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Cby1
Gene Detail
 Symbol
Name
ID
Cby1
chibby homolog 1 (Drosophila)
MGI:1920989
Synonyms 1110014P06Rik, arb1, Pgea1, PGEA14
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.84 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:79659227-79667660 bp, + strand
From NCBI annotation of GRCm38

  8434 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cby1

Human
homologs
Human Homolog CBY1, chibby homolog 1 (Drosophila)
NCBI Gene ID 25776
neXtProt AC  NX_Q9Y3M2
Human Synonyms  arb1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA14, PIGEA-14
Human Chr (Location)  22q12; chr22:38656653-38673850 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Radiation induced(1) Targeted(3)
Genomic Mutations involving Cby1 (1)
 
Most homozygous null mice are anemic and runted and die around weaning. Survivors develop sinusitis and otitis due to lack of mucociliary transport and a paucity of airway cilia. Adult lungs show enlarged alveoli, reduced proliferation, epithelial cell dysmorphology and reduced pulmonary function.
 
Human Diseases Modeled Using Mouse Cby1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Cby1 interacts with 60 markers (Mir22, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cardiac muscle cell differentiation, cell differentiation, ...
Component ciliary basal body, Golgi apparatus, ...
Function beta-catenin binding, identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (16)    Tissues (7)    Images (10)
Theiler Stages: 20, 23, 28
Assay TypeResults
RNA in situ 10
RT-PCR 6
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(41) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022428 (Evidence)
Entrez Gene73739 (Evidence)
UniGene294441
DFCITC1579864
DoTSDT.492010
NIA Mouse Gene IndexU016430
Consensus CDS ProjectCCDS27645.1
International Mouse Knockout Project StatusCby1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 73739 NCBI Gene Model | MGI Sequence Detail 8434 C57BL/6J ±  kb
transcript NM_028634 RefSeq | MGI Sequence Detail 1119 C57BL/6 
polypeptide Q9D1C2 UniProt | EBI | MGI Sequence Detail 127 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000005090 protein chibby homolog 1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189887 Steere N, et al., A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation. PLoS One. 2012;7(7):e41077
All references(37)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory