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Ispd
Gene Detail
 Symbol
Name
ID
Ispd
isoprenoid synthase domain containing
MGI:1923097
Synonyms 4930579E17Rik
Feature Type protein coding gene
Genetic Map
Chromosome 12
16.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:36381519-36689444 bp, + strand
From NCBI annotation of GRCm38

  307926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ispd

Human
homologs
Human Homolog ISPD, isoprenoid synthase domain containing
NCBI Gene ID 729920
neXtProt AC  NX_A4D126
Human Synonyms  hCG_1745121, MDDGA7, Nip
Human Chr (Location)  7p21.2; chr7:16087527-16421322 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ISPD
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Chemically induced (ENU)(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit neonatal lethality due to respiratory failure, abnormal axon guidance and fasciculation, abnormal dorsal funiculus, detachment of radial glial cell endfeet and neuronal heterotopias.
 
Interactions
Ispd interacts with 204 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process axon guidance, isoprenoid biosynthetic process, ...
Component cellular_component
Function ATP:coenzyme F420 adenylyltransferase activity, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000043153 (Evidence)
Entrez Gene75847 (Evidence)
DFCITC1584647, TC1590559, TC1593909, TC1631428
DoTSDT.101274223, DT.101734351, DT.55280733, DT.87053335, DT.91580193, DT.94274519, DT.97334492
NIA Mouse Gene IndexU040762
EC2.7.7.-
Consensus CDS ProjectCCDS49051.1
International Mouse Knockout Project StatusIspd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 75847 NCBI Gene Model | MGI Sequence Detail 307926 C57BL/6J ±  kb
transcript NM_001289504 RefSeq | MGI Sequence Detail 3246 C57BL/6 
polypeptide Q5RJG7 UniProt | EBI | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(10) UniProt(1)
Polymorphisms SNPs within 2kb(2016 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001228 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
InterPro IPR018294 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site
Protein Ontology PR:000031039 isoprenoid synthase domain-containing protein
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194150 Wright KM, et al., Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron. 2012 Dec 6;76(5):931-44
All references(28)
Other
accession IDs
MGI:2144979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory