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Grhpr
Gene Detail
Symbol

Name
ID
Grhpr
glyoxylate reductase/hydroxypyruvate reductase
MGI:1923488
Synonyms
1110059D05Rik, 6430629L09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
23.65 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:44981395-44990734 bp, + strand
From VEGA annotation of GRCm38

  9340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRHPR
Protein SuperFamily: phosphoglycerate dehydrogenase
Gene Tree: Grhpr

Human
homologs
GRHPR, glyoxylate reductase/hydroxypyruvate reductase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9380
neXtProt AC: NX_Q9UBQ7

Human Synonyms: GLXR, GLYD, PH2

Human Chr (Location): 9q12; chr9:37422666-37436993 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GRHPR

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit primary hyperoxaluria.
 
Human Diseases Modeled in Mice Using Grhpr (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Grhpr interacts with 19 markers (Mir22, Mir31, Mir96, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process dicarboxylic acid metabolic process, excretion, ...
Component cytoplasm, cytosol, ...
Function carboxylic acid binding, glycerate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (100)    Tissues (95)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
cDNA source data(155)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grhpr.1, grhpr.2 ; ZFIN grhpra, grhprb    NEW 
Molecular
reagents
All nucleic(155) cDNA(155)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000007141 (Evidence)
Ensembl Gene Model ENSMUSG00000035637 (Evidence)
Entrez Gene 76238 (Evidence)
UniGene 196574
DFCI TC1575653, TC1654148
DoTS DT.495180
NIA Mouse Gene Index U004265
EC 1.1.1.79, 1.1.1.81
Consensus CDS Project CCDS18128.1
International Mouse Phenotyping Consortium Status Grhpr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007141 VEGA Gene Model | MGI Sequence Detail 9340 C57BL/6J ±  kb
transcript OTTMUST00000016479 VEGA | MGI Sequence Detail 1280 Not Applicable 
polypeptide OTTMUSP00000007553 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(3) UniProt(5)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008232 glyoxylate reductase/hydroxypyruvate reductase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181969 Knight J, et al., Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Am J Physiol Renal Physiol. 2012 Mar;302(6):F688-93
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:1916037

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory