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Megf11 Gene Detail
Summary
  • Symbol
    Megf11
  • Name
    multiple EGF-like-domains 11
  • Synonyms
    2410080H04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920951
    NCBI Gene: 214058
Location & Maps
more
  • Sequence Map
    Chr9:64385626-64709205 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      323580 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 34.67 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MEGF11, multiple EGF like domains 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MEGF11, multiple EGF like domains 11
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84465
    neXtProt AC: NX_A6BM72

  • Chr Location
    15q22.31; chr15:65895296-66253737 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Targeted
    2
  • Genomic Mutations
    1 involving Megf11
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit abnormal spacing of horizontal cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031743 VEGA Gene Model | MGI Sequence Detail 323580 C57BL/6J ±  kb
transcript OTTMUST00000078620 VEGA | MGI Sequence Detail 6680 Not Applicable  
polypeptide OTTMUSP00000041836 VEGA | MGI Sequence Detail 1091 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1728 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:182578 Kay JN, et al., MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Nature. 2012 Mar 22;483(7390):465-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory