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Pdss2
Gene Detail
 Symbol
Name
ID
Pdss2
prenyl (solanesyl) diphosphate synthase, subunit 2
MGI:1918615
Synonyms 5430420P03Rik, kd, mDLP1, PLMP
Feature Type protein coding gene
Genetic Map
Chromosome 10
22.91 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:43221486-43464882 bp, + strand
From VEGA annotation of GRCm38

  243397 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pdss2

Human
homologs
Human Homolog PDSS2, prenyl (decaprenyl) diphosphate synthase, subunit 2
NCBI Gene ID 57107
neXtProt AC  NX_Q86YH6
Human Synonyms  bA59I9.3, C6orf210, COQ10D3, DLP1, hDLP1
Human Chr (Location)  6q21; chr6:107152557-107459575 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDSS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(7) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in renal abnormalities leading to early death.
 
Human Diseases Modeled Using Mouse Pdss2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Pdss2 interacts with 318 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process isoprenoid biosynthetic process, protein heterotetramerization, ...
Component cytoplasm, mitochondrion
Function protein heterodimerization activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034999 (Evidence)
Ensembl Gene ModelENSMUSG00000038240 (Evidence)
Entrez Gene71365 (Evidence)
UniGene490430
DFCITC1588175, TC1662629
DoTSDT.110631740, DT.40149411, DT.525373, DT.91437068, DT.97390229
NIA Mouse Gene IndexU011458
EC2.5.1.91
Consensus CDS ProjectCCDS35891.1, CCDS48552.1
International Mouse Knockout Project StatusPdss2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034999 VEGA Gene Model | MGI Sequence Detail 243397 C57BL/6J ±  kb
transcript OTTMUST00000089000 VEGA | MGI Sequence Detail 2127 Not Applicable 
polypeptide OTTMUSP00000048577 VEGA | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(1017 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000092 Polyprenyl synthetase
InterPro IPR017446 Polyprenyl synthetase-related
InterPro IPR008949 Terpenoid synthase
Protein Ontology PR:000012522 decaprenyl-diphosphate synthase subunit 2
References (Earliest) J:24778 Hulse EV, et al., Kidney disease, kd. Mouse News Lett. 1965;32:38
(Latest) J:197578 Quinzii CM, et al., Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice. FASEB J. 2013 Feb;27(2):612-21
All references(50)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11583, MGI:96674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory