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Grhpr Gene Detail
Summary
  • Symbol
    Grhpr
  • Name
    glyoxylate reductase/hydroxypyruvate reductase
  • Synonyms
    1110059D05Rik, 6430629L09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923488
    NCBI Gene: 76238
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:44981395-44990734 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.65 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923488
 protein coding gene Chr4:44981394-44990734 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028237
 protein coding gene Chr4:43187680-43197019 (+)
A/J MGP_AJ_G0028194
 protein coding gene Chr4:41644584-41653923 (+)
AKR/J MGP_AKRJ_G0028146
 protein coding gene Chr4:42635963-42645302 (+)
BALB/cJ MGP_BALBcJ_G0028214
 protein coding gene Chr4:41729613-41738952 (+)
C3H/HeJ MGP_C3HHeJ_G0027936
 protein coding gene Chr4:43238892-43248231 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028655
 protein coding gene Chr4:44826809-44836148 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025965
 protein coding gene Chr4:39042664-39052160 (+)
CAST/EiJ MGP_CASTEiJ_G0027375
 protein coding gene Chr4:42790071-42800433 (+)
CBA/J MGP_CBAJ_G0027902
 protein coding gene Chr4:46207205-46216544 (+)
DBA/2J MGP_DBA2J_G0028051
 protein coding gene Chr4:41543401-41552740 (+)
FVB/NJ MGP_FVBNJ_G0028018
 protein coding gene Chr4:40767677-40777016 (+)
LP/J MGP_LPJ_G0028150
 protein coding gene Chr4:43248009-43257348 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028042
 protein coding gene Chr4:49362666-49372005 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028691
 protein coding gene Chr4:42841006-42850349 (+)
PWK/PhJ MGP_PWKPhJ_G0027100
 protein coding gene Chr4:41604639-41615081 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026928
 protein coding gene Chr4:42369514-42378825 (+)
WSB/EiJ MGP_WSBEiJ_G0027453
 protein coding gene Chr4:42726366-42735789 (+)



Homology
more
  • Human Ortholog
    GRHPR, glyoxylate and hydroxypyruvate reductase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRHPR, glyoxylate and hydroxypyruvate reductase
  • Synonyms
    GLXR, GLYD, PH2
  • Links
    NCBI Gene ID: 9380
    neXtProt AC: NX_Q9UBQ7
    UniProt: Q9UBQ7

  • Chr Location
    9p13.2; chr9:37422435-37439494 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Grhpr mouse models; 2 with human GRHPR associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit primary hyperoxaluria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    95
  • cDNA Data
    156
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035637 Ensembl Gene Model | MGI Sequence Detail 9340 C57BL/6J ±  kb
    transcript ENSMUST00000045078 Ensembl | MGI Sequence Detail 1280 Not Applicable  
    polypeptide ENSMUSP00000047218 Ensembl | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008232 glyoxylate reductase/hydroxypyruvate reductase
      (term hierarchy)
    • EC
      1.1.1.79, 1.1.1.81
    • InterPro Domains
      IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
      IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
      IPR036291 NAD(P)-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 156
      cDNA 156

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916037
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:283585 Buchalski B, et al., The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165633
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory