Esco2
Gene Detail

Symbol Name ID

Esco2 establishment of cohesion 1 homolog 2 (S. cerevisiae) MGI:1919238

Synonyms

2410004I17Rik, D030072L07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 14

34.36 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:65819038-65833994 bp, - strand From VEGA annotation of GRCm38   14957 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Esco2

Human homologs

Human Homolog		ESCO2, establishment of sister chromatid cohesion N-acetyltransferase 2
NCBI Gene ID		157570
neXtProt AC		NX_Q56NI9
Human Synonyms		2410004I17Rik, EFO2, RBS
Human Chr (Location)		8p21.1; chr8:27632058-27662425 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(5) Gene trapped(18)
 

Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation associated with impaired chromosome cohesion and abnormal mitosis.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cell cycle, metabolic process, ...
Component	chromatin, chromosome, ...
Function	metal ion binding, transferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (120)    Tissues (104)    Images (18)
Theiler Stages: 22, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	107
Northern blot	2
Western blot	2

cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) cDNA(59) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000024476 (Evidence)
Ensembl Gene Model	ENSMUSG00000022034 (Evidence)
Entrez Gene	71988 (Evidence)
UniGene	249280
DFCI	TC1575798
DoTS	DT.481911, DT.55187123
NIA Mouse Gene Index	U035695
EC	2.3.1.-
Consensus CDS Project	CCDS27216.1
International Mouse Knockout Project Status	Esco2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024476	VEGA Gene Model | MGI Sequence Detail	14957	C57BL/6J
transcript	OTTMUST00000060038	VEGA | MGI Sequence Detail	2913	Not Applicable
polypeptide	OTTMUSP00000029266	VEGA | MGI Sequence Detail	592	Not Applicable

All sequences(35) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026656	N-acetyltransferase ESCO
Protein Ontology	PR:000007197	N-acetyltransferase ESCO2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192409 Evans EB, et al., Localization and regulation of murine Esco2 during male and female meiosis. Biol Reprod. 2012 Sep;87(3):61
All references(41)

Other accession IDs

MGI:2442869