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Grhpr
Gene Detail
 Symbol
Name
ID
Grhpr
glyoxylate reductase/hydroxypyruvate reductase
MGI:1923488
Synonyms 1110059D05Rik, 6430629L09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
23.65 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:44981395-44990734 bp, + strand
From VEGA annotation of GRCm38

  9340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphoglycerate dehydrogenase
Gene Tree: Grhpr

Human
homologs
Human Homolog GRHPR, glyoxylate reductase/hydroxypyruvate reductase
NCBI Gene ID 9380
neXtProt AC  NX_Q9UBQ7
Human Synonyms  GLXR, GLYD, PH2
Human Chr (Location)  9q12; chr9:37422696-37436993 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRHPR
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit primary hyperoxaluria.
 
Human Diseases Modeled Using Mouse Grhpr (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process dicarboxylic acid metabolic process, excretion, ...
Component cytoplasm, cytosol, ...
Function carboxylic acid binding, glycerate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (100)    Tissues (95)    Images (11)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 100
cDNA source data(155)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(155) cDNA(155)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000007141 (Evidence)
Ensembl Gene ModelENSMUSG00000035637 (Evidence)
Entrez Gene76238 (Evidence)
UniGene196574
DFCITC1575653, TC1654148
DoTSDT.495180
NIA Mouse Gene IndexU004265
EC1.1.1.79, 1.1.1.81
Consensus CDS ProjectCCDS18128.1
International Mouse Knockout Project StatusGrhpr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007141 VEGA Gene Model | MGI Sequence Detail 9340 C57BL/6J ±  kb
transcript OTTMUST00000016479 VEGA | MGI Sequence Detail 1280 Not Applicable 
polypeptide OTTMUSP00000007553 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(3) UniProt(5)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008232 glyoxylate reductase/hydroxypyruvate reductase
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181969 Knight J, et al., Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Am J Physiol Renal Physiol. 2012 Mar;302(6):F688-93
All references(37)
Other
accession IDs
MGI:1916037

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory