About   Help   FAQ
Kcnk10 Gene Detail
Summary
  • Symbol
    Kcnk10
  • Name
    potassium channel, subfamily K, member 10
  • Synonyms
    1700024D23Rik, 3010005K24Rik, Trek2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919508
    NCBI Gene: 72258
  • Gene Overview
    MyGene.info: KCNK10
Location & Maps
more
  • Sequence Map
    Chr12:98433994-98577940 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      143947 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 49.86 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KCNK10, potassium two pore domain channel subfamily K member 10
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KCNK10, potassium two pore domain channel subfamily K member 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    K2p10.1, PPP1R97, TREK2, TREK-2
  • Links
    NCBI Gene ID: 54207
    neXtProt AC: NX_P57789

  • Chr Location
    14q31.3; chr14:88180108-88326912 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Kcnk10
  • Incidental Mutations
Mice homozygous for a null allele exhibit normal glucose hyperpolarization of hypothalamic neurons in response to glucose.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033854 Ensembl Gene Model | MGI Sequence Detail 143947 C57BL/6J ±  kb
transcript ENSMUST00000110113 Ensembl | MGI Sequence Detail 2533 Not Applicable  
polypeptide ENSMUSP00000105740 Ensembl | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1068 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR003280 Two pore domain potassium channel
    IPR003976 Two pore domain potassium channel, TREK
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1924704
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232118 Blin S, et al., Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4200-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory