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Cul4b Gene Detail
Summary
  • Symbol
    Cul4b
  • Name
    cullin 4B
  • Synonyms
    2700050M05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919834
    NCBI Gene: 72584
  • Gene Overview
    MyGene.info: CUL4B
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:38533274-38576196 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 22.81 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919834
protein coding gene ChrX:38531616-38576196 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035666
protein coding gene ChrX:33499278-33545335 (-)
A/J MGP_AJ_G0035651
protein coding gene ChrX:33555221-33598127 (-)
AKR/J MGP_AKRJ_G0035568
protein coding gene ChrX:34335685-34391106 (-)
BALB/cJ MGP_BALBcJ_G0035635
protein coding gene ChrX:33259330-33303111 (-)
C3H/HeJ MGP_C3HHeJ_G0035339
protein coding gene ChrX:33866591-33910976 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036166
protein coding gene ChrX:34252749-34315020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033018
protein coding gene ChrX:31966801-32010090 (-)
CAST/EiJ MGP_CASTEiJ_G0034630
protein coding gene ChrX:21865737-21920844 (-)
CBA/J MGP_CBAJ_G0035313
protein coding gene ChrX:35136964-35184255 (-)
DBA/2J MGP_DBA2J_G0035467
protein coding gene ChrX:33388534-33436907 (-)
FVB/NJ MGP_FVBNJ_G0035416
protein coding gene ChrX:33143345-33185312 (-)
LP/J MGP_LPJ_G0035555
protein coding gene ChrX:33900604-33947132 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035454
protein coding gene ChrX:35461961-35528704 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036182
protein coding gene ChrX:33546770-33589678 (-)
PWK/PhJ MGP_PWKPhJ_G0034331
protein coding gene ChrX:21445328-21487237 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034176
protein coding gene ChrX:22396426-22448284 (-)
WSB/EiJ MGP_WSBEiJ_G0034776
protein coding gene ChrX:33229715-33273115 (-)



Homology
more
  • Human Ortholog
    CUL4B, cullin 4B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CUL4B, cullin 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
  • Links
    NCBI Gene ID: 8450
    neXtProt AC: NX_Q13620
    UniProt: Q13620

  • Chr Location
    Xq24; chrX:120524589-120575829 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cul4b mouse models; 1 with human CUL4B associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 7 genetic backgrounds
    8 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the brain exhibit impaired spatial learning and memory, increased susceptibility to PTZ-induced seizures, abnormal dendrite morphology on hippocampal neurons. Mice homozygous for a null allele exhibitembryonic lethality and abnormal placenta.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031095 Ensembl Gene Model | MGI Sequence Detail 42923 C57BL/6J ±  kb
    transcript ENSMUST00000050083 Ensembl | MGI Sequence Detail 3090 Not Applicable  
    polypeptide ENSMUSP00000059276 Ensembl | MGI Sequence Detail 970 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3034471
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:254519 Li G, et al., CRL4(DCAF8) Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell Rep. 2017 Feb 7;18(6):1499-1511

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory