Gns
Gene Detail

Symbol Name ID

Gns glucosamine (N-acetyl)-6-sulfatase MGI:1922862

Synonyms

2610016K11Rik, G6S

Feature Type

protein coding gene

Genetic Map

Chromosome 10

69.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:121365090-121397245 bp, + strand From NCBI annotation of GRCm38   32156 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1568  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: N-acetylglucosamine-6-sulfatase
Gene Tree: Gns

Human homologs

Human Homolog		GNS, glucosamine (N-acetyl)-6-sulfatase
NCBI Gene ID		2799
neXtProt AC		NX_P15586
Human Synonyms		G6S
Human Chr (Location)		12q14; chr12:64713442-64759446 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human GNS

Alleles and phenotypes

All alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	glycosaminoglycan metabolic process, metabolic process
Component	extracellular vesicular exosome, lysosome
Function	catalytic activity, glycosaminoglycan binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (118)    Tissues (112)    Images (13)
Theiler Stages: 20, 22, 23, 24

Assay Type	Results
RNA in situ	118

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(26) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000034707 (Evidence)
Entrez Gene	75612 (Evidence)
DFCI	TC1573519, TC1588595, TC1591255
DoTS	DT.101167322, DT.101186952, DT.103569227, DT.40167925, DT.91445005
NIA Mouse Gene Index	U012102
EC	3.1.6.14
Consensus CDS Project	CCDS24210.1
International Mouse Knockout Project Status	Gns

Sequences

Length	Strain/Species
genomic	75612	NCBI Gene Model | MGI Sequence Detail	32156	C57BL/6J
transcript	NM_029364	RefSeq | MGI Sequence Detail	3855	C57BL/6
polypeptide	Q8BFR4	UniProt | EBI | MGI Sequence Detail	544	Not Applicable

All sequences(91) RefSeq(2) UniProt(5)

Polymorphisms

SNPs within 2kb(488 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
InterPro	IPR017850	Alkaline-phosphatase-like, core domain
InterPro	IPR012251	N-acetylglucosamine-6-sulfatase
InterPro	IPR015981	N-acetylglucosamine-6-sulfatase, eukaryotic
InterPro	IPR000917	Sulfatase
InterPro	IPR024607	Sulfatase, conserved site
Protein Ontology	PR:000008129	N-acetylglucosamine-6-sulfatase

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)

Other accession IDs

MGI:2143761, MGI:2143948, MGI:2143956