Ifih1
Gene Detail

Symbol Name ID

Ifih1 interferon induced with helicase C domain 1 MGI:1918836

Synonyms

9130009C22Rik, Helicard, MDA5, MDA-5

Feature Type

protein coding gene

Genetic Map

Chromosome 2

35.85 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:62595798-62646255 bp, - strand From VEGA annotation of GRCm38   50458 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interferon-induced helicase C domain-containing protein 1
Gene Tree: Ifih1

Human homologs

Human Homolog		IFIH1, interferon induced with helicase C domain 1
NCBI Gene ID		64135
neXtProt AC		NX_Q9BYX4
Human Synonyms		Hlcd, IDDM19, MDA5, MDA-5, RLR-2
Human Chr (Location)		2q24; chr2:163123589-163175218 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele have increased virus-associated morbidity and mortality, and decreased cytokine response to several viral infection.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	defense response to virus, innate immune response, ...
Component	cytoplasm, intracellular, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

cDNA source data(52)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(52)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000012871 (Evidence)
Ensembl Gene Model	ENSMUSG00000026896 (Evidence)
Entrez Gene	71586 (Evidence)
UniGene	136224
DFCI	TC1579199, TC1594932, TC1604412, TC1626801
DoTS	DT.101196895, DT.103561066, DT.491550, DT.99851790
NIA Mouse Gene Index	U022677, U022678
EC	3.6.4.13
PDB	3TS9
Consensus CDS Project	CCDS16068.1, CCDS50594.1
International Mouse Knockout Project Status	Ifih1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012871	VEGA Gene Model | MGI Sequence Detail	50458	C57BL/6J
transcript	OTTMUST00000030862	VEGA | MGI Sequence Detail	5470	Not Applicable
polypeptide	OTTMUSP00000013829	VEGA | MGI Sequence Detail	1025	Not Applicable

All sequences(60) RefSeq(4) UniProt(7)

Polymorphisms

SNPs within 2kb(591 from dbSNP Build 137)    SNPs within 2kb including multiple locations(593)

Protein-related information

Resource	ID	Description
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR021673	C-terminal domain of RIG-I
InterPro	IPR011029	Death-like domain
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR006935	Helicase/UvrB domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000008910	interferon-induced helicase C domain-containing protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197207 Ermler ME, et al., RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge. J Virol. 2013 May;87(9):4846-60
All references(74)