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Slc18b1 Gene Detail
Summary
  • Symbol
    Slc18b1
  • Name
    solute carrier family 18, subfamily B, member 1
  • Synonyms
    1110021L09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923556
    NCBI Gene: 76306
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:23672884-23703866 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 11.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923556
protein coding gene Chr10:23672876-23703867 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017073
protein coding gene Chr10:21719610-21751625 (+)
A/J MGP_AJ_G0017051
protein coding gene Chr10:21101986-21134237 (+)
AKR/J MGP_AKRJ_G0017013
protein coding gene Chr10:21445674-21480030 (+)
BALB/cJ MGP_BALBcJ_G0017013
protein coding gene Chr10:21178793-21208305 (+)
C3H/HeJ MGP_C3HHeJ_G0016833
protein coding gene Chr10:21643605-21677829 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017471
protein coding gene Chr10:22362148-22397131 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015172
protein coding gene Chr10:19827223-19858057 (+)
CAST/EiJ MGP_CASTEiJ_G0016414
protein coding gene Chr10:21537951-21572121 (+)
CBA/J MGP_CBAJ_G0016806
protein coding gene Chr10:23365955-23397014 (+)
DBA/2J MGP_DBA2J_G0016912
protein coding gene Chr10:20831025-20862869 (+)
FVB/NJ MGP_FVBNJ_G0016908
protein coding gene Chr10:20557618-20589654 (+)
LP/J MGP_LPJ_G0016988
protein coding gene Chr10:21704096-21739738 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016938
protein coding gene Chr10:23511646-23560598 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017506
protein coding gene Chr10:21295325-21330471 (+)
PWK/PhJ MGP_PWKPhJ_G0016199
protein coding gene Chr10:20576387-20608068 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015981
protein coding gene Chr10:21108603-21146635 (+)
WSB/EiJ MGP_WSBEiJ_G0016477
protein coding gene Chr10:21406940-21442261 (+)



Homology
more
  • Human Ortholog
    SLC18B1, solute carrier family 18 member B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC18B1, solute carrier family 18 member B1
  • Synonyms
    C6orf192, dJ55C23.6, VPAT
  • Links
    NCBI Gene ID: 116843
    neXtProt AC: NX_Q6NT16
    UniProt: Q6NT16

  • Chr Location
    6q23.2; chr6:132769370-132813339 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    10
  • Targeted
    2
  • Genomic Mutations
    1 involving Slc18b1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a conditional allele ubiquitously activated exhibit reduced brain polyamine levels, impaired memory and altered response to addictive substances.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037455 Ensembl Gene Model | MGI Sequence Detail 30983 C57BL/6J ±  kb
transcript ENSMUST00000119597 Ensembl | MGI Sequence Detail 2837 Not Applicable  
polypeptide ENSMUSP00000112634 Ensembl | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:282689 Fredriksson R, et al., The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain. PLoS Genet. 2019 Dec;15(12):e1008455

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory