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Esco2
Gene Detail
Symbol

Name
ID
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
MGI:1919238
Synonyms
2410004I17Rik, D030072L07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.36 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:65819038-65833994 bp, - strand
From VEGA annotation of GRCm38

  14957 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ESCO2
Gene Tree: Esco2

Human
homologs
ESCO2, establishment of sister chromatid cohesion N-acetyltransferase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 157570
neXtProt AC: NX_Q56NI9

Human Synonyms: 2410004I17Rik, EFO2, RBS

Human Chr (Location): 8p21.1; chr8:27771477-27812396 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ESCO2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation associated with impaired chromosome cohesion and abnormal mitosis.
 
Interactions
Esco2 interacts with 171 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (120)    Tissues (104)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 107
Northern blot 2
Western blot 2
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase esco2 ; ZFIN esco2    NEW 
Molecular
reagents
All nucleic(64) cDNA(62) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000024476 (Evidence)
Ensembl Gene Model ENSMUSG00000022034 (Evidence)
Entrez Gene 71988 (Evidence)
UniGene 249280
DFCI TC1575798
DoTS DT.481911, DT.55187123
NIA Mouse Gene Index U035695
EC 2.3.1.-
Consensus CDS Project CCDS27216.1
International Mouse Phenotyping Consortium Status Esco2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024476 VEGA Gene Model | MGI Sequence Detail 14957 C57BL/6J ±  kb
transcript OTTMUST00000060038 VEGA | MGI Sequence Detail 2913 Not Applicable 
polypeptide OTTMUSP00000029266 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028009 N-acetyltransferase ESCO, acetyl-transferase domain
InterPro IPR028005 N-acetyltransferase ESCO, zinc-finger
Protein Ontology PR:000007197 N-acetyltransferase ESCO2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(42)
Other
accession IDs
MGI:2442869

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory