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Ercc8
Gene Detail
 Symbol
Name
ID
Ercc8
excision repaiross-complementing rodent repair deficiency, complementation group 8
MGI:1919241
Synonyms 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, B130065P18Rik, Ckn1, Csa
Feature Type protein coding gene
Genetic Map
Chromosome 13
59.69 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:108158731-108195364 bp, + strand
From VEGA annotation of GRCm38

  36634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ercc8

Human
homologs
Human Homolog ERCC8, excision repair cross-complementation group 8
NCBI Gene ID 1161
neXtProt AC  NX_Q13216
Human Synonyms  CKN1, CSA, UVSS2
Human Chr (Location)  5q12.1; chr5:60873832-60945078 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ERCC8
Alleles
and
phenotypes
All alleles(9) : Targeted(2) Gene trapped(7)
 
Homozygous mutation of this gene results in skin photosensitivity, increased incidence of skin tumors after UV exposure, and progressive photoreceptor degeneration.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component Cul4A-RING ubiquitin ligase complex, nuclear matrix, ...
Function protein complex binding, ubiquitin-protein ligase activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) Genomic(1) cDNA(45)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030543 (Evidence)
Ensembl Gene ModelENSMUSG00000021694 (Evidence)
Entrez Gene71991 (Evidence)
UniGene212208
DFCITC1579821, TC1585637, TC1597480, TC1606738, TC1642406, TC1678686, TC1698041
DoTSDT.101308991, DT.486385, DT.91376246, DT.94199507, DT.94199514, DT.99851633
NIA Mouse Gene IndexU043369, U361689
Consensus CDS ProjectCCDS26761.1
International Mouse Knockout Project StatusErcc8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030543 VEGA Gene Model | MGI Sequence Detail 36634 C57BL/6J ±  kb
transcript OTTMUST00000075602 VEGA | MGI Sequence Detail 2111 Not Applicable 
polypeptide OTTMUSP00000039667 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(6) UniProt(9)
Polymorphisms SNPs within 2kb(256 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000007170 DNA excision repair protein ERCC-8
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:179808 Jaarsma D, et al., Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet. 2011 Dec;7(12):e1002405
All references(43)
Other
accession IDs
MGI:1917208, MGI:1924296, MGI:2443311

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory