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Mus81 Gene Detail
Summary
  • Symbol
    Mus81
  • Name
    MUS81 structure-specific endonuclease subunit
  • Synonyms
    1200008A18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918961
    NCBI Gene: 71711
  • Gene Overview
    MyGene.info: MUS81
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5482836-5488410 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918961
protein coding gene Chr19:5482345-5488410 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024711
protein coding gene Chr19:2451513-2457570 (-)
A/J MGP_AJ_G0024677
protein coding gene Chr19:2317046-2323103 (-)
AKR/J MGP_AKRJ_G0024650
protein coding gene Chr19:2374840-2380897 (-)
BALB/cJ MGP_BALBcJ_G0024677
protein coding gene Chr19:2310710-2316767 (-)
C3H/HeJ MGP_C3HHeJ_G0024445
protein coding gene Chr19:2385114-2391171 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025124
protein coding gene Chr19:2509685-2515742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022554
protein coding gene Chr19:2220210-2226341 (-)
CAST/EiJ MGP_CASTEiJ_G0023917
protein coding gene Chr19:2416529-2422515 (-)
CBA/J MGP_CBAJ_G0024417
protein coding gene Chr19:2620958-2627015 (-)
DBA/2J MGP_DBA2J_G0024544
protein coding gene Chr19:2296895-2302952 (-)
FVB/NJ MGP_FVBNJ_G0024511
protein coding gene Chr19:2303106-2309497 (-)
LP/J MGP_LPJ_G0024630
protein coding gene Chr19:2431028-2439069 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024541
protein coding gene Chr19:2471163-2478796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025172
protein coding gene Chr19:2399624-2405681 (-)
PWK/PhJ MGP_PWKPhJ_G0023663
protein coding gene Chr19:2333734-2339798 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023468
protein coding gene Chr19:2378476-2384539 (-)
WSB/EiJ MGP_WSBEiJ_G0023979
protein coding gene Chr19:2406472-2413268 (-)



Homology
more
  • Human Ortholog
    MUS81, MUS81 structure-specific endonuclease subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MUS81, MUS81 structure-specific endonuclease subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLX3
  • Links
    NCBI Gene ID: 80198
    neXtProt AC: NX_Q96NY9
    UniProt: Q96NY9

  • Chr Location
    11q13.1; chr11:65860244-65866443 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5725
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MUS81
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Mus81 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 3 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous and heterozygous null mice for one allele display increased tumor incidence and reduced life spans. Homozygous null mice for a second allele display normal life span and tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71711 NCBI Gene Model | MGI Sequence Detail 5575 C57BL/6J ±  kb
transcript NR_153768 RefSeq | MGI Sequence Detail 2345 C57BL/6  
polypeptide Q91ZJ0 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147484, MGI:2147686
References
more
  • Summaries
    All 52
    Diseases 2
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232402 Thongthip S, et al., Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction. Genes Dev. 2016 Mar 15;30(6):645-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory