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Ifih1
Gene Detail
 Symbol
Name
ID
Ifih1
interferon induced with helicase C domain 1
MGI:1918836
Synonyms 9130009C22Rik, Helicard, MDA5, MDA-5
Feature Type protein coding gene
Genetic Map
Chromosome 2
35.85 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:62595798-62646255 bp, - strand
From VEGA annotation of GRCm38

  50458 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon-induced helicase C domain-containing protein 1
Gene Tree: Ifih1

Human
homologs
Human Homolog IFIH1, interferon induced with helicase C domain 1
NCBI Gene ID 64135
neXtProt AC  NX_Q9BYX4
Human Synonyms  AGS7, Hlcd, IDDM19, MDA5, MDA-5, RLR-2
Human Chr (Location)  2q24; chr2:162267079-162318708 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IFIH1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have increased virus-associated morbidity and mortality, and decreased cytokine response to several viral infection.
 
Interactions
Ifih1 interacts with 313 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process defense response to virus, immune system process, ...
Component cytoplasm, nucleus
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(52)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(52)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012871 (Evidence)
Ensembl Gene ModelENSMUSG00000026896 (Evidence)
Entrez Gene71586 (Evidence)
UniGene136224
DFCITC1579199, TC1594932, TC1604412, TC1626801
DoTSDT.101196895, DT.103561066, DT.491550, DT.99851790
NIA Mouse Gene IndexU022677, U022678
EC3.6.4.13
PDB3TS9
Consensus CDS ProjectCCDS16068.1, CCDS50594.1
International Mouse Knockout Project StatusIfih1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012871 VEGA Gene Model | MGI Sequence Detail 50458 C57BL/6J ±  kb
transcript OTTMUST00000030862 VEGA | MGI Sequence Detail 5470 Not Applicable 
polypeptide OTTMUSP00000013829 VEGA | MGI Sequence Detail 1025 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(591 from dbSNP Build 137)    SNPs within 2kb including multiple locations(593)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR021673 C-terminal domain of RIG-I
InterPro IPR011029 Death-like domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR006935 Helicase/UvrB domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008910 interferon-induced helicase C domain-containing protein 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209086 Chiang HS, et al., GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol. 2014 Jan;15(1):63-71
All references(78)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory