Pdss2
Gene Detail

Symbol Name ID

Pdss2 prenyl (solanesyl) diphosphate synthase, subunit 2 MGI:1918615

Synonyms

5430420P03Rik, kd, mDLP1, PLMP

Feature Type

protein coding gene

Genetic Map

Chromosome 10

22.91 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:43221486-43464882 bp, + strand From VEGA annotation of GRCm38   243397 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pdss2

Human homologs

Human Homolog		PDSS2, prenyl (decaprenyl) diphosphate synthase, subunit 2
NCBI Gene ID		57107
neXtProt AC		NX_Q86YH6
Human Synonyms		bA59I9.3, C6orf210, COQ10D3, DLP1, hDLP1
Human Chr (Location)		6q21; chr6:107473761-107780779 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PDSS2

Alleles and phenotypes

All alleles(15) : Targeted(7) Gene trapped(7) Spontaneous(1)
 

Mutations in this gene result in renal abnormalities leading to early death.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	isoprenoid biosynthetic process, protein heterotetramerization, ...
Component	cytoplasm, mitochondrion
Function	protein heterodimerization activity, transferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(24)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034999 (Evidence)
Ensembl Gene Model	ENSMUSG00000038240 (Evidence)
Entrez Gene	71365 (Evidence)
UniGene	363225
DFCI	TC1588175, TC1662629
DoTS	DT.110631740, DT.40149411, DT.525373, DT.91437068, DT.97390229
NIA Mouse Gene Index	U011458
EC	2.5.1.91
Consensus CDS Project	CCDS35891.1, CCDS48552.1
International Mouse Knockout Project Status	Pdss2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034999	VEGA Gene Model | MGI Sequence Detail	243397	C57BL/6J
transcript	OTTMUST00000089000	VEGA | MGI Sequence Detail	2127	Not Applicable
polypeptide	OTTMUSP00000048577	VEGA | MGI Sequence Detail	401	Not Applicable

All sequences(49) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(831 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000092	Polyprenyl synthetase
InterPro	IPR017446	Polyprenyl synthetase-related
InterPro	IPR008949	Terpenoid synthase
Protein Ontology	PR:000012522	decaprenyl-diphosphate synthase subunit 2

References

(Earliest) J:24778 Hulse EV, et al., Kidney disease, kd. Mouse News Lett. 1965;32:38
(Latest) J:192142 Ziegler CG, et al., Parkinson's disease-like neuromuscular defects occur in prenyl diphosphate synthase subunit 2 (Pdss2) mutant mice. Mitochondrion. 2012 Mar;12(2):248-57
All references(49)

Other accession IDs

MGD-MRK-11583, MGI:96674