Uaca
Gene Detail

Symbol Name ID

Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats MGI:1919815

Synonyms

2700059D02Rik, nucling

Feature Type

protein coding gene

Genetic Map

Chromosome 9

32.93 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:60794548-60880370 bp, + strand From NCBI annotation of GRCm38   85823 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74297  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Uaca

Human homologs

Human Homolog		UACA, uveal autoantigen with coiled-coil domains and ankyrin repeats
NCBI Gene ID		55075
neXtProt AC		NX_Q9BZF9
Human Synonyms		NUCLING
Human Chr (Location)		15q22-q24; chr15:70946893-71055850 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(12)
 

Homozygous mice display swelling of and inflammatory lesions in the preputial gland.

 
Human Diseases Modeled Using Mouse Uaca (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to oxidative stress, ...
Component	apoptosome, cytoplasm, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (15)    Tissues (15)    Images (1)
Theiler Stages: 10, 15, 17, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	3
Northern blot	12

cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) cDNA(87)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000034485 (Evidence)
Entrez Gene	72565 (Evidence)
UniGene	68819
DFCI	TC1577513, TC1591662
DoTS	DT.103560283, DT.490153, DT.55157941, DT.97365079
NIA Mouse Gene Index	U010589
Consensus CDS Project	CCDS23259.1
International Mouse Knockout Project Status	Uaca

Sequences

Length	Strain/Species
genomic	72565	NCBI Gene Model | MGI Sequence Detail	85823	C57BL/6J
transcript	NM_028283	RefSeq | MGI Sequence Detail	4428	C57BL/6
polypeptide	Q8CGB3	UniProt | EBI | MGI Sequence Detail	1411	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(443 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR000727	Target SNARE coiled-coil domain
Protein Ontology	PR:000016947	uveal autoantigen with coiled-coil domains and ankyrin repeats

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:157049 Sakai T, et al., Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. Int J Cancer. 2010 Mar 1;126(5):1079-94
All references(38)