Mus81
Gene Detail

Symbol Name ID

Mus81 MUS81 endonuclease homolog (yeast) MGI:1918961

Synonyms

1200008A18Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:5482345-5488402 bp, - strand From VEGA annotation of GRCm38   6058 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Mus81

Human homologs

Human Homolog		MUS81, MUS81 endonuclease homolog (S. cerevisiae)
NCBI Gene ID		80198
neXtProt AC		NX_Q96NY9
Human Synonyms		SLX3
Human Chr (Location)		11q13; chr11:65627872-65633914 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(7) Gene trapped(11)
 

Homozygous and heterozygous null mice for one allele display increased tumor incidence and reduced life spans. Homozygous null mice for a second allele display normal life span and tumor incidence.

 
Human Diseases Modeled Using Mouse Mus81 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	DNA metabolic process, DNA recombination, ...
Component	nucleus
Function	3'-flap endonuclease activity, catalytic activity, ...

External Resources: FuncBase

Expression

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) cDNA(41)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033940 (Evidence)
Ensembl Gene Model	ENSMUSG00000024906 (Evidence)
Entrez Gene	71711 (Evidence)
UniGene	27697
DFCI	TC1580842, TC1625148, TC1631122, TC1711136
DoTS	DT.101390217, DT.101390219, DT.110864611, DT.91374016, DT.94131700, DT.94131704, DT.94131708, DT.99846020, DT.99846022
NIA Mouse Gene Index	U019047
EC	3.1.22.-
PDB	2KP7
Consensus CDS Project	CCDS29467.1
International Mouse Knockout Project Status	Mus81

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033940	VEGA Gene Model | MGI Sequence Detail	6058	C57BL/6J
transcript	OTTMUST00000085631	VEGA | MGI Sequence Detail	2067	Not Applicable
polypeptide	OTTMUSP00000046281	VEGA | MGI Sequence Detail	551	Not Applicable

All sequences(66) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(36 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010996	DNA-directed DNA polymerase, family X, beta-like, N-terminal
InterPro	IPR020819	DNA repair nuclease, XPF-type/Helicase
InterPro	IPR006166	ERCC4 domain
InterPro	IPR011335	Restriction endonuclease type II--like
Protein Ontology	PR:000010779	crossover junction endonuclease MUS81

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188824 Boon RA, et al., MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res. 2011 Oct 28;109(10):1115-9
All references(42)

Other accession IDs

MGI:2147484, MGI:2147686