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Gns Gene Detail
Summary
  • Symbol
    Gns
  • Name
    glucosamine (N-acetyl)-6-sulfatase
  • Synonyms
    2610016K11Rik, G6S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922862
    NCBI Gene: 75612
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:121365090-121397245 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      32156 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 69.62 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GNS, glucosamine (N-acetyl)-6-sulfatase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GNS, glucosamine (N-acetyl)-6-sulfatase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G6S
  • Links
    NCBI Gene ID: 2799
    neXtProt AC: NX_P15586
    UniProt: P15586

  • Chr Location
    12q14.3; chr12:64713442-64759446 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Gns mouse models; 1 with human GNS associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO results in progressive lysosomal glycosaminoglycan accumulation in the central nervous system and peripheral organs and causes hypoactivity and shortened lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    118
  • Tissues
    112
  • cDNA Data
    26
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75612 NCBI Gene Model | MGI Sequence Detail 32156 C57BL/6J ±  kb
transcript NM_029364 RefSeq | MGI Sequence Detail 3855 C57BL/6  
polypeptide Q8BFR4 UniProt | EBI | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    486 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • EC
    3.1.6.14
  • InterPro Domains
    IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
    IPR012251 N-acetylglucosamine-6-sulfatase
    IPR015981 N-acetylglucosamine-6-sulfatase, metazoan
    IPR024607 Sulfatase, conserved site
    IPR000917 Sulfatase, N-terminal
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143761, MGI:2143948, MGI:2143956
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:242250 Roca C, et al., Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID. Hum Mol Genet. 2017 Apr 15;26(8):1535-1551
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2018
MGI 6.12 		The Jackson Laboratory