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Fads1
Gene Detail
Symbol

Name
ID
Fads1
fatty acid desaturase 1
MGI:1923517
Synonyms
0710001O03Rik, A930006B21Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:10182888-10196870 bp, + strand
From Ensembl annotation of GRCm38

  13983 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: fatty acid desaturase/sphingolipid desaturase
Gene Tree: Fads1

Human
homologs
Human Homolog FADS1, fatty acid desaturase 1
NCBI Gene ID 3992
neXtProt AC  NX_O60427
Human Synonyms  D5D, FADS6, FADSD5, LLCDL1, TU12
Human Chr (Location)  11q12.2-q13.1; chr11:61799625-61817057 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit arachidonic acid deficiency with premature lethality and altered prostaglandin levels. Heterozygous mice exhibit an intermediate phenotype.
 
Interactions
Fads1 interacts with 220 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process arachidonic acid metabolic process, cellular response to starvation, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function acyl-CoA desaturase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (105)    Tissues (96)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 105
cDNA source data(265)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(265) cDNA(265)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000010663 (Evidence)
Entrez Gene76267 (Evidence)
UniGene30158
DFCITC1573976, TC1587987
DoTSDT.101738640, DT.110852363, DT.87041753, DT.87047403, DT.97356683
NIA Mouse Gene IndexU019152
EC1.14.19.-
Consensus CDS ProjectCCDS29572.1
International Mouse Knockout Project StatusFads1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010663 Ensembl Gene Model | MGI Sequence Detail 13983 C57BL/6J ±  kb
transcript ENSMUST00000010807 Ensembl | MGI Sequence Detail 3456 Not Applicable 
polypeptide ENSMUSP00000010807 Ensembl | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001199 Cytochrome b5-like heme/steroid binding domain
InterPro IPR005804 Fatty acid desaturase, type 1
InterPro IPR012171 Fatty acid/sphingolipid desaturase
Protein Ontology PR:000007317 fatty acid desaturase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210042 Ichi I, et al., Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency. Biochim Biophys Acta. 2014 Jan;1841(1):204-13
All references(42)
Other
accession IDs
MGI:1924436, MGI:2147505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory