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Arhgap15
Gene Detail
Symbol

Name
ID
Arhgap15
Rho GTPase activating protein 15
MGI:1923367
Synonyms
5830480G12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
26.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:43748824-44395953 bp, + strand
From VEGA annotation of GRCm38

  647130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41271  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARHGAP15
Gene Tree: Arhgap15

Human
homologs
ARHGAP15, Rho GTPase activating protein 15
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55843
neXtProt AC: NX_Q53QZ3

Human Synonyms: BM046

Human Chr (Location): 2q22.2-q22.3; chr2:143070968-143768352 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene display reduced leukocyte numbers and abnormally shaped macrophage. Chemotactic responses of macrophage are normal while neutrophile chemoattraction and bacterial pagocytosis are increased.
 
Interactions
Arhgap15 interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process positive regulation of GTPase activity, regulation of cell shape, ...
Component cytoplasm, membrane
Function GTPase activator activity
External Resources: FuncBase
Expression
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ARHGAP15    NEW 
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000012329 (Evidence)
Ensembl Gene Model ENSMUSG00000049744 (Evidence)
Entrez Gene 76117 (Evidence)
UniGene 217350
DFCI TC1605686, TC1581442, TC1617195
DoTS DT.97404705, DT.101734707, DT.97376802, DT.40164450, DT.94268942, DT.87025133, DT.91557114, DT.94245526
NIA Mouse Gene Index U001717
Consensus CDS Project CCDS16019.1
International Mouse Phenotyping Consortium Status Arhgap15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012329 VEGA Gene Model | MGI Sequence Detail 647130 C57BL/6J ±  kb
transcript OTTMUST00000029352 VEGA | MGI Sequence Detail 2604 Not Applicable 
polypeptide OTTMUSP00000013237 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(21) UniProt(3)
Polymorphisms
SNPs within 2kb(4978 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR015767 Rho GTPase activating
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004222 rho GTPase-activating protein 15
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:174896 Costa C, et al., The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. Blood. 2011 Jul 28;118(4):1099-108
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory