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Aifm2 Gene Detail
Summary
  • Symbol
    Aifm2
  • Name
    apoptosis-inducing factor, mitochondrion-associated 2
  • Synonyms
    5430437E11Rik, Amid, D730001I10Rik, PRG3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918611
    NCBI Gene: 71361
  • Gene Overview
    MyGene.info: AIFM2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61715263-61739260 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918611
protein coding gene Chr10:61715263-61739260 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017287
protein coding gene Chr10:61081620-61108146 (+)
A/J MGP_AJ_G0017265
protein coding gene Chr10:59244520-59268376 (+)
AKR/J MGP_AKRJ_G0017225
protein coding gene Chr10:60788734-60814466 (+)
BALB/cJ MGP_BALBcJ_G0017225
protein coding gene Chr10:59319481-59345052 (+)
C3H/HeJ MGP_C3HHeJ_G0017048
protein coding gene Chr10:60690904-60718481 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017683
protein coding gene Chr10:63262483-63307967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015374
protein coding gene Chr10:56219332-56242151 (+)
CAST/EiJ MGP_CASTEiJ_G0016619
protein coding gene Chr10:60711185-60735742 (+)
CBA/J MGP_CBAJ_G0017020
protein coding gene Chr10:65624749-65650924 (+)
DBA/2J MGP_DBA2J_G0017125
protein coding gene Chr10:58515018-58539303 (+)
FVB/NJ MGP_FVBNJ_G0017119
protein coding gene Chr10:57766406-57791556 (+)
LP/J MGP_LPJ_G0017200
protein coding gene Chr10:61476431-61500328 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017147
protein coding gene Chr10:67925374-67953867 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017721
protein coding gene Chr10:60616157-60641576 (+)
PWK/PhJ MGP_PWKPhJ_G0016402
protein coding gene Chr10:58363168-58391890 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016185
protein coding gene Chr10:59979170-60008501 (+)
WSB/EiJ MGP_WSBEiJ_G0016683
protein coding gene Chr10:60530579-60554393 (+)



Homology
more
  • Human Ortholog
    AIFM2, apoptosis inducing factor, mitochondria associated 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AIFM2, apoptosis inducing factor, mitochondria associated 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMID, PRG3
  • Links
    NCBI Gene ID: 84883
    neXtProt AC: NX_Q9BRQ8
    UniProt: Q9BRQ8

  • Chr Location
    10q22.1; chr10:70112267-70132934 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Aifm2
  • Find Mice (IMSR)
Homozygous null mice display reduced sensitivity to genotoxin induced cellular growth inhibition but have no change in spontaneous or induced tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71361 NCBI Gene Model | MGI Sequence Detail 23998 C57BL/6J ±  kb
transcript NM_001039194 RefSeq | MGI Sequence Detail 3152 C57BL/6  
polypeptide Q8BUE4 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 5
Other
Accession IDs
less
MGI:1926110
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory