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Oplah
Gene Detail
Symbol

Name
ID
Oplah
5-oxoprolinase (ATP-hydrolysing)
MGI:1922725
Synonyms
MGC:28663, MGC:36824
Feature Type
protein coding gene
Genetic Map
Chromosome 15
35.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:76296597-76328015 bp, - strand
From VEGA annotation of GRCm38

  31419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:90938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OPLAH
Gene Tree: Oplah

Human
homologs
OPLAH, 5-oxoprolinase (ATP-hydrolysing)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 26873
neXtProt AC: NX_O14841

Human Synonyms: 5-Opase, OPLA, OPLAHD

Human Chr (Location): 8q24.3; chr8:144051266-144064026 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human OPLAH

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Radiation induced(1) Targeted(3)
Genomic Mutations involving Oplah (1)
Incidental mutations (data from Mutagenetix , APF )
Phenotype Images(2)
Interactions
Oplah interacts with 15 markers (Mir30b, Mir134, Mir324, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process glutathione metabolic process
Component cellular_component
Function 5-oxoprolinase (ATP-hydrolyzing) activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase oplah    NEW 
Molecular
reagents
All nucleic(63) cDNA(63)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035743 (Evidence)
Ensembl Gene Model ENSMUSG00000022562 (Evidence)
Entrez Gene 75475 (Evidence)
UniGene 322738
DFCI TC1578405
NIA Mouse Gene Index U036338
EC 3.5.2.9
Consensus CDS Project CCDS27565.1
International Mouse Phenotyping Consortium Status Oplah
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035743 VEGA Gene Model | MGI Sequence Detail 31419 C57BL/6J ±  kb
transcript OTTMUST00000091387 VEGA | MGI Sequence Detail 4085 Not Applicable 
polypeptide OTTMUSP00000050341 VEGA | MGI Sequence Detail 1288 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(9) UniProt(5)
Polymorphisms
SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003692 Hydantoinase B/oxoprolinase
InterPro IPR002821 Hydantoinase/oxoprolinase
InterPro IPR008040 Hydantoinaseoxoprolinase, N-terminal
Protein Ontology PR:000011649 5-oxoprolinase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory