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Zc3h14 Gene Detail
Summary
  • Symbol
    Zc3h14
  • Name
    zinc finger CCCH type containing 14
  • Synonyms
    1010001P15Rik, 1700016A15Rik, 2700069A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919824
    NCBI Gene: 75553
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:98746964-98787753 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 49.88 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919824
protein coding gene Chr12:98746964-98787774 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020008
protein coding gene Chr12:100149751-100191817 (+)
A/J MGP_AJ_G0019963
protein coding gene Chr12:96382887-96425149 (+)
AKR/J MGP_AKRJ_G0019939
protein coding gene Chr12:98989317-99030125 (+)
BALB/cJ MGP_BALBcJ_G0019949
protein coding gene Chr12:96715752-96757249 (+)
C3H/HeJ MGP_C3HHeJ_G0019751
protein coding gene Chr12:99540846-99581656 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020398
protein coding gene Chr12:103196581-103238379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018012
protein coding gene Chr12:93352759-93392094 (+)
CAST/EiJ MGP_CASTEiJ_G0019297
protein coding gene Chr12:94589239-94633758 (+)
CBA/J MGP_CBAJ_G0019723
protein coding gene Chr12:107032846-107078933 (+)
DBA/2J MGP_DBA2J_G0019834
protein coding gene Chr12:95807733-95849813 (+)
FVB/NJ MGP_FVBNJ_G0019823
protein coding gene Chr12:94527084-94568274 (+)
LP/J MGP_LPJ_G0019910
protein coding gene Chr12:99977913-100019881 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019865
protein coding gene Chr12:110710331-110753655 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020427
protein coding gene Chr12:98554014-98596127 (+)
PWK/PhJ MGP_PWKPhJ_G0019061
protein coding gene Chr12:90423215-90464878 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018857
protein coding gene Chr12:92715640-92758103 (+)
WSB/EiJ MGP_WSBEiJ_G0019351
protein coding gene Chr12:99385985-99428004 (+)



Homology
more
  • Human Ortholog
    ZC3H14, zinc finger CCCH-type containing 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZC3H14, zinc finger CCCH-type containing 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRT56, MSUT-2, NY-REN-37, SUT2, UKp68
  • Links
    NCBI Gene ID: 79882
    neXtProt AC: NX_Q6PJT7
    UniProt: Q6PJT7

  • Chr Location
    14q31.3; chr14:88562909-88614720 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32605
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZC3H14
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout results in impaired spatial working memory, enlarged anterior lateral ventricles in the brain, small testes and reduced litter size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021012 Ensembl Gene Model | MGI Sequence Detail 40790 C57BL/6J ±  kb
    transcript ENSMUST00000110105 Ensembl | MGI Sequence Detail 3514 Not Applicable  
    polypeptide ENSMUSP00000105732 Ensembl | MGI Sequence Detail 735 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 14
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915653, MGI:1922803, MGI:2144932
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:249492 Rha J, et al., The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Hum Mol Genet. 2017 Oct 01;26(19):3663-3681

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/09/2019
    MGI 6.14
    The Jackson Laboratory