About   Help   FAQ
Gns
Gene Detail
Symbol

Name
ID
Gns
glucosamine (N-acetyl)-6-sulfatase
MGI:1922862
Synonyms
2610016K11Rik, G6S
Feature Type
protein coding gene
Genetic Map
Chromosome 10
69.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:121365090-121397245 bp, + strand
From Ensembl annotation of GRCm38

  32156 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1568  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: N-acetylglucosamine-6-sulfatase
Gene Tree: Gns

Human
homologs
Human Homolog   GNS, glucosamine (N-acetyl)-6-sulfatase
NCBI Gene ID 2799
neXtProt AC  NX_P15586
Human Synonyms  G6S
Human Chr (Location)  12q14; chr12:64713442-64759446 (-)  GRCh38.p2
Disease Associations  (1) Diseases Associated with Human GNS
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gns interacts with 277 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process glycosaminoglycan metabolic process, metabolic process
Component extracellular exosome, lysosome
Function catalytic activity, glycosaminoglycan binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (112)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(26) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000034707 (Evidence)
Entrez Gene75612 (Evidence)
DFCITC1573519, TC1588595, TC1591255
DoTSDT.103569227, DT.101186952, DT.101167322, DT.91445005, DT.40167925
NIA Mouse Gene IndexU012102
EC3.1.6.14
Consensus CDS ProjectCCDS24210.1
International Mouse Knockout Project StatusGns
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034707 Ensembl Gene Model | MGI Sequence Detail 32156 C57BL/6J ±  kb
transcript ENSMUST00000040344 Ensembl | MGI Sequence Detail 3855 Not Applicable 
polypeptide ENSMUSP00000043167 Ensembl | MGI Sequence Detail 544 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(488 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR012251 N-acetylglucosamine-6-sulfatase
InterPro IPR015981 N-acetylglucosamine-6-sulfatase, eukaryotic
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000008129 N-acetylglucosamine-6-sulfatase
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)
Other
accession IDs
MGI:2143761, MGI:2143948, MGI:2143956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/12/2015
MGI 5.21
The Jackson Laboratory