Grhpr
Gene Detail

Symbol Name ID

Grhpr glyoxylate reductase/hydroxypyruvate reductase MGI:1923488

Synonyms

1110059D05Rik, 6430629L09Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 4

23.65 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:44981395-44990734 bp, + strand From VEGA annotation of GRCm38   9340 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphoglycerate dehydrogenase
Gene Tree: Grhpr

Human homologs

Human Homolog		GRHPR, glyoxylate reductase/hydroxypyruvate reductase
NCBI Gene ID		9380
neXtProt AC		NX_Q9UBQ7
Human Synonyms		GLXR, GLYD, PH2
Human Chr (Location)		9q12; chr9:37422707-37436986 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GRHPR

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a gene trap allele exhibit primary hyperoxaluria.

 
Human Diseases Modeled Using Mouse Grhpr (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	dicarboxylic acid metabolic process, excretion, ...
Component	cytoplasm, cytosol
Function	carboxylic acid binding, cofactor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (100)    Tissues (95)    Images (11)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	100

cDNA source data(155)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(155) cDNA(155)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000007141 (Evidence)
Ensembl Gene Model	ENSMUSG00000035637 (Evidence)
Entrez Gene	76238 (Evidence)
UniGene	196574
DFCI	TC1575653, TC1654148
DoTS	DT.495180
NIA Mouse Gene Index	U004265
EC	1.1.1.79, 1.1.1.81
Consensus CDS Project	CCDS18128.1
International Mouse Knockout Project Status	Grhpr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007141	VEGA Gene Model | MGI Sequence Detail	9340	C57BL/6J
transcript	OTTMUST00000016479	VEGA | MGI Sequence Detail	1280	Not Applicable
polypeptide	OTTMUSP00000007553	VEGA | MGI Sequence Detail	328	Not Applicable

All sequences(42) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(108 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000008232	glyoxylate reductase/hydroxypyruvate reductase

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181969 Knight J, et al., Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Am J Physiol Renal Physiol. 2012 Mar;302(6):F688-93
All references(37)

Other accession IDs

MGI:1916037