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Atl1
Gene Detail
 Symbol
Name
ID
Atl1
atlastin GTPase 1
MGI:1921241
Synonyms AD-FSP, FSP1, SPG3, Spg3a
Feature Type protein coding gene
Genetic Map
Chromosome 12
28.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:69893105-69964085 bp, + strand
From NCBI annotation of GRCm38

  70981 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Atl1

Human
homologs
Human Homolog ATL1, atlastin GTPase 1
NCBI Gene ID 51062
neXtProt AC  NX_Q8WXF7
Human Synonyms  AD-FSP, atlastin1, FSP1, GBP3, HSN1D, SPG3, SPG3A
Human Chr (Location)  14q22.1; chr14:50533082-50633068 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ATL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from APF )
 
Homozygous animals show a gait disturbance characterized by external rotation of the hind feet with footprint analysis.
 
Interactions
Atl1 interacts with 215 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process axonogenesis, endoplasmic reticulum organization, ...
Component cell projection, endoplasmic reticulum, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021066 (Evidence)
Entrez Gene73991 (Evidence)
DFCITC1576534, TC1594678, TC1618022, TC1635258, TC1732908
NIA Mouse Gene IndexU014035
EC3.6.5.-
Consensus CDS ProjectCCDS36465.1
International Mouse Knockout Project StatusAtl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 73991 NCBI Gene Model | MGI Sequence Detail 70981 C57BL/6J ±  kb
transcript NM_178628 RefSeq | MGI Sequence Detail 2818 C57BL/6 
polypeptide Q8BH66 UniProt | EBI | MGI Sequence Detail 558 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(287 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003191 Guanylate-binding protein, C-terminal
InterPro IPR015894 Guanylate-binding protein, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000004424 atlastin-1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204528 Gao Y, et al., Atlastin-1 regulates dendritic morphogenesis in mouse cerebral cortex. Neurosci Res. 2013 Nov;77(3):137-42
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory