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Arhgap15
Gene Detail
Symbol

Name
ID
Arhgap15
Rho GTPase activating protein 15
MGI:1923367
Synonyms
5830480G12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
26.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:43748824-44395953 bp, + strand
From VEGA annotation of GRCm38

  647130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41271  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Arhgap15

Human
homologs
Human Homolog ARHGAP15, Rho GTPase activating protein 15
NCBI Gene ID 55843
neXtProt AC  NX_Q53QZ3
Human Synonyms  BM046
Human Chr (Location)  2q22.2-q22.3; chr2:143129330-143768352 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene display reduced leukocyte numbers and abnormally shaped macrophage. Chemotactic responses of macrophage are normal while neutrophile chemoattraction and bacterial pagocytosis are increased.
 
Interactions
Arhgap15 interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process positive regulation of Rac GTPase activity, regulation of cell shape, ...
Component cytoplasm, intracellular, ...
Function GTPase activator activity, Rac GTPase activator activity
External Resources: FuncBase
Expression
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012329 (Evidence)
Ensembl Gene ModelENSMUSG00000049744 (Evidence)
Entrez Gene76117 (Evidence)
UniGene217350
DFCITC1581442, TC1605686, TC1617195
DoTSDT.87025133, DT.91557114, DT.40164450, DT.101734707, DT.94245526, DT.94268942, DT.97404705, DT.97376802
NIA Mouse Gene IndexU001717
Consensus CDS ProjectCCDS16019.1
International Mouse Knockout Project StatusArhgap15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012329 VEGA Gene Model | MGI Sequence Detail 647130 C57BL/6J ±  kb
transcript OTTMUST00000029352 VEGA | MGI Sequence Detail 2604 Not Applicable 
polypeptide OTTMUSP00000013237 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(22) UniProt(5)
Polymorphisms
SNPs within 2kb(4978 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR015767 Rho GTPase activating
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004222 rho GTPase-activating protein 15
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:174896 Costa C, et al., The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. Blood. 2011 Jul 28;118(4):1099-108
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory