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Mus81
Gene Detail
Symbol

Name
ID
Mus81
MUS81 endonuclease homolog (yeast)
MGI:1918961
Synonyms
1200008A18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:5482345-5488402 bp, - strand
From VEGA annotation of GRCm38

  6058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MUS81
Gene Tree: Mus81

Human
homologs
MUS81, MUS81 structure-specific endonuclease subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 80198
neXtProt AC: NX_Q96NY9

Human Synonyms: SLX3

Human Chr (Location): 11q13; chr11:65860244-65866443 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(11) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous null mice for one allele display increased tumor incidence and reduced life spans. Homozygous null mice for a second allele display normal life span and tumor incidence.
 
Human Diseases Modeled in Mice Using Mus81 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Mus81 interacts with 117 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular response to DNA damage stimulus, DNA catabolic process, endonucleolytic, ...
Component nucleolus, nucleus
Function 3'-flap endonuclease activity, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mus81    NEW 
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033940 (Evidence)
Ensembl Gene Model ENSMUSG00000024906 (Evidence)
Entrez Gene 71711 (Evidence)
UniGene 27697
DFCI TC1625148, TC1580842, TC1711136, TC1631122
DoTS DT.99846022, DT.101390217, DT.94131708, DT.99846020, DT.94131704, DT.101390219, DT.94131700, DT.110864611, DT.91374016
NIA Mouse Gene Index U019047
EC 3.1.22.-
PDB 2KP7
Consensus CDS Project CCDS29467.1
International Mouse Phenotyping Consortium Status Mus81
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033940 VEGA Gene Model | MGI Sequence Detail 6058 C57BL/6J ±  kb
transcript OTTMUST00000085631 VEGA | MGI Sequence Detail 2067 Not Applicable 
polypeptide OTTMUSP00000046281 VEGA | MGI Sequence Detail 551 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010996 DNA polymerase beta-like, N-terminal domain
InterPro IPR027420 DNA polymerase beta, N-terminal domain
InterPro IPR020819 DNA repair nuclease, XPF-type/Helicase
InterPro IPR006166 ERCC4 domain
InterPro IPR011335 Restriction endonuclease type II-like
Protein Ontology PR:000010779 crossover junction endonuclease MUS81
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218118 Larin M, et al., Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair. Nucleic Acids Res. 2014 Sep;42(15):9807-20
All references(44)
Disease annotation references (1)
Other
accession IDs
MGI:2147484, MGI:2147686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory