Fads1
Gene Detail

Symbol Name ID

Fads1 fatty acid desaturase 1 MGI:1923517

Synonyms

0710001O03Rik, A930006B21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19

6.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:10182888-10196870 bp, + strand From Ensembl annotation of GRCm38   13983 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: fatty acid desaturase/sphingolipid desaturase
Gene Tree: Fads1

Human homologs

Human Homolog		FADS1, fatty acid desaturase 1
NCBI Gene ID		3992
neXtProt AC		NX_O60427
Human Synonyms		D5D, FADS6, FADSD5, LLCDL1, TU12
Human Chr (Location)		11q12.2-q13.1; chr11:61567097-61584529 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

Mice homozygous for a knock-out allele exhibit arachidonic acid deficiency with premature lethality and altered prostaglandin levels. Heterozygous mice exhibit an intermediate phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	arachidonic acid metabolic process, cellular response to starvation, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	heme binding, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (105)    Tissues (96)    Images (21)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	105

cDNA source data(262)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(262) cDNA(262)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000010663 (Evidence)
Entrez Gene	76267 (Evidence)
UniGene	30158
DFCI	TC1573976, TC1587987
DoTS	DT.101738640, DT.110852363, DT.87041753, DT.87047403, DT.97356683
NIA Mouse Gene Index	U019152
EC	1.14.19.-
Consensus CDS Project	CCDS29572.1
International Mouse Knockout Project Status	Fads1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000010663	Ensembl Gene Model | MGI Sequence Detail	13983	C57BL/6J
transcript	ENSMUST00000010807	Ensembl | MGI Sequence Detail	3456	Not Applicable
polypeptide	ENSMUSP00000010807	Ensembl | MGI Sequence Detail	447	Not Applicable

All sequences(64) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001199	Cytochrome b5
InterPro	IPR005804	Fatty acid desaturase, type 1
InterPro	IPR012171	Fatty acid/sphingolipid desaturase
Protein Ontology	PR:000007317	fatty acid desaturase 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186265 Fan YY, et al., Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model. J Lipid Res. 2012 Jul;53(7):1287-95
All references(39)

Other accession IDs

MGI:1924436, MGI:2147505