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Mus81 Gene Detail
Summary
  • Symbol
    Mus81
  • Name
    MUS81 structure-specific endonuclease subunit
  • Synonyms
    1200008A18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918961
    NCBI Gene: 71711
  • Gene Overview
    MyGene.info: MUS81
Location & Maps
more
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MUS81, MUS81 structure-specific endonuclease subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MUS81, MUS81 structure-specific endonuclease subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SLX3
  • Links
    NCBI Gene ID: 80198
    neXtProt AC: NX_Q96NY9

  • Chr Location
    11q13; chr11:65860244-65866443 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5725
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MUS81
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Mus81 mouse models

Human Disease Mouse Models
       Arterial Tortuosity Syndrome; ATS   OMIM: 208050 View 1 model
Emphysema, Hereditary Pulmonary   OMIM: 130700 View 1 model
Marfan Syndrome; MFS   OMIM: 154700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 3 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Gene trapped
    11
  • Targeted
    7
  • Incidental Mutations
Homozygous and heterozygous null mice for one allele display increased tumor incidence and reduced life spans. Homozygous null mice for a second allele display normal life span and tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033940 VEGA Gene Model | MGI Sequence Detail 6058 C57BL/6J ±  kb
transcript OTTMUST00000085631 VEGA | MGI Sequence Detail 2067 Not Applicable  
polypeptide OTTMUSP00000046281 VEGA | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010779 crossover junction endonuclease MUS81
  • PDB
  • EC
  • InterPro Domains
    IPR033309 Crossover junction endonuclease Mus81
    IPR010996 DNA polymerase beta-like, N-terminal domain
    IPR027420 DNA polymerase beta, N-terminal domain
    IPR020819 DNA repair nuclease, XPF-type/Helicase
    IPR006166 ERCC4 domain
    IPR011335 Restriction endonuclease type II-like
Molecular
Reagents
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  • All nucleic 41
    cDNA 41

    Microarray probesets 4
Other
Accession IDs
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MGI:2147484, MGI:2147686
References
more
  • Summaries
    All 44
    Diseases 2
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:221273 El Ghamrasni S, et al., Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression. Oncogene. 2015 Apr 2;34(14):1780-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory