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Cby1
Gene Detail
Symbol

Name
ID
Cby1
chibby homolog 1 (Drosophila)
MGI:1920989
Synonyms
1110014P06Rik, arb1, Pgea1, PGEA14
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.84 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:79659227-79667660 bp, + strand
From Ensembl annotation of GRCm38

  8434 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CBY1
Gene Tree: Cby1

Human
homologs
CBY1, chibby homolog 1 (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 25776
neXtProt AC: NX_Q9Y3M2

Human Synonyms: arb1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA14, PIGEA-14

Human Chr (Location): 22q12; chr22:38656653-38673850 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Radiation induced(1) Targeted(3)
Genomic Mutations involving Cby1 (1)
 
Most homozygous null mice are anemic and runted and die around weaning. Survivors develop sinusitis and otitis due to lack of mucociliary transport and a paucity of airway cilia. Adult lungs show enlarged alveoli, reduced proliferation, epithelial cell dysmorphology and reduced pulmonary function.
 
Human Diseases Modeled in Mice Using Cby1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Cby1 interacts with 60 markers (Mir22, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cardiac muscle cell differentiation, cell differentiation, ...
Component ciliary basal body, Golgi apparatus, ...
Function beta-catenin binding, identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (16)    Tissues (7)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
RT-PCR 6
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cby1    NEW 
Molecular
reagents
All nucleic(42) cDNA(41) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022428 (Evidence)
Entrez Gene 73739 (Evidence)
UniGene 294441
DFCI TC1579864
DoTS DT.492010
NIA Mouse Gene Index U016430
Consensus CDS Project CCDS27645.1
International Mouse Phenotyping Consortium Status Cby1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022428 Ensembl Gene Model | MGI Sequence Detail 8434 C57BL/6J ±  kb
transcript ENSMUST00000023064 Ensembl | MGI Sequence Detail 1119 Not Applicable 
polypeptide ENSMUSP00000023064 Ensembl | MGI Sequence Detail 127 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028118 Chibby family
Protein Ontology PR:000005090 protein chibby homolog 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189887 Steere N, et al., A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation. PLoS One. 2012;7(7):e41077
All references(36)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory