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Wdr35
Gene Detail
Symbol

Name
ID
Wdr35
WD repeat domain 35
MGI:1921932
Synonyms
4930459M12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
3.97 cM, cytoband A1.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:8973892-9028847 bp, + strand
From VEGA annotation of GRCm38

  54956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: WD repeat protein 35
Gene Tree: Wdr35

Human
homologs
Human Homolog WDR35, WD repeat domain 35
NCBI Gene ID 57539
neXtProt AC  NX_Q9P2L0
Human Synonyms  CED2, IFT121, IFTA1, SRTD7
Human Chr (Location)  2p24.1; chr2:19910263-19990123 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human WDR35
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU induced mutation exhibit mid-gestation lethality, heart development defects, turning defects, polysyndactyly, hypoplastic lungs, tracheoesophageal fistula, herniated diaphragm and absent embryonic cilia.
 
Human Diseases Modeled Using Mouse Wdr35 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Wdr35 interacts with 296 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell projection organization, cilium assembly, ...
Component axoneme, cell, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) cDNA(63)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027013 (Evidence)
Ensembl Gene ModelENSMUSG00000066643 (Evidence)
Entrez Gene74682 (Evidence)
UniGene87389
DFCITC1577769, TC1591762
DoTSDT.101155227, DT.60106159, DT.91436648
NIA Mouse Gene IndexU013748
Consensus CDS ProjectCCDS25807.1, CCDS49027.1
International Mouse Knockout Project StatusWdr35
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027013 VEGA Gene Model | MGI Sequence Detail 54956 C57BL/6J ±  kb
transcript OTTMUST00000066781 VEGA | MGI Sequence Detail 4501 Not Applicable 
polypeptide OTTMUSP00000033516 VEGA | MGI Sequence Detail 1181 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
InterPro IPR017233 WD repeat protein 35
Protein Ontology PR:000031069 WD repeat-containing protein 35
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(32)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory