Arpc2
Gene Detail

Symbol Name ID

Arpc2 actin related protein 2/3 complex, subunit 2 MGI:1923959

Synonyms

2210023N03Rik, p34-Arc

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.49 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:74236497-74268209 bp, + strand From VEGA annotation of GRCm38   31713 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Actin-related protein 2/3 complex subunit 2
Gene Tree: Arpc2

Human homologs

Human Homolog		ARPC2, actin related protein 2/3 complex, subunit 2, 34kDa
NCBI Gene ID		10109
neXtProt AC		NX_O15144
Human Synonyms		ARC34, p34-Arc, PNAS-139
Human Chr (Location)		2q36.1; chr2:219081874-219119071 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(73) : Targeted(3) Gene trapped(70)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	positive regulation of actin filament polymerization, positive regulation of substrate adhesion-dependent cell spreading, ...
Component	Arp2/3 protein complex, cell leading edge, ...
Function	actin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(233)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(234) cDNA(234)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016449 (Evidence)
Ensembl Gene Model	ENSMUSG00000006304 (Evidence)
Entrez Gene	76709 (Evidence)
UniGene	337038
DFCI	TC1584161, TC1706495, TC1734643
DoTS	DT.101200628, DT.101382715, DT.110549266, DT.496614, DT.94237560
NIA Mouse Gene Index	U000441
Consensus CDS Project	CCDS35612.1
International Mouse Knockout Project Status	Arpc2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016449	VEGA Gene Model | MGI Sequence Detail	31713	C57BL/6J
transcript	OTTMUST00000039637	VEGA | MGI Sequence Detail	1439	Not Applicable
polypeptide	OTTMUSP00000017692	VEGA | MGI Sequence Detail	300	Not Applicable

All sequences(45) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(168 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007188	Arp2/3 complex, 34kDa subunit p34-Arc
Protein Ontology	PR:000004310	actin-related protein 2/3 complex subunit 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185589 Maritzen T, et al., Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7
All references(45)