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Crppa Gene Detail
Summary
  • Symbol
    Crppa
  • Name
    CDP-L-ribitol pyrophosphorylase A
  • Synonyms
    4930579E17Rik, Ispd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923097
    NCBI Gene: 75847
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:36381450-36689503 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 16.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2010 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923097
protein coding gene Chr12:36380335-36689503 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019694
protein coding gene Chr12:34616532-34922738 (+)
A/J MGP_AJ_G0019660
protein coding gene Chr12:33529568-33836146 (+)
AKR/J MGP_AKRJ_G0019631
protein coding gene Chr12:34564610-34868332 (+)
BALB/cJ MGP_BALBcJ_G0019638
protein coding gene Chr12:33736327-34032208 (+)
C3H/HeJ MGP_C3HHeJ_G0019442
protein coding gene Chr12:34502635-34816779 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020085
protein coding gene Chr12:35581728-35923316 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017709
protein coding gene Chr12:32633077-32926194 (+)
CAST/EiJ MGP_CASTEiJ_G0018995
protein coding gene Chr12:29556370-29869054 (+)
CBA/J MGP_CBAJ_G0019414
protein coding gene Chr12:36777034-37103257 (+)
DBA/2J MGP_DBA2J_G0019527
protein coding gene Chr12:33370667-33667658 (+)
FVB/NJ MGP_FVBNJ_G0019516
protein coding gene Chr12:33092294-33389121 (+)
LP/J MGP_LPJ_G0019597
protein coding gene Chr12:34696805-35019449 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019552
protein coding gene Chr12:36433820-36768612 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020125
protein coding gene Chr12:34090247-34391187 (+)
PWK/PhJ MGP_PWKPhJ_G0018762
protein coding gene Chr12:28050060-28357110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018552
protein coding gene Chr12:28712848-29024705 (+)
WSB/EiJ MGP_WSBEiJ_G0019045
protein coding gene Chr12:34348234-34657649 (+)



Homology
more
  • Human Ortholog
    CRPPA, CDP-L-ribitol pyrophosphorylase A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRPPA, CDP-L-ribitol pyrophosphorylase A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hISPD, ISPD, LGMDR20, MDDGA7, MDDGC7, Nip
  • Links
    NCBI Gene ID: 729920
    neXtProt AC: NX_A4D126
    UniProt: A4D126

  • Chr Location
    7p21.2; chr7:16087527-16422562 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 45614
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRPPA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CRPPA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit neonatal lethality due to respiratory failure, abnormal axon guidance and fasciculation, abnormal dorsal funiculus, detachment of radial glial cell endfeet and neuronal heterotopias.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043153 Ensembl Gene Model | MGI Sequence Detail 308054 C57BL/6J ±  kb
    transcript ENSMUST00000062041 Ensembl | MGI Sequence Detail 2690 Not Applicable  
    polypeptide ENSMUSP00000061646 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031039 D-ribitol-5-phosphate cytidylyltransferase
    • EC
    • InterPro Domains
      IPR018294 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site
      IPR034683 Cytidylyltransferase IspD/TarI
      IPR040635 D-ribitol-5-phosphate cytidylyltransferase, C-terminal
      IPR029044 Nucleotide-diphospho-sugar transferases
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144979
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:266267 Clements R, et al., Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan. Dev Biol. 2018 Oct 15;442(2):210-219

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory