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Mus81
Gene Detail
 Symbol
Name
ID
Mus81
MUS81 endonuclease homolog (yeast)
MGI:1918961
Synonyms 1200008A18Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:5482345-5488402 bp, - strand
From VEGA annotation of GRCm38

  6058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Mus81

Human
homologs
Human Homolog MUS81, MUS81 structure-specific endonuclease subunit
NCBI Gene ID 80198
neXtProt AC  NX_Q96NY9
Human Synonyms  SLX3
Human Chr (Location)  11q13; chr11:65860401-65866443 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(11) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous null mice for one allele display increased tumor incidence and reduced life spans. Homozygous null mice for a second allele display normal life span and tumor incidence.
 
Human Diseases Modeled Using Mouse Mus81 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Mus81 interacts with 117 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular response to DNA damage stimulus, DNA catabolic process, endonucleolytic, ...
Component intercellular bridge, nucleus
Function 3'-flap endonuclease activity, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033940 (Evidence)
Ensembl Gene ModelENSMUSG00000024906 (Evidence)
Entrez Gene71711 (Evidence)
UniGene27697
DFCITC1580842, TC1625148, TC1631122, TC1711136
DoTSDT.101390217, DT.101390219, DT.110864611, DT.91374016, DT.94131700, DT.94131704, DT.94131708, DT.99846020, DT.99846022
NIA Mouse Gene IndexU019047
EC3.1.22.-
PDB2KP7
Consensus CDS ProjectCCDS29467.1
International Mouse Knockout Project StatusMus81
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033940 VEGA Gene Model | MGI Sequence Detail 6058 C57BL/6J ±  kb
transcript OTTMUST00000085631 VEGA | MGI Sequence Detail 2067 Not Applicable 
polypeptide OTTMUSP00000046281 VEGA | MGI Sequence Detail 551 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010996 DNA polymerase beta-like, N-terminal domain
InterPro IPR027420 DNA polymerase beta, N-terminal domain
InterPro IPR020819 DNA repair nuclease, XPF-type/Helicase
InterPro IPR006166 ERCC4 domain
InterPro IPR011335 Restriction endonuclease type II-like
Protein Ontology PR:000010779 crossover junction endonuclease MUS81
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204996 Castor D, et al., Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell. 2013 Oct 24;52(2):221-33
All references(44)
Disease annotation references (1)
Other
accession IDs
MGI:2147484, MGI:2147686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory