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Cul4b
Gene Detail
 Symbol
Name
ID
Cul4b
cullin 4B
MGI:1919834
Synonyms 2700050M05Rik
Feature Type protein coding gene
Genetic Map
Chromosome X
22.81 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:38533274-38576196 bp, - strand
From VEGA annotation of GRCm38

  42923 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2660  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cullin
Gene Tree: Cul4b

Human
homologs
Human Homolog CUL4B, cullin 4B
NCBI Gene ID 8450
neXtProt AC  NX_Q13620
Human Synonyms  CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
Human Chr (Location)  Xq23; chrX:120524589-120575829 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CUL4B
Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(66) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for a conditional allele activated in the brain exhibit impaired spatial learning and memory, increased susceptibility to PTZ-induced seizures, abnormal dendrite morphology on hippocampal neurons. Mice homozygous for a null allele exhibit embryonic lethality and abnormal placenta.
 
Phenotype Images(4)
Interactions
Cul4b interacts with 292 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component Cul4B-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, ...
Function damaged DNA binding, ubiquitin protein ligase binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017236 (Evidence)
Ensembl Gene ModelENSMUSG00000031095 (Evidence)
Entrez Gene72584 (Evidence)
DFCITC1574053, TC1608479, TC1610395, TC1658182
DoTSDT.101365038, DT.111020224, DT.491158, DT.97334745, DT.99857535
Consensus CDS ProjectCCDS40948.1
International Mouse Knockout Project StatusCul4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017236 VEGA Gene Model | MGI Sequence Detail 42923 C57BL/6J ±  kb
transcript OTTMUST00000041721 VEGA | MGI Sequence Detail 3344 Not Applicable 
polypeptide OTTMUSP00000018749 VEGA | MGI Sequence Detail 970 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR019559 Cullin protein, neddylation domain
InterPro IPR016159 Cullin repeat-like-containing domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006050 cullin-4B
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(50)
Other
accession IDs
MGI:3034471

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory