Gns MGI Mouse Gene Detail - MGI:1922862 - glucosamine (N-acetyl)-6-sulfatase

Gns Gene Detail

Symbol

Gns
Name

glucosamine (N-acetyl)-6-sulfatase
Synonyms

2610016K11Rik, G6S

Feature Type

protein coding gene
IDs

MGI:1922862
NCBI Gene: 75612
Alliance

gene page

Sequence Map

Chr10:121365090-121397245 bp, + strand
From NCBI annotation of GRCm38

Mouse Genome Browser
Download
Sequence

32156 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 69.62 cM
Mapping Data

2 experiments

Human Ortholog

GNS, glucosamine (N-acetyl)-6-sulfatase

Vertebrate Orthologs

11

Human Ortholog

GNS, glucosamine (N-acetyl)-6-sulfatase
Orthology source: HomoloGene, HGNC
Synonyms

G6S
Links

HGNC:4422

NCBI Gene ID: 2799

neXtProt AC: NX_P15586

UniProt: P15586
Chr Location

12q14.3; chr12:64713442-64759446 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1568
1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GNS
Protein SuperFamily

N-acetylglucosamine-6-sulfatase
Gene Tree

Gns

Diseases

1 with human GNS associations

				Human Disease	Mouse Models
				mucopolysaccharidosis III IDs mucopolysaccharidosis III DOID:12801 DOID:14729 DOID:14788 ICD10CM:E76.22 MESH:D009084 NCI:C61262 NCI:C84897 NCI:C84898 OMIM:252900 OMIM:252920 OMIM:252930 OMIM:252940 ORDO:581 UMLS_CUI:C0026706 UMLS_CUI:C0086647 UMLS_CUI:C0086648

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

8
Gene trapped

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

11
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

118
Tissues

112
cDNA Data

26
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Gns interacts with 277 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

101
RefSeq

2
UniProt

8
CCDS

CCDS24210.1

Ensembl

ENSMUSG00000034707 (Evidence)
NCBI Gene

75612

			Length	Strain/Species	Flank
genomic	75612	NCBI Gene Model \| MGI Sequence Detail	32156	C57BL/6J	± kb
transcript	NM_029364	RefSeq \| MGI Sequence Detail	3855	C57BL/6
polypeptide	Q8BFR4	UniProt \| EBI \| MGI Sequence Detail	544	Not Applicable

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SNPs within 2kb

486 from dbSNP Build 142

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UniProt

8 Sequences
Protein Ontology

PR:000008129 N-acetylglucosamine-6-sulfatase

(term hierarchy)
EC

3.1.6.14
InterPro Domains

IPR017849 Alkaline phosphatase-like, alpha/beta/alpha

IPR017850 Alkaline-phosphatase-like, core domain superfamily

IPR012251 N-acetylglucosamine-6-sulfatase

IPR015981 N-acetylglucosamine-6-sulfatase, metazoan

IPR024607 Sulfatase, conserved site

IPR000917 Sulfatase, N-terminal

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All nucleic 27

cDNA 26

Other 1

Microarray probesets 5

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MGI:2143761, MGI:2143948, MGI:2143956

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 4
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:242250 Roca C, et al., Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID. Hum Mol Genet. 2017 Apr 15;26(8):1535-1551

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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