About   Help   FAQ
Zc3h14 Gene Detail
Summary
  • Symbol
    Zc3h14
  • Name
    zinc finger CCCH type containing 14
  • Synonyms
    1010001P15Rik, 1700016A15Rik, 2700069A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919824
    NCBI Gene: 75553
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:98746964-98787753 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40790 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 49.88 cM, cytoband F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ZC3H14, zinc finger CCCH-type containing 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZC3H14, zinc finger CCCH-type containing 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRT56, MSUT-2, NY-REN-37, SUT2, UKp68
  • Links
    NCBI Gene ID: 79882
    neXtProt AC: NX_Q6PJT7
    UniProt: Q6PJT7

  • Chr Location
    14q31.3; chr14:88562909-88614720 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32605
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZC3H14
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in impaired spatial working memory, enlarged anterior lateral ventricles in the brain, small testes and reduced litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021012 Ensembl Gene Model | MGI Sequence Detail 40790 C57BL/6J ±  kb
    transcript ENSMUST00000110105 Ensembl | MGI Sequence Detail 3514 Not Applicable  
    polypeptide ENSMUSP00000105732 Ensembl | MGI Sequence Detail 735 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      180 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915653, MGI:1922803, MGI:2144932
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:249492 Rha J, et al., The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Hum Mol Genet. 2017 Oct 01;26(19):3663-3681

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory