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Pdss2 Gene Detail
Summary
  • Symbol
    Pdss2
  • Name
    prenyl (solanesyl) diphosphate synthase, subunit 2
  • Synonyms
    5430420P03Rik, kd, mDLP1, PLMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918615
    NCBI Gene: 71365
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:43097482-43340878 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.91 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1012 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918615
protein coding gene Chr10:43095396-43340878 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017192
protein coding gene Chr10:41977238-42236280 (+)
A/J MGP_AJ_G0017169
protein coding gene Chr10:40799941-41058223 (+)
AKR/J MGP_AKRJ_G0017129
protein coding gene Chr10:41412860-41663302 (+)
BALB/cJ MGP_BALBcJ_G0017131
protein coding gene Chr10:40852040-41095796 (+)
C3H/HeJ MGP_C3HHeJ_G0016952
protein coding gene Chr10:41779141-42036226 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017590
protein coding gene Chr10:43252490-43517987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015286
protein coding gene Chr10:38641673-38879830 (+)
CAST/EiJ MGP_CASTEiJ_G0016531
protein coding gene Chr10:41993949-42258001 (+)
CBA/J MGP_CBAJ_G0016926
protein coding gene Chr10:45243689-45510327 (+)
DBA/2J MGP_DBA2J_G0017031
protein coding gene Chr10:40277289-40519937 (+)
FVB/NJ MGP_FVBNJ_G0017026
protein coding gene Chr10:39772023-40014210 (+)
LP/J MGP_LPJ_G0017108
protein coding gene Chr10:41986682-42243605 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017056
protein coding gene Chr10:45968438-46229486 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017627
protein coding gene Chr10:41424164-41691612 (+)
PWK/PhJ MGP_PWKPhJ_G0016311
protein coding gene Chr10:40162837-40406183 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016095
protein coding gene Chr10:41254097-41528930 (+)
WSB/EiJ MGP_WSBEiJ_G0016594
protein coding gene Chr10:41715186-41966303 (+)



Homology
more
  • Human Ortholog
    PDSS2, decaprenyl diphosphate synthase subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDSS2, decaprenyl diphosphate synthase subunit 2
  • Synonyms
    bA59I9.3, C6orf210, COQ10D3, COQ1B, DLP1, hDLP1
  • Links
    NCBI Gene ID: 57107
    neXtProt AC: NX_Q86YH6
    UniProt: Q86YH6

  • Chr Location
    6q21; chr6:107152562-107459564 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Pdss2 mouse models; 1 with human PDSS2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 6 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in renal abnormalities leading to early death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038240 Ensembl Gene Model | MGI Sequence Detail 243397 C57BL/6J ±  kb
    transcript ENSMUST00000095725 Ensembl | MGI Sequence Detail 2127 Not Applicable  
    polypeptide ENSMUSP00000093393 Ensembl | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11583, MGI:96674
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:5232 Lyon MF, et al., An inherited kidney disease of mice resembling human nephronophthisis. J Med Genet. 1971 Mar;8(1):41-8
    • Latest
      J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory