Cby1
Gene Detail

Symbol Name ID

Cby1 chibby homolog 1 (Drosophila) MGI:1920989

Synonyms

1110014P06Rik, arb1, Pgea1, PGEA14

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.84 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:79659227-79667660 bp, + strand From NCBI annotation of GRCm38   8434 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cby1

Human homologs

Human Homolog		CBY1, chibby homolog 1 (Drosophila)
NCBI Gene ID		25776
neXtProt AC		NX_Q9Y3M2
Human Synonyms		arb1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA14, PIGEA-14
Human Chr (Location)		22q12; chr22:39052658-39069855 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(3) Gene trapped(9)
 

Most homozygous null mice are anemic and runted and die around weaning. Survivors develop sinusitis and otitis due to lack of mucociliary transport and a paucity of airway cilia. Adult lungs show enlarged alveoli, reduced proliferation, epithelial cell dysmorphology and reduced pulmonary function.

 
Human Diseases Modeled Using Mouse Cby1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cardiac muscle cell differentiation, cell differentiation, ...
Component	Golgi apparatus, microtubule basal body, ...
Function	beta-catenin binding, identical protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (16)    Tissues (7)    Images (10)
Theiler Stages: 20, 23, 28

Assay Type	Results
RNA in situ	10
RT-PCR	6

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(41) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022428 (Evidence)
Entrez Gene	73739 (Evidence)
UniGene	294441
DFCI	TC1579864
DoTS	DT.492010
NIA Mouse Gene Index	U016430
Consensus CDS Project	CCDS27645.1
International Mouse Knockout Project Status	Cby1

Sequences

Length	Strain/Species
genomic	73739	NCBI Gene Model | MGI Sequence Detail	8434	C57BL/6J
transcript	NM_028634	RefSeq | MGI Sequence Detail	1119	C57BL/6
polypeptide	Q9D1C2	UniProt | EBI | MGI Sequence Detail	127	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000005090	protein chibby 1

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189887 Steere N, et al., A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation. PLoS One. 2012;7(7):e41077
All references(37)