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Pdss2 Gene Detail
Summary
  • Symbol
    Pdss2
  • Name
    prenyl (solanesyl) diphosphate synthase, subunit 2
  • Synonyms
    5430420P03Rik, kd, mDLP1, PLMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918615
    NCBI Gene: 71365
  • Gene Overview
    MyGene.info: PDSS2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:43221486-43464882 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.91 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1013 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918615
protein coding gene Chr10:43221156-43464882 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017192
protein coding gene Chr10:41977238-42236280 (+)
A/J MGP_AJ_G0017169
protein coding gene Chr10:40799941-41058223 (+)
AKR/J MGP_AKRJ_G0017129
protein coding gene Chr10:41412860-41663302 (+)
BALB/cJ MGP_BALBcJ_G0017131
protein coding gene Chr10:40852040-41095796 (+)
C3H/HeJ MGP_C3HHeJ_G0016952
protein coding gene Chr10:41779141-42036226 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017590
protein coding gene Chr10:43252490-43517987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015286
protein coding gene Chr10:38641673-38879830 (+)
CAST/EiJ MGP_CASTEiJ_G0016531
protein coding gene Chr10:41993949-42258001 (+)
CBA/J MGP_CBAJ_G0016926
protein coding gene Chr10:45243689-45510327 (+)
DBA/2J MGP_DBA2J_G0017031
protein coding gene Chr10:40277289-40519937 (+)
FVB/NJ MGP_FVBNJ_G0017026
protein coding gene Chr10:39772023-40014210 (+)
LP/J MGP_LPJ_G0017108
protein coding gene Chr10:41986682-42243605 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017056
protein coding gene Chr10:45968438-46229486 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017627
protein coding gene Chr10:41424164-41691612 (+)
PWK/PhJ MGP_PWKPhJ_G0016311
protein coding gene Chr10:40162837-40406183 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016095
protein coding gene Chr10:41254097-41528930 (+)
WSB/EiJ MGP_WSBEiJ_G0016594
protein coding gene Chr10:41715186-41966303 (+)



Homology
more
  • Human Ortholog
    PDSS2, decaprenyl diphosphate synthase subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDSS2, decaprenyl diphosphate synthase subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA59I9.3, C6orf210, COQ10D3, DLP1, hDLP1
  • Links
    NCBI Gene ID: 57107
    neXtProt AC: NX_Q86YH6
    UniProt: Q86YH6

  • Chr Location
    6q21; chr6:107152557-107459683 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56885
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PDSS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Pdss2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 6 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in renal abnormalities leading to early death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038240 Ensembl Gene Model | MGI Sequence Detail 243397 C57BL/6J ±  kb
transcript ENSMUST00000095725 Ensembl | MGI Sequence Detail 2127 Not Applicable  
polypeptide ENSMUSP00000093393 Ensembl | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11583, MGI:96674
References
more
  • Summaries
    All 56
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:5232 Lyon MF, et al., An inherited kidney disease of mice resembling human nephronophthisis. J Med Genet. 1971 Mar;8(1):41-8
  • Latest
    J:227578 Ben-Meir A, et al., Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory