Plet1 MGI Mouse Gene Detail - MGI:1923759 - placenta expressed transcript 1

Symbol

Plet1
Name

placenta expressed transcript 1
Synonyms

0610037B23Rik, 1600029D21Rik, PLET1

Feature Type

protein coding gene
IDs

MGI:1923759
NCBI Gene: 76509
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr9:50405825-50416782 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 27.71 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923759	protein coding gene	Chr9:50405825-50416939 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034776	protein coding gene	Chr9:49383144-49395499 (+)
A/J	MGP_AJ_G0034757	protein coding gene	Chr9:47875543-47886612 (+)
AKR/J	MGP_AKRJ_G0034685	protein coding gene	Chr9:48886784-48897661 (+)
BALB/cJ	MGP_BALBcJ_G0034749	protein coding gene	Chr9:47600998-47611686 (+)
C3H/HeJ	MGP_C3HHeJ_G0034459	protein coding gene	Chr9:49370828-49381848 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035269	protein coding gene	Chr9:50761231-50774785 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032182	protein coding gene	Chr9:47346345-47358141 (+)
CAST/EiJ	MGP_CASTEiJ_G0033781	protein coding gene	Chr9:49318751-49330620 (+)
CBA/J	MGP_CBAJ_G0034431	protein coding gene	Chr9:52568764-52581709 (+)
DBA/2J	MGP_DBA2J_G0034590	protein coding gene	Chr9:47739600-47750851 (+)
FVB/NJ	MGP_FVBNJ_G0034531	protein coding gene	Chr9:46962849-46973982 (+)
LP/J	MGP_LPJ_G0034671	protein coding gene	Chr9:49744489-49756270 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034575	protein coding gene	Chr9:54170908-54181644 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035290	protein coding gene	Chr9:48864028-48874977 (+)
PWK/PhJ	MGP_PWKPhJ_G0033486	protein coding gene	Chr9:47716474-47728122 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033321	protein coding gene	Chr9:49175954-49186840 (+)
WSB/EiJ	MGP_WSBEiJ_G0033894	protein coding gene	Chr9:48862880-48877451 (+)

Human Ortholog

PLET1, placenta expressed transcript 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLET1, placenta expressed transcript 1
Synonyms

C11orf34
Links

HGNC:30053

NCBI Gene ID: 349633

neXtProt AC: NX_Q6UQ28

UniProt: Q6UQ28
Chr Location

11q23.1; chr11:112248153-112260860 (-) GRCh38

MGI Vertebrate Homology

Plet1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PLET1
Gene Tree

Plet1

less

Phenotype Summary

9 phenotypes from 3 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

5
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased gut permeability, impaired tissue repair of DSS-induced damage in colon epithelium, and reduced tumor formation in an azoxymethane/DSS model of colitis-associated cancer.

less

All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

86
cDNA Data

254
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS40619.1

Ensembl

ENSMUSG00000032068 (Evidence)
NCBI Gene

76509

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032068	Ensembl Gene Model \| MGI Sequence Detail	10958	C57BL/6J	± kb
transcript	ENSMUST00000114474	Ensembl \| MGI Sequence Detail	1689	Not Applicable
polypeptide	ENSMUSP00000110118	Ensembl \| MGI Sequence Detail	237	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000012866 placenta-expressed transcript 1 protein

(term hierarchy)
InterPro Domains

IPR026184 Placenta-expressed transcript 1

less

All nucleic 259

cDNA 254

Primer pair 4

Other 1

Microarray probesets 5

less

MGI:1915617, MGI:2142914, MGI:2143236

Summaries

All 52

Developmental Gene Expression 19

Gene Ontology 4

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:346010 Pervizaj-Oruqaj L, et al., Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia. Nat Commun. 2024 Jan 2;15(1):87

TSS for Plet1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2866	Chr9:50405348-50405357 (+)	-472 bp
Tssr85023	Chr9:50405439-50405446 (+)	-382 bp
Tssr85024	Chr9:50405533-50405572 (+)	-272 bp
Tssr85025	Chr9:50405816-50405833 (+)	0 bp
Tssr85026	Chr9:50408076-50408101 (+)	2,264 bp
Tssr85027	Chr9:50410444-50410464 (+)	4,629 bp
Tssr85028	Chr9:50410474-50410486 (+)	4,655 bp
Tssr85029	Chr9:50410509-50410522 (+)	4,691 bp
Tssr85030	Chr9:50410554-50410566 (+)	4,735 bp
Tssr85031	Chr9:50412365-50412391 (+)	6,553 bp
Tssr85032	Chr9:50415586-50415597 (+)	9,767 bp
Tssr85033	Chr9:50415605-50415646 (+)	9,801 bp
Tssr85034	Chr9:50415649-50415667 (+)	9,833 bp
Tssr85035	Chr9:50415852-50415866 (+)	10,034 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23