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Gns Gene Detail
Summary
  • Symbol
    Gns
  • Name
    glucosamine (N-acetyl)-6-sulfatase
  • Synonyms
    2610016K11Rik, G6S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922862
    NCBI Gene: 75612
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:121200995-121233154 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 69.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1530 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922862
 protein coding gene Chr10:121200995-121233159 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017781
 protein coding gene Chr10:124621675-124653589 (+)
A/J MGP_AJ_G0017756
 protein coding gene Chr10:119661469-119693970 (+)
AKR/J MGP_AKRJ_G0017719
 protein coding gene Chr10:123235048-123267189 (+)
BALB/cJ MGP_BALBcJ_G0017720
 protein coding gene Chr10:120053957-120087139 (+)
C3H/HeJ MGP_C3HHeJ_G0017544
 protein coding gene Chr10:123445631-123477775 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018175
 protein coding gene Chr10:128860148-128893770 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015855
 protein coding gene Chr10:113991599-114024795 (+)
CAST/EiJ MGP_CASTEiJ_G0017104
 protein coding gene Chr10:123809259-123845961 (+)
CBA/J MGP_CBAJ_G0017513
 protein coding gene Chr10:134103092-134139667 (+)
DBA/2J MGP_DBA2J_G0017619
 protein coding gene Chr10:118786141-118819251 (+)
FVB/NJ MGP_FVBNJ_G0017614
 protein coding gene Chr10:117769358-117801656 (+)
LP/J MGP_LPJ_G0017693
 protein coding gene Chr10:125155373-125189171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017643
 protein coding gene Chr10:136647510-136680013 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018215
 protein coding gene Chr10:123262156-123296407 (+)
PWK/PhJ MGP_PWKPhJ_G0016889
 protein coding gene Chr10:118902996-118936040 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016680
 protein coding gene Chr10:122149793-122182909 (+)
WSB/EiJ MGP_WSBEiJ_G0017165
 protein coding gene Chr10:123484359-123517757 (+)



Homology
more
  • Human Ortholog
    GNS, glucosamine (N-acetyl)-6-sulfatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNS, glucosamine (N-acetyl)-6-sulfatase
  • Synonyms
    G6S
  • Links
    NCBI Gene ID: 2799
    UniProt: P15586

  • Chr Location
    12q14.3; chr12:64713445-64759431 (-)  GRCh38
  • MGI Vertebrate Homology
    Gns stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: GNS
  • Protein SuperFamily
    G6S
  • Gene Tree
    Gns
Human Diseases
more
  • Diseases
    1 with Gns mouse models; 2 with human GNS associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO results in progressive lysosomal glycosaminoglycan accumulation in the central nervous system and peripheral organs and causes hypoactivity and shortened lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    114
  • cDNA Data
    27
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034707 Ensembl Gene Model | MGI Sequence Detail 32160 C57BL/6J ±  kb
transcript ENSMUST00000040344 Ensembl | MGI Sequence Detail 3855 Not Applicable  
polypeptide ENSMUSP00000043167 Ensembl | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008129 N-acetylglucosamine-6-sulfatase
    (term hierarchy)
  • EC
    3.1.6.14
  • InterPro Domains
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
    IPR012251 N-acetylglucosamine-6-sulfatase
    IPR032506 N-sulphoglucosamine sulphohydrolase, C-terminal
    IPR024607 Sulfatase, conserved site
    IPR000917 Sulfatase, N-terminal
  • GlyGen
    Q8BFR4 13 sites, 11 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 29
    cDNA 27
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143761, MGI:2143948, MGI:2143956
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 12
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:359821 Wang F, et al., Enzyme Replacement Therapy for Mucopolysaccharidosis IIID using Recombinant Human alpha-N-Acetylglucosamine-6-Sulfatase in Neonatal Mice. Mol Pharm. 2021 Jan 4;18(1):214-227
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory