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Cul4b
Gene Detail
Symbol

Name
ID
Cul4b
cullin 4B
MGI:1919834
Synonyms
2700050M05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome X
22.81 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:38533274-38576196 bp, - strand
From VEGA annotation of GRCm38

  42923 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2660  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CUL4B
Protein SuperFamily: cullin
Gene Tree: Cul4b

Human
homologs
CUL4B, cullin 4B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8450
neXtProt AC: NX_Q13620

Human Synonyms: CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2

Human Chr (Location): Xq23; chrX:120524589-120575829 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CUL4B

Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(66) Targeted(6)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a conditional allele activated in the brain exhibit impaired spatial learning and memory, increased susceptibility to PTZ-induced seizures, abnormal dendrite morphology on hippocampal neurons. Mice homozygous for a null allele exhibit embryonic lethality and abnormal placenta.
 
Phenotype Images(4)
Interactions
Cul4b interacts with 292 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cul4b ; ZFIN cul4b    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017236 (Evidence)
Ensembl Gene Model ENSMUSG00000031095 (Evidence)
Entrez Gene 72584 (Evidence)
DFCI TC1658182, TC1610395, TC1608479, TC1574053
DoTS DT.99857535, DT.97334745, DT.101365038, DT.491158, DT.111020224
Consensus CDS Project CCDS40948.1
International Mouse Phenotyping Consortium Status Cul4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017236 VEGA Gene Model | MGI Sequence Detail 42923 C57BL/6J ±  kb
transcript OTTMUST00000089886 VEGA | MGI Sequence Detail 3090 Not Applicable 
polypeptide OTTMUSP00000049168 VEGA | MGI Sequence Detail 970 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR019559 Cullin protein, neddylation domain
InterPro IPR016159 Cullin repeat-like-containing domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006050 cullin-4B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(52)
Other
accession IDs
MGI:3034471

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory