_G0029177
protein coding gene Chr5:125637444-125668925 (-)
CBA/J MGP_CBAJ_G0029738
protein coding gene Chr5:137398455-137433199 (-)
DBA/2J MGP_DBA2J_G0029888
protein coding gene Chr5:122010784-122040280 (-)
FVB/NJ MGP_FVBNJ_G0029844
protein coding gene Chr5:121038325-121082470 (-)
LP/J MGP_LPJ_G0029977
protein coding gene Chr5:127810811-127850426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029875
protein coding gene Chr5:141034607-141066277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030545
protein coding gene Chr5:125517513-125559519 (-)
PWK/PhJ MGP_PWKPhJ_G0028891
protein coding gene Chr5:120815205-120861591 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028728
protein coding gene Chr5:123197320-123227884 (-)
WSB/EiJ MGP_WSBEiJ_G0029252
protein coding gene Chr5:126189367-126236763 (-)



Homology
more
  • Human Ortholog
    VPS33A, VPS33A, CORVET/HOPS core subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS33A, VPS33A, CORVET/HOPS core subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MPSPS
  • Links
    NCBI Gene ID: 65082
    neXtProt AC: NX_Q96AX1
    UniProt: Q96AX1

  • Chr Location
    12q24.31; chr12:122231547-122266521 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Vps33a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene produce hypopigmentation, an extended bleeeding time and abnormal kidney function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029434 Ensembl Gene Model | MGI Sequence Detail 44380 C57BL/6J ±  kb
    transcript ENSMUST00000031388 Ensembl | MGI Sequence Detail 4235 Not Applicable  
    polypeptide ENSMUSP00000031388 Ensembl | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1541, MGI:2140920, MGI:2141131, MGI:2141231, MGI:88148
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236240 Hubert V, et al., LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes. Biol Open. 2016 Oct 15;5(10):1516-1529

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory