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Ifih1 Gene Detail
Summary
  • Symbol
    Ifih1
  • Name
    interferon induced with helicase C domain 1
  • Synonyms
    9130009C22Rik, Helicard, MDA5, MDA-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918836
    NCBI Gene: 71586
  • Gene Overview
    MyGene.info: IFIH1
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:62595798-62646255 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 35.85 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    586 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918836
 protein coding gene Chr2:62595793-62646255 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025772
 protein coding gene Chr2:62293695-62346841 (-)
A/J MGP_AJ_G0025748
 protein coding gene Chr2:59905419-59955850 (-)
AKR/J MGP_AKRJ_G0025718
 protein coding gene Chr2:61506532-61558526 (-)
BALB/cJ MGP_BALBcJ_G0025743
 protein coding gene Chr2:60018652-60070207 (-)
C3H/HeJ MGP_C3HHeJ_G0025504
 protein coding gene Chr2:61616408-61666615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026190
 protein coding gene Chr2:64110273-64164912 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023594
 protein coding gene Chr2:57420631-57470418 (-)
CAST/EiJ MGP_CASTEiJ_G0024968
 protein coding gene Chr2:61690882-61744958 (-)
CBA/J MGP_CBAJ_G0025484
 protein coding gene Chr2:66554719-66609818 (-)
DBA/2J MGP_DBA2J_G0025615
 protein coding gene Chr2:59484041-59535625 (-)
FVB/NJ MGP_FVBNJ_G0025577
 protein coding gene Chr2:59008196-59056484 (-)
LP/J MGP_LPJ_G0025703
 protein coding gene Chr2:62115703-62170405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025608
 protein coding gene Chr2:68246576-68303389 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026247
 protein coding gene Chr2:61580603-61630969 (-)
PWK/PhJ MGP_PWKPhJ_G0024709
 protein coding gene Chr2:59351086-59402726 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024516
 protein coding gene Chr2:61725516-61777603 (-)
WSB/EiJ MGP_WSBEiJ_G0025036
 protein coding gene Chr2:61903342-61955376 (-)



Homology
more
  • Human Ortholog
    IFIH1, interferon induced with helicase C domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFIH1, interferon induced with helicase C domain 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGS7, Hlcd, IDDM19, MDA5, MDA-5, RLR-2, SGMRT1
  • Links
    NCBI Gene ID: 64135
    neXtProt AC: NX_Q9BYX4
    UniProt: Q9BYX4

  • Chr Location
    2q24.2; chr2:162267079-162318708 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Ifih1 mouse models; 1 with human IFIH1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have increased virus-associated morbidity and mortality, and decreased cytokine response to several viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    53
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026896 Ensembl Gene Model | MGI Sequence Detail 50458 C57BL/6J ±  kb
transcript ENSMUST00000028259 Ensembl | MGI Sequence Detail 5470 Not Applicable  
polypeptide ENSMUSP00000028259 Ensembl | MGI Sequence Detail 1025 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 4
References
more
  • Summaries
    All 107
    Diseases 1
    Gene Ontology 6
    Phenotypes 57
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:262477 Karki R, et al., IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018 May 3;173(4):920-933.e13
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/27/2018
MGI 6.13 		The Jackson Laboratory