F13a1
Gene Detail

Symbol Name ID

F13a1 coagulation factor XIII, A1 subunit MGI:1921395

Synonyms

1200014I03Rik, Factor XIIIA

Feature Type

protein coding gene

Genetic Map

Chromosome 13

14.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:36867178-37050244 bp, - strand From NCBI annotation of GRCm38   183067 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TGM_EBP42
Gene Tree: F13a1

Human homologs

Human Homolog		F13A1, coagulation factor XIII, A1 polypeptide
NCBI Gene ID		2162
neXtProt AC		NX_P00488
Human Synonyms		F13A
Human Chr (Location)		6p25.3-p24.3; chr6:6144311-6320924 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human F13A1

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous mutant mice exhibit bleeding symptoms, increased lethality, and impaired fertility.

 
Human Diseases Modeled Using Mouse F13a1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	blood coagulation, hemostasis, ...
Component	cytoplasm, extracellular region
Function	metal ion binding, protein-glutamine gamma-glutamyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (97)    Tissues (95)    Images (6)
Theiler Stages: 22, 26

Assay Type	Results
Immunohistochemistry	3
RNA in situ	94

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(63) cDNA(63)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000039109 (Evidence)
Entrez Gene	74145 (Evidence)
UniGene	235105
DFCI	TC1575865, TC1609482, TC1761399
DoTS	DT.101354119, DT.101371012, DT.101734866, DT.87028181, DT.91335215, DT.91402718
NIA Mouse Gene Index	U034690
EC	2.3.2.13
Consensus CDS Project	CCDS26456.1
International Mouse Knockout Project Status	F13a1

Sequences

Length	Strain/Species
genomic	74145	NCBI Gene Model | MGI Sequence Detail	183067	C57BL/6J
transcript	NM_028784	RefSeq | MGI Sequence Detail	3879	Not Specified
polypeptide	Q8BH61	UniProt | EBI | MGI Sequence Detail	732	Not Applicable

All sequences(44) RefSeq(4) UniProt(7)

Polymorphisms

SNPs(1144 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR023608	Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro	IPR013808	Transglutaminase, conserved site
InterPro	IPR008958	Transglutaminase, C-terminal
InterPro	IPR002931	Transglutaminase-like
InterPro	IPR001102	Transglutaminase, N-terminal
InterPro	IPR000738	WHEP-TRS
Protein Ontology	PR:000007297	coagulation factor XIII A chain

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(39)

Other accession IDs

MGI:2145250