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Nkrf Gene Detail
Summary
  • Symbol
    Nkrf
  • Name
    NF-kappaB repressing factor
  • Synonyms
    9430034D17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924536
    NCBI Gene: 77286
  • Gene Overview
    MyGene.info: NKRF
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:36887540-36902899 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 21.30 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924536
protein coding gene ChrX:36886440-36903344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035627
protein coding gene ChrX:31823312-31838665 (-)
A/J MGP_AJ_G0035604
protein coding gene ChrX:31879101-31895838 (-)
AKR/J MGP_AKRJ_G0035537
protein coding gene ChrX:32600796-32617749 (-)
BALB/cJ MGP_BALBcJ_G0035597
protein coding gene ChrX:31620013-31635377 (-)
C3H/HeJ MGP_C3HHeJ_G0035315
protein coding gene ChrX:32137760-32153594 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036133
protein coding gene ChrX:32458775-32474141 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032995
protein coding gene ChrX:30108458-30123560 (-)
CAST/EiJ MGP_CASTEiJ_G0034605
protein coding gene ChrX:20291492-20308462 (-)
CBA/J MGP_CBAJ_G0035284
protein coding gene ChrX:33307877-33323235 (-)
DBA/2J MGP_DBA2J_G0035435
protein coding gene ChrX:31707946-31723463 (-)
FVB/NJ MGP_FVBNJ_G0035382
protein coding gene ChrX:31479643-31495221 (-)
LP/J MGP_LPJ_G0035517
protein coding gene ChrX:32170856-32188127 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035426
protein coding gene ChrX:33768861-33785116 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036140
protein coding gene ChrX:31787478-31802843 (-)
PWK/PhJ MGP_PWKPhJ_G0034307
protein coding gene ChrX:19755735-19771147 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034148
protein coding gene ChrX:20778825-20794096 (-)
WSB/EiJ MGP_WSBEiJ_G0034741
protein coding gene ChrX:31588147-31603496 (-)



Homology
more
  • Human Ortholog
    NKRF, NFKB repressing factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NKRF, NFKB repressing factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ITBA4, NRF
  • Links
    NCBI Gene ID: 55922
    neXtProt AC: NX_O15226
    UniProt: O15226

  • Chr Location
    Xq24; chrX:119588337-119606464 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 84816
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NKRF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Homozygous female and hemizygous male null mice are viable and fertile with normal inflammatory responses, response to infection, peripheral blood cell populations and skin morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044149 Ensembl Gene Model | MGI Sequence Detail 15360 C57BL/6J ±  kb
transcript ENSMUST00000057093 Ensembl | MGI Sequence Detail 3268 Not Applicable  
polypeptide ENSMUSP00000061546 Ensembl | MGI Sequence Detail 690 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 2
    cDNA 36

    Microarray probesets 6
Other
Accession IDs
less
MGI:2148002, MGI:2148062
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory