Esco2 MGI Mouse Gene Detail - MGI:1919238 - establishment of sister chromatid cohesion N-acetyltransferase 2

Symbol

Esco2
Name

establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms

2410004I17Rik, D030072L07Rik

Feature Type

protein coding gene
IDs

MGI:1919238
NCBI Gene: 71988
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:66056476-66071418 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.36 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

367 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919238	protein coding gene	Chr14:66056476-66071443 (-)
129S1/SvImJ	ENSMUSG00200026294	protein coding gene	Chr14:54657011-54671963 (-)
A/J	ENSMUSG00195012751	protein coding gene	Chr14:54834437-54849395 (-)
AKR/J	ENSMUSG00220031698	protein coding gene	Chr14:54174932-54189889 (-)
BALB/cJ	ENSMUSG00180034073	protein coding gene	Chr14:54450609-54465567 (-)
C3H/HeJ	ENSMUSG00175031825	protein coding gene	Chr14:56193408-56208361 (-)
C57BL/6NJ	ENSMUSG00215017720	protein coding gene	Chr14:54389433-54404391 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019429	protein coding gene	Chr14:56968088-56983747 (-)
CAST/EiJ	ENSTCUG00005034645	protein coding gene	Chr14:56095018-56109998 (-)
CBA/J	ENSMUSG00210033463	protein coding gene	Chr14:54821779-54836736 (-)
DBA/2J	ENSMUSG00185031054	protein coding gene	Chr14:59991241-60006194 (-)
FVB/NJ	ENSMUSG00205027559	protein coding gene	Chr14:54337255-54352212 (-)
JF1/MsJ	ENSUMUG00000027107	protein coding gene	Chr14:71164507-71179429 (-)
LP/J	ENSMUSG00230032934	protein coding gene	Chr14:72020528-72035481 (-)
NOD/ShiLtJ	ENSMUSG00190026245	protein coding gene	Chr14:54616495-54631452 (-)
NZO/HlLtJ	ENSMUSG00225039693	protein coding gene	Chr14:62349395-62364352 (-)
PWK/PhJ	ENSLUMG00010034207	protein coding gene	Chr14:54049324-54064342 (-)
SPRET/EiJ	ENSMSPG00010028162	protein coding gene	Chr14:57546732-57562467 (-)
WSB/EiJ	ENSIUOG00005038850	protein coding gene	Chr14:54053119-54068076 (-)

Human Ortholog

ESCO2, establishment of sister chromatid cohesion N-acetyltransferase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ESCO2, establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms

2410004I17Rik, EFO2, EFO2p, hEFO2, JHS, RBS
Links

HGNC:27230

NCBI Gene ID: 157570

UniProt: Q56NI9
Chr Location

8p21.1; chr8:27771949-27819660 (+) GRCh38

MGI Vertebrate Homology

Esco2 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: ESCO2
Gene Tree

Esco2

Diseases

2 with human ESCO2 associations

				Human Disease	Mouse Models
				lung adenocarcinoma IDs lung adenocarcinoma DOID:3910 DOID:4826 EFO:0000571 MESH:D000077192 NCI:C27745 NCI:C3512 UMLS_CUI:C0152013 UMLS_CUI:C1335060
				Roberts syndrome IDs Roberts syndrome DOID:5325 MESH:C535687 NCI:C4681 OMIM:268300 ORDO:3103 UMLS_CUI:C0392475

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 2 alleles in 3 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

17
Targeted

8
Genomic Mutations

1 involving Esco2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation associated with impaired chromosome cohesion and abnormal mitosis.

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All GO Annotations

37
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

111
cDNA Data

63
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase esco2

ZFIN esco2

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All Sequences

49
RefSeq

2
UniProt

3
CCDS

CCDS27216.1

Ensembl

ENSMUSG00000022034 (Evidence)
NCBI Gene

71988

			Length	Strain/Species	Flank
genomic	71988	NCBI Gene Model \| MGI Sequence Detail	14943	C57BL/6J	± kb
transcript	NM_028039	RefSeq \| MGI Sequence Detail	2899	C57BL/6
polypeptide	Q8CIB9	UniProt \| EBI \| MGI Sequence Detail	592	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007197 N-acetyltransferase ESCO2

(term hierarchy)
PDB

6SP0
EC

2.3.1.-
InterPro Domains

IPR028009 N-acetyltransferase ESCO, acetyl-transferase domain

IPR028005 N-acetyltransferase ESCO, zinc-finger

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All nucleic 67

cDNA 63

Primer pair 2

Other 2

Antibodies 3

Microarray probesets 5

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MGI:2442869

Summaries

All 69

Developmental Gene Expression 10

Gene Ontology 10

Phenotypes 29
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:377785 Molina C, et al., Clonal expansion of alveolar fibroblast progeny drives pulmonary fibrosis in mouse models. J Clin Invest. 2025 Nov 17;135(22)

TSS for Esco2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129258	Chr14:66071412-66071423 (-)	0 bp
Tssr129257	Chr14:66071389-66071401 (-)	23 bp
Tssr129256	Chr14:66071361-66071380 (-)	47 bp
Tssr129255	Chr14:66071338-66071354 (-)	72 bp
Tssr129254	Chr14:66071300-66071315 (-)	110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24