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Pdss2 Gene Detail
Summary
  • Symbol
    Pdss2
  • Name
    prenyl (solanesyl) diphosphate synthase, subunit 2
  • Synonyms
    5430420P03Rik, kd, mDLP1, PLMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918615
    NCBI Gene: 71365
  • Gene Overview
    MyGene.info: PDSS2
Location & Maps
more
  • Sequence Map
    Chr10:43221486-43464882 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      243397 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.91 cM, cytoband B2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PDSS2, prenyl (decaprenyl) diphosphate synthase, subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDSS2, prenyl (decaprenyl) diphosphate synthase, subunit 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA59I9.3, C6orf210, COQ10D3, DLP1, hDLP1
  • Links
    NCBI Gene ID: 57107
    neXtProt AC: NX_Q86YH6

  • Chr Location
    6q21; chr6:107152557-107459702 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56885
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PDSS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Pdss2 mouse models; 1 with human PDSS2 associations

Human Disease Mouse Models
       Coenzyme Q10 Deficiency, Primary, 1; COQ10D1   OMIM: 607426 View 1 model
       Coenzyme Q10 Deficiency, Primary, 3; COQ10D3   OMIM: 614652
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 6 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    8
  • Genomic Mutations
    2 involving Pdss2
  • Incidental Mutations
Mutations in this gene result in renal abnormalities leading to early death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034999 VEGA Gene Model | MGI Sequence Detail 243397 C57BL/6J ±  kb
transcript OTTMUST00000089000 VEGA | MGI Sequence Detail 2127 Not Applicable  
polypeptide OTTMUSP00000048577 VEGA | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1013 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11583, MGI:96674
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:24778 Hulse EV, et al., Kidney disease, kd. Mouse News Lett. 1965;32:38
  • Latest
    J:227578 Ben-Meir A, et al., Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory