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F13a1
Gene Detail
Symbol

Name
ID
F13a1
coagulation factor XIII, A1 subunit
MGI:1921395
Synonyms
1200014I03Rik, Factor XIIIA
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:36867178-37050244 bp, - strand
From NCBI annotation of GRCm38

  183067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: F13A1
Protein SuperFamily: TGM_EBP42
Gene Tree: F13a1

Human
homologs
F13A1, coagulation factor XIII, A1 polypeptide
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2162
neXtProt AC: NX_P00488

Human Synonyms: F13A

Human Chr (Location): 6p25.3-p24.3; chr6:6144078-6321013 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human F13A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice exhibit bleeding symptoms, increased lethality, and impaired fertility.
 
Human Diseases Modeled in Mice Using F13a1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
F13a1 interacts with 260 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process blood coagulation, hemostasis, ...
Component blood microparticle, cytoplasm, ...
Function metal ion binding, protein-glutamine gamma-glutamyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (97)    Tissues (95)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 94
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase f13a1 ; ZFIN f13a1a.1    NEW 
Molecular
reagents
All nucleic(64) cDNA(64)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000039109 (Evidence)
Entrez Gene 74145 (Evidence)
UniGene 235105
DFCI TC1761399, TC1609482, TC1575865
DoTS DT.87028181, DT.101734866, DT.101371012, DT.101354119, DT.91335215, DT.91402718
NIA Mouse Gene Index U034690
EC 2.3.2.13
Consensus CDS Project CCDS26456.1
International Mouse Phenotyping Consortium Status F13a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74145 NCBI Gene Model | MGI Sequence Detail 183067 C57BL/6J ±  kb
transcript NM_028784 RefSeq | MGI Sequence Detail 3879 Not Specified 
polypeptide Q8BH61 UniProt | EBI | MGI Sequence Detail 732 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(1213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
InterPro IPR000738 WHEP-TRS
Protein Ontology PR:000007297 coagulation factor XIII A chain
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:221213 Raghu H, et al., Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. Blood. 2015 Jan 15;125(3):427-37
All references(43)
Disease annotation references (2)
Other
accession IDs
MGI:2145250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory