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Ispd
Gene Detail
Symbol

Name
ID
Ispd
isoprenoid synthase domain containing
MGI:1923097
Synonyms
4930579E17Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
16.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:36381519-36689444 bp, + strand
From Ensembl annotation of GRCm38

  307926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ISPD
Gene Tree: Ispd

Human
homologs
ISPD, isoprenoid synthase domain containing
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 729920
neXtProt AC: NX_A4D126

Human Synonyms: hCG_1745121, MDDGA7, MDDGC7, Nip

Human Chr (Location): 7p21.2; chr7:15916851-16530558 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ISPD

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Chemically induced (ENU)(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit neonatal lethality due to respiratory failure, abnormal axon guidance and fasciculation, abnormal dorsal funiculus, detachment of radial glial cell endfeet and neuronal heterotopias.
 
Interactions
Ispd interacts with 203 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ispd ; ZFIN ispd    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000043153 (Evidence)
Entrez Gene 75847 (Evidence)
DFCI TC1584647, TC1590559, TC1593909, TC1631428
DoTS DT.101274223, DT.101734351, DT.55280733, DT.87053335, DT.91580193, DT.94274519, DT.97334492
NIA Mouse Gene Index U040762
EC 2.7.7.-
Consensus CDS Project CCDS49051.1
International Mouse Phenotyping Consortium Status Ispd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043153 Ensembl Gene Model | MGI Sequence Detail 307926 C57BL/6J ±  kb
transcript ENSMUST00000062041 Ensembl | MGI Sequence Detail 2690 Not Applicable 
polypeptide ENSMUSP00000061646 Ensembl | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(19) UniProt(1)
Polymorphisms
SNPs within 2kb(2016 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001228 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
InterPro IPR018294 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site
Protein Ontology PR:000031039 isoprenoid synthase domain-containing protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215959 Yagi H, et al., AGO61-dependent GlcNAc modification primes the formation of functional glycans on alpha-dystroglycan. Sci Rep. 2013;3:3288
All references(28)
Other
accession IDs
MGI:2144979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory