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Esco2 Gene Detail
Summary
  • Symbol
    Esco2
  • Name
    establishment of sister chromatid cohesion N-acetyltransferase 2
  • Synonyms
    2410004I17Rik, D030072L07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919238
    NCBI Gene: 71988
  • Gene Overview
    MyGene.info: ESCO2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:65819027-65833969 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.36 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919238
protein coding gene Chr14:65819027-65833994 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021485
protein coding gene Chr14:60452815-60467770 (-)
A/J MGP_AJ_G0021444
protein coding gene Chr14:59041121-59056011 (-)
AKR/J MGP_AKRJ_G0021420
protein coding gene Chr14:61090315-61106259 (-)
BALB/cJ MGP_BALBcJ_G0021450
protein coding gene Chr14:58984911-59000064 (-)
C3H/HeJ MGP_C3HHeJ_G0021227
protein coding gene Chr14:60747232-60762133 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021889
protein coding gene Chr14:63239428-63256488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019429
protein coding gene Chr14:56968088-56983747 (-)
CAST/EiJ MGP_CASTEiJ_G0020744
protein coding gene Chr14:57242740-57257720 (-)
CBA/J MGP_CBAJ_G0021194
protein coding gene Chr14:65164174-65179128 (-)
DBA/2J MGP_DBA2J_G0021317
protein coding gene Chr14:58690247-58705197 (-)
FVB/NJ MGP_FVBNJ_G0021296
protein coding gene Chr14:58098959-58114054 (-)
LP/J MGP_LPJ_G0021392
protein coding gene Chr14:61496656-61512024 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021325
protein coding gene Chr14:64237422-64253677 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021912
protein coding gene Chr14:60292733-60308777 (-)
PWK/PhJ MGP_PWKPhJ_G0020488
protein coding gene Chr14:55414708-55429796 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020321
protein coding gene Chr14:56259596-56277577 (-)
WSB/EiJ MGP_WSBEiJ_G0020797
protein coding gene Chr14:60584913-60599865 (-)



Homology
more
  • Human Ortholog
    ESCO2, establishment of sister chromatid cohesion N-acetyltransferase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ESCO2, establishment of sister chromatid cohesion N-acetyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2410004I17Rik, EFO2, RBS
  • Links
    NCBI Gene ID: 157570
    neXtProt AC: NX_Q56NI9
    UniProt: Q56NI9

  • Chr Location
    8p21.1; chr8:27771949-27812404 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human ESCO2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation associated with impaired chromosome cohesion and abnormal mitosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71988 NCBI Gene Model | MGI Sequence Detail 14943 C57BL/6J ±  kb
    transcript NM_028039 RefSeq | MGI Sequence Detail 2899 C57BL/6  
    polypeptide Q8CIB9 UniProt | EBI | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 63
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2442869
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:246517 Lu Y, et al., Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis. Nucleic Acids Res. 2017 Sep 19;45(16):9388-9397

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory